A HIFU sequence with extremely short pulse duration and high repetition frequency can achieve thermal ablation at a low acoustic power using inertial cavitation. Because of its cavitation-dependent property, the therapeutic outcome is unreliable when treatment zone lacks cavitation nuclei. To overcome this intrinsic limitation, we introduced perfluorocarbon nanodroplets as extra nuclei into short-pulsed HIFU-mediated ablation. Two types were used perfluorohexane (PFH) core material coated...

Abstract Targeted delivery of drug‐loaded nanoparticles to brain tumors is exceptionally difficult due the blood‐brain barrier (BBB). In addition, several chemotherapeutic drugs induce autophagy, which protects cells from apoptosis and mitigates therapeutic effect. A novel “all‐in‐one” (AMPTL) consisting endogenous reactive oxygen species‐cleavable thioketal linkers conjugated paclitaxel (PTX) autophagy inhibitor 3‐methyladenine, angiopep‐2 peptide‐modified DSPE‐PEG 2K developed. AMPTL...

Nowadays, both thermal and mechanical ablation techniques of HIFU associated with cavitation have been developed for noninvasive treatment. A specific challenge the successful clinical implementation is to achieve real-time imaging evaluation determination therapy outcomes such as necrosis or homogenization. Ultrasound Nakagami-m parametric highlights degrading shadowing effects bubbles can be used tissue characterization. The aim this study investigate performance evaluating differentiating...

Purpose Passive acoustic mapping (PAM) has been proposed as a means of monitoring ultrasound therapy, particularly nonthermal cavitation‐mediated applications. In PAM, the most common beamforming algorithm is delay, sum, and integrate (DSAI) approach. However, using DSAI leads to low‐quality images for case where narrow‐aperture receiving array such standard B‐mode linear used. This study aims propose an enhanced linear‐array PAM based on multiply, (DMSAI). Methods algorithm, before...

Purpose Improvement of both the imaging resolution and contrast‐to‐tissue ratio ( CTR ) is a current emphasis contrast‐enhanced ultrasound CEUS for microvascular perfusion imaging. Based on strong nonlinear characteristics contrast agents, s have been significantly enhanced using various advanced methods. However, these methods limited by finite bandwidth process. This study aimed to propose bubble‐echo based deconvolution BED method with improved . Method The built modified convolution...

The Nakagami statistical model and shape parameter m have been widely used in linear tissue characterization preliminarily characterized the envelope distributions of nonlinear encapsulated microbubbles (EMBs). However, distribution scattering EMBs lacked a systematical investigation. Thus, this study aimed to investigate illustrate impact EMBs' nonlinearity on model.A group simulated EMB phantoms vitro dilutions with an increasing concentration under various nonlinearities, as regulated by...

The feasibility of utilizing high intensity focused ultrasound (HIFU) to induce thrombolysis has been demonstrated previously. However, clinical concerns still remain related the clot debris produced via fragmentation original potentially being too large and hence occluding downstream vessels, causing hazardous emboli. This study investigates use standing wave fields formed HIFU disintegrate thrombus while achieving a reduced size in vitro. results showed that average diameter calculated by...

Recently, passive acoustic mapping (PAM) has been successfully applied for dynamic monitoring of ultrasound therapy by beamforming emissions cavitation activity during exposure. The most widely used PAM algorithm in the literature is time exposure acoustics (TEA), which a standard delay, sum, and integrate algorithm. However, it results large point spread function (PSF) serious imaging artifacts case where narrow-aperture receiving array such as B-mode linear used, therefore degrading...

In this study, a unique method that combines the ultrafast active cavitation imaging technique with multiple bubble wavelet transform (MBWT) for improving detection contrast was presented. The constructed by modified Keller–Miksis equation considered mutual effect among bubbles. A three-dimensional spatial model applied to simulate distribution of effects four parameters on signal-to-noise ratio (SNR) images were evaluated, including following: initial radii bubbles, scale factor in...

Focused ultrasound ablation provides a truly noninvasive tumor treatment option with clinically proven feasibility and safety. However, the frequently required long duration hinders its clinical applicability. In this work, we compared thermal induced by conventional focused (cFUS), split-focus (sFUS), acoustic vortex (AV) in tissue phantoms containing phase-change nanodroplets mouse tumors. The results indicated that AV could substantially enhance efficiency cFUS, which was attributed to...

