The depletion of striatal dopamine (DA) that can occur after methamphetamine (METH) administration has been linked to METH-induced hyperthermia. relationship between hyperthermia, neurotoxicity (striatal DA depletions) and compounds protect against METH was further investigated in this study. Typically, rats exposed die when their body temperatures exceed 41.3 degrees C but such hyperthermic be saved by hypothermic intervention. Subsequently, intervention have greater at an earlier time...

The effects of developmental age on (+/-)-3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in 5-hydroxytryptamine (5-HT) content and 5-HT reuptake sites were investigated conjunction with the MDMA-induced thermoregulatory responses. MDMA was administered to rats at postnatal days (PND) 10, 40 70 a range ambient temperature environments (10 degrees C, 25 C 33 C). Animals monitored for alterations body sacrificed 1 week after administration. administration PND 10 did not result...

Use of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) has increased dramatically in recent years, yet little is known about its effects on the developing brain. Neonatal rats were administered MDMA days 1-10 or 11-20 (analogous to early and late human third trimester brain development). exposure had no effect survival but did affect body weight gain during treatment. After treatment, largely recovered 90-95% controls. resulted dose-related impairments sequential learning spatial memory,...

The neurotoxic effects of methamphetamine (MA) on dopaminergic and serotonergic terminals have been well-documented. Another effect MA is neuronal degeneration in the somatosensory cortex, as seen by silver staining. neurochemical characteristics these degenerating neurons are unknown. Using glutamate glial fibrillary acid protein (GFAP) immunohistochemistry, it was found that exposure adult rats (10 mg/kg given 4 times intraperotoneally(i.p.) at 2-h intervals) causes localized depletion...

Abstract In previous studies, we have shown that P11‐20 treatment with D ‐methamphetamine (MA) (10 mg/kg × 4/day at 2‐h intervals) induces impairments in spatial learning and memory the Morris water maze after offspring reach adulthood. Using a split‐litter, multiple dose, design (0, 5, 10, 15 MA administered s.c. intervals), effect was further explored shifted platform (reversal), reference memory‐based procedure working procedure. Prior to learning, animals were first tested for swimming...

Dopaminergic innervation to the nucleus accumbens was investigated following a neurotoxic regimen of methamphetamine (MA) treatment. Four 10 mg/kg doses MA were administered s.c. male Sprague-Dawley rats with 2 h interval between doses. Rectal temperatures monitored for induction MA-induced hyperthermia. Three days or weeks after treatment animals sacrificed by transcardial perfusion and processed tyrosine hydroxylase (TH-IR) glial fibrillary acidic protein immunoreactivity (GFAP-IR)....

The effects of neonatal d -methamphetamine (MA) treatment on cued and spatial learning memory were investigated. MA was administered to rats postnatal days 11–20. All groups received four subcutaneous injections per day. Group MA40–4 40 mg · kg −1 in divided doses (10 mg/kg injection). MA40–2 two (20 mg/kg/injection) saline for the other Controls As adults, both showed no differences swimming ability a straight channel. group learning, but impaired hidden platform Morris water maze...

Tissue levels of serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA) and populations 5-HT reuptake sites were measured in the brains rats exposed to 3,4-methylenedioxymethamphetamine (MDMA) at selected developmental ages. MDMA exposure postnatal day (PND) 10 did not result altered or 5-HIAA 1 week after administration any brain region examined. However, PND 40 70 resulted dose-dependent reductions all regions Time course studies revealed that 10, acutely (< = 24 hr) reduced...

Abstract The effects of the dopamine D 1 receptor antagonist R(+)‐SCH‐23390 and 2 S(–)‐eticlopride on d‐methamphetamine‐induced striatal monoamine reductions 72 h after treatment were investigated in relation to changes body temperature. Rats administered four 10‐mg/kg doses d‐methamphetamine or saline with a 2‐h interval between treatments; 0.5 mg/kg eticlopride SCH‐23390 was 15 min before each methamphetamine injection. Two ambient temperature conditions investigated: 24 33°C....

Methamphetamine (MA) administration to adult rats (4 × 10 mg/kg s.c.) induces neurotoxicity predominately characterized by a persistent reduction of neostriatal dopamine (DA) content. Hyperthermia following MA potentiates the resulting DA depletion. DA-derived free radicals are postulated be mechanism through which MA-induced is produced. The spin trapping agent PBN reacts with form nitroxyl adducts, thereby preventing damaging radical reactions cellular substrates. saline pretreatment...

Fluoro-Gold (FG), first developed as an antifungal/antiparasitic agent, is now also used extensively a retrograde tracer in histological studies of nervous tissue. The fact that FG taken up by dopamine (DA) terminals before its transport to DA cell bodies implies presynaptic interaction, though the biochemical target(s) and mechanism(s) are unknown. To further elucidate, another aromatic diamidine, pentamidine, were tested on [3H]DA release uptake vitro from striatal slices synaptosomes....

Abstract In order to investigate methamphetamine (MA)‐induced neurotoxicity, two studies were carried out. the first study, MA‐induced neostriatal monoamine depletions in male and female Sprague‐Dawley CD rats studied under conditions which magnitude of hyperthermia was comparable between sexes. MA (5 or 10 mg/kg) saline (3 ml/kg) administered s.c. four times at hr intervals. Rectal temperatures monitored for 9 hours a room with an ambient temperature 23° 2°C. Animals sacrificed three days...