A5009970653- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Total Knee Arthroplasty Outcomes
- Spondyloarthritis Studies and Treatments
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Respiratory Support and Mechanisms
- Shoulder Injury and Treatment
- Synthesis and properties of polymers
- Knee injuries and reconstruction techniques
- RNA and protein synthesis mechanisms
- Psoriasis: Treatment and Pathogenesis
- Biomarkers in Disease Mechanisms
- Cellular Mechanics and Interactions
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- Bone Metabolism and Diseases
- Antimicrobial Peptides and Activities
Renji Hospital
2006-2025
Shanghai Jiao Tong University
2016-2025
Jiangmen Central Hospital
2023
Background: Sepsis has a high mortality rate. While early diagnosis is crucial, there are no effective inflammatory or infectious markers for the and prediction of sepsis. Objective: The present study aimed to establish correlation between severity sepsis at genetic cross-sectional level. Methods: Using transcriptomic clinical data from GEO Dryad databases, we analyzed expression eight indicators infection, as well their diagnostic efficacy. Additionally, investigated plasma biomarkers...
The data in electronic medical records (EMR) are complex structure. They independent, yet related to each other. In order improve information access through the use of EMR, annotating work on these is necessary. annotation metadata, resource which contain a meta-model database, basis if semi-automated or an automated approach aims at making database more accessible expected. this study, method has been proposed transform terms cannot be matched directly by changing them literally but...
Abstract Background Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs CD4 + T cells from patients with systemic lupus erythematosus (SLE) and their potential function the SLE pathogenesis. Methods First, small RNA sequencing was performed on four three healthy controls (HCs). Candidate were then validated 97 relevant disease using qRT-PCR. Then used investigate profiles HC-derived...
Fibrocartilaginous regeneration at the tendon-to-bone interface is a major challenge for rotator cuff tear repair. We fabricated decellularized umbilical cord Wharton's jelly (DUCWJ) scaffold by decellularization method and performed histological proteomic analyses. then synthesized kartogenin-conjugated DUCWJ (DUCWJ-KGN) using an EDC/NHS catalyst. 1H NMR, Fluorescence staining, FTIR confirmed that carboxyl group of KGN was covalently coupled with free amine groups in (WJ) matrix, vitro...
The concept that inflammation serves a leading role in osteoclast‑induced bone loss under pathological circumstances is now widely accepted. In the present study, it was observed lipopolysaccharides (LPSs) demonstrated synergic effect on receptor activator of nuclear factor κ‑B ligand (RANKL)‑induced osteoclast differentiation Raw264.7 cells, with increasing levels multiple pro‑inflammatory cytokines including interleukin (IL)‑6, tumor necrosis factor‑α and IL‑1β. Furthermore, microRNA...
To assess the diagnostic delay (DD) and physician-related DD (pDD) in patients with axial spondyloarthritis (SpA) potential benefits of a multidisciplinary clinic (MDC) approach.A retrospective study was undertaken among SpA, which aimed to analyse DD, pDD their risk factors. The influence on disease outcomes examined. pDDs consecutive SpA an MDC cohort were compared propensity score matched historical controls (1:1).A total 208 formed control group 49 after introduction MDC. median 25.5...
Abstract Background The posterior cruciate ligament (PCL) attachment may be damaged in cruciate-retaining total knee arthroplasty (CR-TKA) using the complete resection for tibial preparation, and amount varies greatly among individuals. Discoid lateral meniscus (DLM) is one of most common anatomic variants. This study aimed to evaluate difference PCL sacrifice CR-TKA between patients with without DLM. Methods Fifty-one knees group (DLM group) were matched 1:1 51 control (non-DLM by age, sex,...
Objective To set up a mouse model of spondyloarthritis, analyzethe clinical phenotype, radiographic and pathological features, investigate the therapeutic effect cysteine-rich 61 (CCN1) monoclonal antibody in spondyloarthritis model. Methods Proteoglycan from bovine nasal septum was used for immunization 14-16 week old female BALB/c mice. CCN1 093G9 or control immunoglobulin (Ig)G were injected to The arthritis scores analyzed by t test. Peripheral axial joints disease development...
Objective To investigate the prevalence of uveitis associated with axial spondyloarthritis (ax-SpA), and analyze features patients ax-SpA accompanying uveitis. Methods Two hundred eighteen were recruited. The differences in demographic factors, clinical features, use drugs quality life compared between group non-uveitis by using t-tests χ2 tests. Results The was 24.3%. Uveitis had longer disease duration [(156±140) month] to [(84±98) (t=-3.473, P=0.001), from onset diagnosis...
Abstract Objective and design We aimed to explore the correlation between eight plasma biomarkers Sequential Organ Failure Assessment (SOFA) score in sepsis. Subjects Adult medical non-trauma patients with sepsis (n = 450) were enrolled University of Pittsburgh Acute Lung Injury Registry (ALIR) October 2011 January 2018. The final cohort consisted 153 (SOFA > 2). Methods PTX-3 was analyzed using multiple statistical tests along SOFA scores remaining ALIR data. Threshold effect analysis...
Abstract Background Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs CD4 + T cells from patients with systemic lupus erythematosus (SLE) and their potential function SLE pathogenesis. Methods First, small RNA sequencing was performed on four three healthy controls (HCs). Candidate were then validated 97 relevant disease using qRT-PCR. Then used investigate the profiles HC-derived...