A5026488971- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Nuclear Physics and Applications
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Particle Detector Development and Performance
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- Digital Radiography and Breast Imaging
Instituto de Instrumentación para Imagen Molecular
2016-2023
Universitat Politècnica de València
2017-2021
Consejo Superior de Investigaciones Científicas
2019
Clinical and organ-dedicated PET systems typically require a high efficiency imposing the use of thick scintillators, normally through crystal arrays. To provide depth interaction (DOI) information, two or more layers are sometimes mounted in staggered phoswich approach. In this paper, we proposing an alternative using large monolithic crystals. We have tested surface treatments for 50 mm × 20 LYSO block. data paper as close 5 to lateral walls. left those walls black painted exit face...
Hybrid molecular and anatomical imaging devices, especially when simultaneously working, have shown to provide advantages over sequential acquisitions. In particular, we present in this preliminary study, the working performance of a brain positron emission tomography (PET) insert, within 3T magnetic resonance (MRI) system. To our knowledge, is largest PET system based on monolithic LYSO blocks. It consists 60 scintillator blocks <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...
There are drawbacks with using a Positron Emission Tomography (PET) scanner design employing the traditional arrangement of multiple detectors in an array format. Typically PET systems constructed many regular gaps between detector modules ring or box configuration, additional axial rings. Although this has been significantly reduced use compact high granularity SiPM photodetector technology, such leads to decrease number annihilation photons that detected causing lower sensitivity....
Abstract Background Prostate cancer (PCa) represents one of the most common types cancers facing male population. Nowadays, to confirm PCa, systematic or multiparametric MRI-targeted transrectal transperineal biopsies prostate are required. However, due lack an accurate imaging technique capable precisely locate cancerous cells in prostate, ultrasound sample random parts and, therefore, it is possible miss regions where those present. In spite improvement with MRI, low reproducibility its...
Improving sensitivity and spatial resolution in small animal Positron Emission Tomography imaging instrumentation constitutes one of the main goals nuclear research. These parameters are degraded by presence gaps between detectors. The present manuscript experimentally validates our prototype an edge-less pre-clinical PET system based on a single LYSO:Ce annulus with inner diameter 62 mm 10 outer facets 26 × 52 mm2. Scintillation light is read out arrays 8 SiPMs coupled to facets, using...
Total Body Positron Emission Tomography (TB-PET) scanners provide high-quality images due to the large sensitivity. Our motivation is design a TB-PET system with up 70 cm axial coverage that mitigates parallax error degradation by using detector concept based on semi-monolithic LYSO crystals. Furthermore, this approach allows simultaneously reach an accurate Coincidence Time Resolution (CTR) enhance image quality means of Flight (TOF) reconstruction algorithms. We have simulated and compared...
Fast timing in gamma-ray detectors is pivotal to enable accurate time-of-flight (TOF) Positron Emission Tomography (PET). While electronics already can reach intrinsic capabilities well below 50 ps, and photosensors also provide performances, scintillators lag behind. Herein, order achieve sufficient sensitivity, dense inorganic crystals such as LYSO or BGO with thicknesses of 10–30 mm are required. The response relatively slow, about 40 300 ns, respectively. Alternative these crystals,...
The aim of this work is to show the potential capabilities monolithic crystals coupled large SiPM arrays, be considered as detector blocks for PET scanners enabling Time Of Flight (TOF) capabilities. Monolithic allow one decode 3D photon impact position. This approach, along with TOF information, can high interest in clinical Positron emission tomography (PET) applications where a typical ring configuration used. In manuscript, we evaluate an ASIC- based readout digitizing all signals coming...
Recently, two novel PET devices have been developed with open geometries, namely: breast and prostate-dedicated scanners. The breast-dedicated system comprises detector rings of twelve modules a field view 170 mm × 94 mm. Each module consists continuous trapezoidal LYSO crystal PSPMT. has the capability to vary opening up 60 in order allow insertion needle perform biopsy procedure. prostate an geometry consisting on parallel plates separated 28 cm. One panel includes 18 detectors organized 6...
In the past years, gamma-ray detector designs based on monolithic crystals have demonstrated to be excellent candidates for design of high-performance PET systems. The allow achieve intrinsic resolutions well below state-of-the-art; increase packing fraction thus, increasing system sensitivity; and improve lesion detectability at edges scanner field view (FOV) because their depth interaction (DOI) capabilities. bottleneck translate clinical systems a large number detectors is eventually...
