Shanshan Xu

ORCID: 0000-0002-8236-7687
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About
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Research Areas
  • Ultrasound and Hyperthermia Applications
  • Photoacoustic and Ultrasonic Imaging
  • Ultrasound and Cavitation Phenomena
  • Spondyloarthritis Studies and Treatments
  • Psoriasis: Treatment and Pathogenesis
  • Ultrasound Imaging and Elastography
  • Autoimmune and Inflammatory Disorders Research
  • Rheumatoid Arthritis Research and Therapies
  • Climate Change and Health Impacts
  • Liver Disease Diagnosis and Treatment
  • Ultrasonics and Acoustic Wave Propagation
  • Immune Response and Inflammation
  • Cancer-related molecular mechanisms research
  • Dermatology and Skin Diseases
  • Air Quality and Health Impacts
  • Macrophage Migration Inhibitory Factor
  • Gastric Cancer Management and Outcomes
  • Traditional Chinese Medicine Studies
  • Optical Imaging and Spectroscopy Techniques
  • Biomarkers in Disease Mechanisms
  • FOXO transcription factor regulation
  • Lipid metabolism and disorders
  • Metastasis and carcinoma case studies
  • Bone and Joint Diseases
  • Gastrointestinal Tumor Research and Treatment

Beijing University of Chinese Medicine
2020-2025

Zhejiang Hospital
2025

Shandong First Medical University
2021-2024

Shenzhen University
2024

Shanxi Medical University
2024

South China Agricultural University
2023-2024

China University of Geosciences
2023-2024

Anhui Medical University
2014-2023

Texila American University
2023

Taizhou Central Hospital
2019-2023

Abstract Tissue hemoglobin oxygen saturation (i.e., oxygenation) is a functional imaging endpoint that can reveal variations in tissue hypoxia, which may be predictive of pathologic response subjects undergoing neoadjuvant chemotherapy. In this study, we used diffuse optical spectroscopic (DOSI) to measure concentrations oxyhemoglobin (ctO2Hb), deoxy-hemoglobin (ctHHb), total Hb (ctTHb = ctO2Hb + ctHHb), and (stO2 ctO2Hb/ctTHb) tumor contralateral normal from 41 patients with locally...

10.1158/0008-5472.can-12-0056 article EN Cancer Research 2012-07-10

Objectives To assess the therapeutic effects and safety of Tongxie Yaofang (TXYF) granules vs placebo as an alternative treatment for diarrhoea-predominant irritable bowel syndrome (IBS-D). We hypothesised that TXYF would improve clinical responses among patients with IBS-D. Design A randomised, double-blind, placebo-controlled, phase II, superiority trial. Setting Outpatients attending Fangshan Hospital, Beijing University Chinese Medicine, Beijing, China. Participants 96 eligible...

10.1136/bmjopen-2024-088410 article EN cc-by-nc-nd BMJ Open 2025-01-01

Inertial cavitation is crucial for the therapeutic effects of sonodynamic. Therefore, approaches that can induce highly efficient inertial should be benefit sonodynamic effect. Our previous study demonstrated activity achieved through combinatorial use a short-pulsed focused ultrasound (SPFU) sequence and perfluorohexane (PFH) nanodroplets. Herein, we applied SPFU PFH nanodroplets in A hydrophobic sonosensitizer, IR780 iodine, was loaded inside denatured bovine serum albumin-shelled...

10.1016/j.ultsonch.2018.12.021 article EN cc-by-nc-nd Ultrasonics Sonochemistry 2018-12-12

Long non-coding RNA (lncRNA) H19 is associated with inflammatory diseases, but the molecular mechanism of in process ankylosing spondylitis (AS) unclear. Here, we investigated role and its downstream molecules inflammation AS by microarray analysis, qRT-PCR, western blot, dual-luciferase reporter assay. small interfering (siRNA) (Si-H19) adenovirus (AD-H19) were used to decrease increase expression, respectively. 42 annotated lncRNAs identified, was overexpressed. H19, vitamin D receptor...

10.1016/j.omtn.2019.11.025 article EN cc-by-nc-nd Molecular Therapy — Nucleic Acids 2019-11-29

This study aimed to investigate whether Forkhead box O3a (FOXO3a) modulates inflammation and oxidative stress in ankylosing spondylitis (AS). We applied bioinformatics analysis, quantitative real-time polymerase chain reaction, immunoblotting, enzyme linked immunosorbent assay, chromatin immunoprecipitation, dual-luciferase reporter assay. Gene overexpression knockdown of FOXO3a were conducted via lentivirus small interfering RNA, respectively. Downregulated expression was first confirmed AS...

10.3389/fimmu.2022.935534 article EN cc-by Frontiers in Immunology 2022-06-17

The aim of this study was to investigate the inertial cavitation inside a phantom treated by pulsed HIFU (pHIFU). Basic bovine serum albumin (BSA) phantoms without any inherent ultrasound contrast agents (UCAs) or phase-shift nano-emulsions (PSNEs) were used. During treatment, sonoluminescence (SL) recordings performed characterize spatial distribution adjacent focal region. High-speed photographs and thermal coagulations, comparing with SL results, also recorded presented. A series pulse...

10.1016/j.ultsonch.2016.02.025 article EN cc-by-nc-nd Ultrasonics Sonochemistry 2016-03-01

Cavitation is considered as the primary mechanism of soft tissue fragmentation (histotripsy) by pulsed high-intensity focused ultrasound. The residual cavitation bubbles have a dual influence on histotripsy pulses: these serve nuclei for easy generation new cavitation, and act strong scatterers causing energy “shadowing.” To monitor in histotripsy, an ultrafast active imaging method with relatively high signal-to-noise ratio good spatial-temporal resolution was proposed this paper, which...

10.1121/1.4919286 article EN The Journal of the Acoustical Society of America 2015-05-01
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