A5035839603- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- SARS-CoV-2 and COVID-19 Research
- Kruppel-like factors research
- Influenza Virus Research Studies
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
Eindhoven University of Technology
2022
Abstract 3D‐scaffold based in vitro human tissue models accelerate disease studies and screening of pharmaceutics while improving the clinical translation findings. Here is reported use induced pluripotent stem cell (hiPSC)‐derived vascular organoid cells as a new source for creation an electrospun polycaprolactone‐bisurea (PCL‐BU) 3D‐scaffold‐based, perfused macrovessel model. A separation protocol developed to obtain monocultures organoid‐derived endothelial (ODECs) mural (ODMCs) from...
Abstract Background Mucosal antibodies play a critical role in preventing SARS-CoV-2 infections or reinfections by blocking the interaction of receptor-binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor on cell surface. In this study, we investigated difference between mucosal antibody response after primary infection and vaccination. Methods We assessed longitudinal changes quantity capacity nasal to neutralize RBD ACE2 using spike protein from ancestral (Wuhan-Hu-1),...
Increasing evidence suggests that natural killer (NK) cells are composed of distinct functional subsets. This multifunctional role has made them an attractive choice for anticancer immunotherapy. A NK cell repertoire is generated through cellular education, resulting in a heterogeneous population with capabilities responding to different stimuli. The application high-throughput droplet-based microfluidic platform allows monitoring cell-target interactions at the single-cell level and...
Abstract Increasing evidence suggest that Natural killer (NK) cells are composed of distinct functional subsets. This multi-functional role displayed by NK have made them an attractive choice for anti-cancer immunotherapy. A cell repertoire is generated through cellular education, resulting in heterogeneous population with capabilities to respond different stimuli. The application a high-throughput droplet-based microfluidic platform allows monitoring cell-target interactions at single-cell...