A5000063565- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Pneumonia and Respiratory Infections
- Muscle Physiology and Disorders
- Radiology practices and education
- Rabies epidemiology and control
- Chemotherapy-induced cardiotoxicity and mitigation
- Clinical Nutrition and Gastroenterology
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Bartonella species infections research
- Drug-Induced Ocular Toxicity
- Cardiac and Coronary Surgery Techniques
- Dermatological diseases and infestations
Hospital for Sick Children
2020-2024
SickKids Foundation
2024
Stanford University
2019-2024
University of Toronto
2020-2024
Southwestern Medical Center
2021-2023
The University of Texas Southwestern Medical Center
2021-2023
Children's Medical Center
2021-2022
University of Calgary
2015-2021
Alberta Children's Hospital
2015-2020
Palo Alto University
2020
Hypertrophic cardiomyopathy (HCM) can be associated with an abnormal exercise response. In adults HCM, results on stress testing are predictive of heart failure outcomes. Our goal was to determine whether response is adverse outcomes in pediatric patients HCM. international cohort study including 20 centers, phenotype-positive primary HCM who were <18 years age at diagnosis included. Abnormal defined as a blunted blood pressure and new or worsened ST- T-wave segment changes complex...
Construct: Clinical reasoning assessment is a growing area of interest in the medical education literature. Script concordance testing (SCT) evaluates clinical conditions uncertainty and has emerged as an innovative tool domain assessment. SCT quantifies degree between learner experienced clinician attempts to capture breadth responses expert clinicians, acknowledging significant yet acceptable variation practice under situations uncertainty. Background: been shown be valid reliable tool....
Advances in medical care for patients with Duchenne muscular dystrophy (DMD) have resulted improved survival and an increased prevalence of cardiomyopathy. Serial echocardiographic surveillance is recommended to detect early cardiac dysfunction initiate therapy. Clinical anecdote suggests that quality diminishes over time, impeding accurate assessment left ventricular systolic function. Furthermore, evidence-based guidelines the use imaging DMD, including magnetic resonance (CMR), are...
Background Heart-healthy lifestyles promote lifelong cardiovascular health. However, patients with hypertrophic cardiomyopathy are often advised to avoid strenuous exercise because of the risk sudden cardiac death. Given these restrictions, this study explored youth and parent perceptions a heart-healthy lifestyle barriers facilitators lifestyle. Methods Results Youth parents were purposefully recruited at 2 Canadian hospitals for photovoice project. Participants given cameras took pictures...
To determine which echocardiographic features of hypoplastic left heart complex (HLHC) in the fetal period are predictive biventricular (BV) circulation and to evaluate long-term outcome patients with HLHC, including rates mortality, reintervention development further cardiac disease.Echocardiograms fetuses HLHC obtained at 18-26 weeks 27-36 weeks' gestation between 2004 2017 were included analysis. The primary was successful BV (Group 1). Group 2 single-ventricle palliation, death or...
Rejection remains an important cause of morbidity and mortality after pediatric heart transplantation (HT). Endomyocardial biopsy (EMB) is the gold standard for rejection diagnosis, but it comes with procedural risk. The frequency EMB varies significantly across centers. Since April 2018, our center's surveillance schedule based on a risk prediction score employing age, pre-HT panel reactive antibodies (PRA). We aimed to evaluate outcomes in 1st year post-HT before implementation.
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular condition caused by mutations in the dystrophin gene leading to skeletal muscle weakness and dilated cardiomyopathy. The prevalence of DMD-related cardiomyopathy increases with age almost universal third decade life. Myocardial fibrosis progressive left ventricular dysfunction lead development heart failure premature death. With modern advances medical surgical management for patients DMD increasing their life expectancy, cardiac...
Abstract Background Malnutrition is common among children with single ventricle (SV) congenital heart disease (CHD). The impact of transplantation (HT) on nutritional status in SV patients understudied. Our aim was to evaluate anthropometric changes after HT, compared those transplanted for cardiomyopathy (CM). Methods We performed a single‐center retrospective chart review and CM < 18 years who underwent HT from January 01, 2010 December 05, 2017. Wasting stunting were defined as...
Background: Physical activity (PA) is a mainstay for cardiovascular health. However, those with hypertrophic cardiomyopathy (HCM) are often counselled to limit PA due the potential risk of sudden cardiac death. The emphasis placed on restriction has put this population more susceptible acquired (CV) factors, and poor long-term CV health from physical inactivity. To date, no consensus exists about what appropriate safe in terms exercise population. Project Aim: Use modified Delphi method gain...
Bartonella quintana is a rare but important cause of culture-negative endocarditis, classically associated with body lice infestation. We report the first known pediatric case endocarditis head lice. The importance sending targeted testing for this organism in at-risk patients, ideally on tissue specimens, emphasized.
Children on ventricular assist device (VAD) support can present several unique challenges, including small patient size, univentricular or biventricular congenital heart disease (1V- 2V-CHD) and need for VAD (BiVAD) support. While cardiac catheterization provide valuable information, it is an invasive procedure with inherent risks. We sought to evaluate the safety of in pediatric patients performed a retrospective review who underwent at Lucile Packard Children's Hospital between January 1,...