Purpose Passive acoustic mapping (PAM) has received increasing attention in recent years and an extremely widespread application prospect real‐time monitoring of ultrasound treatment. When using a diagnostic transducer, such as linear‐array the initially used time exposure acoustics (TEA) algorithm will produce high‐level artifacts. To address this problem, we recently proposed enhanced for PAM by introducing dual apodization with cross‐correlation (DAX) method into TEA. But due to that...

In recent years, cavitation is increasingly utilized in a wide range of applications biomedical field. Monitoring the spatial-temporal evolution bubbles great significance for efficiency and safety applications. this paper, several acoustic methods mapping proposed or modified on basis existing work will be presented. The novel ultrasound line-by-line/plane-by-plane method can depict distribution with high spatial temporal resolution may developed as potential standard 2D/3D field method....

Passive acoustic mapping (PAM) is a promising tool for monitoring cavitation activities in the applications of ultrasound therapy. Data-adaptive beamformers PAM have better image quality compared to time exposure acoustics (TEA) algorithms. However, computational cost data-adaptive considerably expensive. In this work, we develop deep beamformer based on generative adversarial network, which can switch between different transducer arrays and reconstruct high-quality images directly from...

While passive acoustic mapping (PAM) has been advanced for monitoring cavitation activity in focused ultrasound (FUS) therapy, achieving both real-time and high-quality imaging capabilities is still challenging. The angular spectrum (AS) method presents the most efficient algorithm PAM, but it suffers from artifacts low resolution due to diffraction pattern of array. Data-adaptive beamformers suppress well, their overwhelming computational complexity, more than two orders magnitude higher...

Real-time dynamic monitoring of cavitation is essential for the safety and efficiency high intensity focused ultrasound (HIFU) therapy. Unlike pulse-echo imaging, which can only be use while HIFU turned off, passive acoustic mapping (PAM) enable during exposure. But conventional used PAM has low resolution interference artifacts. For this, a unique algorithm that combines frequency-sum beamforming with robust Capon beamformer (FS-RCB-PAM) was proposed in this study.

Plantar fasciitis (PFis) is a common cause of heel pain. This study aims to assess the plantar fascia (PF) quantitatively by using feature descriptors and seek valuable imaging biomarkers that can reliably diagnose PFis. A total 63 participants underwent B-mode longitudinal shear wave elastography (SWE) on unilateral fasciae. To characterize statistical spatial texture features PF, ten modulus in standardized region interest PF twenty SWE measurement window (in both horizontal vertical...

Owing to acoustic-pressure dependence, amplitudes of backscattered-echoes encapsulated microbubbles (MBs) are unavoidably regulated by an uneven acoustic field, resulting in the misestimation hemodynamics conventional amplitude-coding dynamic contrast-enhanced ultrasound (DCEUS) with focused pulse transmission. This study aimed investigate feasibility and performance Nakagami statistical-feature parametric imaging recover above misestimation.Logarithmic parameter (m)-coding DCEUS scheme was...

Abstract Background Passive acoustic mapping (PAM) is showing increasing application potential in monitoring ultrasound therapy by spatially resolving cavitation activity. PAM with the relative time‐of‐flight information leads to poor axial resolution when implemented diagnostic transducers. Through utilizing absolute preserved transmit‐receive synchronization and applying common delay‐sum (DS) beamforming algorithm, can be greatly improved short‐pulse excitation scenario, as active imaging....

Vortex-based acoustic tweezer offer a novel particle manipulation method and has attracted extensive attention, its application potential in ultrasound therapies begun to be exploited. Cavitation exerts pivotal function therapies, the detection of spatiotemporal evolution vortex field is great significance for vortex-based therapies. Ultrasound-based passive cavitation mapping strong advantages over other methods terms detection, which applicable opaque media, can operate during irradiation,...

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Previous study has demonstrated that pulsed HIFU with tens of microseconds pulse duration (PD) and 10kHz PRF is effective for cavitation generation. Meanwhile, the assistance PFC nanodroplets, can be further enhanced. Despite higher efficiency, we also need to precisely controlled confined sake therapeutic safety, especially during implementation surgery in fine organs like brain, neuro, or blood vessel. Smaller focus obtained by designing very large spherical shaped transducers, which cause...

The previous study has demonstrated that pulsed HIFU with tens of microseconds pulse duration and 10kHz repetition frequency is effective for cavitation generation. With the assistance perfluorocarbon (PFC) nano-droplets, can be further enhanced. But despite higher efficiency, we also need precisely controlled sake therapeutic safety. In this work, propose a combinatorial ultrasound wave sequence to realize in PFC nano-droplets assisted ablation. applied was composed preconditioned...