A5011573701- Heavy Metal Exposure and Toxicity
- Cannabis and Cannabinoid Research
- Arsenic contamination and mitigation
- Trace Elements in Health
- Poisoning and overdose treatments
- Mercury impact and mitigation studies
- Heavy metals in environment
- Air Quality and Health Impacts
- Smoking Behavior and Cessation
- Healthcare and Environmental Waste Management
- Substance Abuse Treatment and Outcomes
- Molecular Sensors and Ion Detection
- Forensic Toxicology and Drug Analysis
- Acne and Rosacea Treatments and Effects
- Environmental Justice and Health Disparities
- Fluoride Effects and Removal
- Hematological disorders and diagnostics
- Immunotoxicology and immune responses
- Lanthanide and Transition Metal Complexes
- Advanced Glycation End Products research
- Pesticide Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Retinoids in leukemia and cellular processes
- Aluminum toxicity and tolerance in plants and animals
Colorado School of Public Health
2021-2024
University of Colorado Anschutz Medical Campus
2006-2024
Indiana University School of Medicine
2023
University of Colorado Denver
2010-2022
Collaborative Research Group
2022
Rajarata University of Sri Lanka
2022
American College of Medical Toxicology
2022
The University of Texas Southwestern Medical Center
2022
Fort Valley State University
2022
Washington Poison Center
2012
It has been suggested that the indigenous Atacameño people in Northern Chile might be protected from health effects of arsenic drinking water because many centuries exposure. Here we report on first intensive investigation arsenic-induced skin lesions this population. We selected 11 families (44 participants) village Chiu Chiu, which is supplied with containing between 750 and 800 microg/L inorganic arsenic. For comparison, 8 (31 were also a where contains approximately 10 After being...
Ingestion of arsenic, both from water supplies and medicinal preparations, is known to cause skin cancer. The evidence assessed here indicates that arsenic can also liver, lung, kidney, bladder cancer the population risks due in U.S. may be comparable those environmental tobacco smoke radon homes. Large studies an area Taiwan with high levels well (170-800 micrograms/L) were used establish dose-response relationships between concentration inorganic naturally present supplies. It was...
We investigated the evidence of a familial contribution to urinary methylation patterns in families ingesting arsenic drinking water. Arsenic can be assessed by measuring levels inorganic (InAs) and its methylated metabolites, monomethylarsonate (MMA), dimethylarsinate (DMA). Methylation activity is reflected ratios: InAs/methylated (InAs/metAs) MMA/DMA. Eleven from Chile were selected because their long-term exposure very high water (735-762 microg/L). Each family consisted father, mother,...
To determine the influence of demographic, exposure and medical factors on bone lead concentration subjects with background (nonindustrial) environmental exposure.Survey.Suburban residential community.A total 101 (49 males, 52 females; aged 11 to 78 years) were recruited from 49 123 households geographically located in a suburban neighborhood unexposed any major source industrial emissions.Cortical concentrations midshaft tibia noninvasively measured by vivo K x-ray fluorescence. Blood...
Despite clinical experience that spans more than half a century, chelation for toxic heavy metals represents one of the most controversial and misapplied interventions in toxicology. The prompt use chelating agents to treat acute, life-threatening intoxication is an indication largely supported by experimental animal data limited research. Although administered chronic may accelerate excretion metals, their therapeutic efficacy terms decreased morbidity mortality unestablished. Recent...
Background In 2010, Médecins Sans Frontières (MSF) discovered extensive lead poisoning impacting several thousand children in rural northern Nigeria. An estimated 400 fatalities had occurred over 3 mo. The US Centers for Disease Control and Prevention (CDC) confirmed widespread contamination from lead-rich ore being processed gold, environmental management was begun. MSF commenced a medical programme that included treatment with the oral chelating agent 2,3-dimercaptosuccinic acid (DMSA,...
In 2013, an occupational medicine physician from the University of California, San Francisco, contacted CDC's National Institute for Occupational Safety and Health (NIOSH), Administration (OSHA) about two oil gas extraction worker deaths in western United States. The suspected cause these was exposure to hydrocarbon gases vapors (HGVs) oxygen (O2)-deficient atmospheres after opening hatches storage tanks. experts NIOSH OSHA reviewed available fatality reports January 2010 March 2015,...
Background Lead stabilizers (e.g., lead sulfate, stearate) are common additives in plastics used electrical devices. In 1997, three compounders at one California company were severely lead-poisoned. Methods The poisonings investigated by interviewing the workers, employer, and treating physician reviewing medical records environmental monitoring results. addition to measuring blood levels (BLLs), noninvasive K X-ray fluorescence was measure bone concentration of index case. Results Blood...
Research findings have heightened public health concern regarding the hazards of low dose lead exposure to adults and children.In adults, studies established potential for hypertension, decrements in renal function, subtle decline cognitive adverse reproductive outcome at blood levels less than 25 micrograms per deciliter (µg/dL).The developing nervous system fetus young child is particularly sensitive deleterious effects lead, with impacts on physical growth neurocognitive development...
Abstract Background Acute cannabis use has been demonstrated to slow reaction time and affect decision-making short-term memory. These effects may have utility in identifying impairment associated with recent use. However, these not widely investigated among individuals a pattern of daily use, who acquired tolerance. The purpose this study was examine the impact tolerance on acute as measured by time, (gap acceptance), Methods Participants (ages 25–45) completed tablet-based (iPad) test...
Background: Cesium chloride (CsCl) is sold as a treatment for several types of cancers. The purported mechanism action alkalinization relatively acidic neoplastic cells. efficacy CsCl has not been demonstrated in controlled experiments. Oral and intravenous use associated with seizures, cardiotoxicity, syncope, death. Although intratumoral various antineoplastic agents described, no cases cancer have found the medical literature. case described here appears to be first reported patient...
Introduction The determination of recent cannabis use is forensic interest in the investigation automotive crashes, workplace incidents and other mishaps. Because Δ9-tetrahydrocannabinol may persist blood after psychoactive effects intoxication resolve, particularly regular users, short-lived minor cannabinoids such as cannabigerol have merited examination adjunct indicators inhalation.Methods As part an observational cohort study, whole including were measured by liquid chromatography with...
Introduction Cannabis use is a growing concern in transportation and workplace incidents. Because Δ9-tetrahydrocannabinol detectable after acute psychoactive effects have resolved, it has limitations as an indicator of recent usage or potential impairment.
The goal of these sessions was to identify current practices and recommendations regarding medical surveillance for nanomaterial workers.Conference participants met in three discussion groups.There were few existing programs directed workers. Participants expressed a range views, from feeling that comprehensive is important currently suggesting targeted will become when more complete data are available assess risks.Results health outcomes research ultrafine air pollution toxicological...