Total-Body Positron Emission Tomography (TB-PET) technology and designs have become very popular in recent years. The advantages of these systems are many, pinpointing the high sensitivity achieved by their long axial FOV eventually TOF, capabilities to simultaneously study kinetics multiple organs. Most TB-PET implementations based on LYSO crystal pixels without DOI. In this work we present a system semi-monolithic crystals and, therefore, enabling TOF depth interaction capabilities....
In this work we are describing a novel approach to the scintillator crystal configuration as used in nuclear medicine imaging. Our design is related coupling one PET module of two separate configurations so far there: monolithic and arrays. The particular have studied based on two-layer (hybrid) composed LYSO (5–6 mm thickness) array with 4–5 height (0.8 1 pixels). We show here detector block performance, terms spatial, energy DOI information, be scanners. propose allows achieve accurate...
A whole-body PET device is sometimes not suitable for brain studies because the achieved image resolution typically sufficient to investigate small size structures. Thus, a dedicated insert system with high performance would overcome such limitations. Moreover, these functional lack of anatomical information. It shown elsewhere convenience simultaneously acquisition and MR data. In this work we show final design first pilot evaluation tests novel insert. Each detector block based on...
The main aim of this work is to provide a method retrieve the intrinsic resolution detector blocks based on monolithic crystals in fully assembled scanner. This suggests software collimation original data. results are compared with traditional approach separating two far enough, resulting geometrical collimation.An empirical equation has been deduced fit experimental data which follows Gaussian distribution and contribution source, given small size 0.25 mm diameter, Lorentzian profile....
In PET systems with a geometry different from closed ring, the Time of Flight (TOF) annihilation photons appears to be relevant. Such system capability helps compensate missing angular information that generates artifacts on reconstructed images. this work, two ASIC designs are evaluated for their use in having accurate coincidence resolving times (CRT) while preserving both energy and spatial resolutions. One options is TOFPET1 PETsys other so-called PETIROC2 Weeroc. Detection blocks based...
The aim of this work is to show the potential capabilities monolithic-based LYSO crystals, coupled large SiPM arrays be considered as detector blocks for TOF-PET scanners. An ASIC read-out with accurate timing used independently process each SIPM element. Several studies have been carried out using both crystal and monolithic showing an overall good performance. most relevant parameters evaluated in are: spatial, energy time resolutions. We obtained coincidence resolving times 340 ps FWHM...
In this manuscript, detector blocks for Positron-Emission-Tomography (PET) are being evaluated their integration in a TOF-PET system. contribution, concepts based on analog SiPM photosensors have been tested along with different types of scintillation materials. Firstly, pixelated crystals showing accurate results terms spatial, energy and timing resolution. Then, monolithic were coupled to large arrays determine capabilities resolve the gamma impacts position timing. The read-out digitation...
This work presents a conceptual design for Total Body (TB) PET scanner. Although, we show some experimental data obtained with preliminary detector block configuration, the main focus in this contribution is about system results based on Monte Carlo simulations. The blocks are an array of semi-monolithic LYSO crystals (slabs). Such slab configuration enhances Coincidence Time Resolution (CTR) comparison monolithic and, moreover, allows one to estimate impact Depth Interaction (DOI).In work,...
A direct ray tracing algorithm has been proposed under the development of a dedicated brain PET insert scanner, called MindView. The presented method takes advantage quasi- continuum nature impact coordinates provided by detectors composed monolithic scintillation crystals (LYSO material). This requires two-step filtering process: first, Butterworth filter, multiplied ramp is applied on reconstructed image to wipe out low oversampled frequencies after performing backprojection, and second,...
Motion correction algorithms are necessary in PET studies where the patient cannot remain totally static. Otherwise, artifacts appear final reconstructed image, degrading spatial resolution or even misplacing radiation distribution source. In this work we propose a new enhanced motion algorithm (EMAF) based on multiple acquisition frames (MAF). This methodology can be applied to two system geometries (a ring and multi-panel system). Using simulated data, comparison of static corrected...
In gamma ray imaging, a scintillation crystal is typically used to convert the radiation into visible light. Photosensors are transform this light measurable signals. Several types of photosensors currently in use depending on application, most known Position Sensitive Photomultiplier Tubes (PSPMT) or arrays Silicon Photomultipliers (SiPMs). There have been investigations towards reducing number output signals from those order decrease system costs and complexity without impacting...