A5103030231- Spondyloarthritis Studies and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Asthma and respiratory diseases
- Heavy Metal Exposure and Toxicity
- Connective tissue disorders research
- Autophagy in Disease and Therapy
- MXene and MAX Phase Materials
- Bone Metabolism and Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psychological Well-being and Life Satisfaction
- Ion Transport and Channel Regulation
- Peptidase Inhibition and Analysis
- Skin and Cellular Biology Research
- Hereditary Neurological Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Urticaria and Related Conditions
- Semiconductor materials and devices
- Autoimmune and Inflammatory Disorders Research
- Health disparities and outcomes
- Maternal Mental Health During Pregnancy and Postpartum
- Wnt/β-catenin signaling in development and cancer
Anhui Medical University
2018-2024
Ministry of Education of the People's Republic of China
2024
Second Military Medical University
2018-2023
Changhai Hospital
2018-2023
Qingzhou City People's Hospital
2015
Nankai University
2007
The acidic tumor microenvironment (TME) of pancreatic cancer affects the physiological function stellate cells (PSCs), which in turn promotes progression. Acid-sensing ion channel 1a (ASIC1a) is responsible for acidosis-related physiopathological processes. In this study, we investigated effect acid exposure on activation and autophagy PSCs, role ASIC1a these events. results showed that medium upregulated expression ASIC1a, induced PSCs autophagy, can be suppressed by inhibiting using PcTx1...
Acid-sensing ion channel 1a (ASIC1a), as a member of the proton-gated cation family, can be activated by low extracellular pH, and takes part in many acidity-associated physiopathological processes. However, whether ASIC1a is expressed human pancreatic stellate cells (PSCs) involved acid-induced events has not been reported yet. In this study, we investigated expression PSCs its possible role activation autophagy evoked acid. Our results show that present PSCs, an enhanced occurs under acid...
Previous studies have indicated a correlation between maternal imbalances in essential trace elements during pregnancy and the occurrence of spontaneous abortion (SA). Nonetheless, impact these from both partners preconception period remains unexplored.
Objectives: To explore the genetic interaction between Wnt/β-catenin signalling pathway genes and ankylosing spondylitis (AS) in Chinese population.Methods: Six single-nucleotide polymorphisms (SNPs) DKK1, LRP5, LRP6, SOST were genotyped 673 AS patients 687 healthy controls by using SNPs can Technic. Single marker association analysis was performed. Haplotypes constructed after linkage disequilibrium analysis; additive, multiplicative, higher-order interactions analysed.Results: The DKK1...
Behavioral patterns are sometimes associated with depression symptoms; however, few studies have considered the intra-couple effects. This study examined effect of a spouses' behavioral on symptoms within themself and in their spouse.A total 61,118 childbearing age participants (30,559 husband-wife dyads) were surveyed. The assessed using nine-item Patient Health Questionnaire (PHQ-9). identified by latent class analysis. effects couple's own (actor effect) partner's (partner analyzed...
Background: Asthma is observationally associated with an increased risk of COVID-19, but the causality remains unclear. We aim to determine whether there a casual role asthma in susceptibility SARS-CoV-2 infection or COVID-19 severity. Methods: Instrumental variables (IVs) for and moderate-to-severe were obtained from publicly available summary statistics most recent largest genome-wide association study (GWAS), including 394 283 57 695 participants European ancestry, respectively. The...