A5019624927- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Nuclear Physics and Applications
- Advancements in PLL and VCO Technologies
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Radiation Effects in Electronics
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Laser-Matter Interactions and Applications
- Solar and Space Plasma Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Engineering Education and Pedagogy
- Neuroblastoma Research and Treatments
- Robotic Mechanisms and Dynamics
- Advanced NMR Techniques and Applications
- Dark Matter and Cosmic Phenomena
- Particle Detector Development and Performance
- Sensor Technology and Measurement Systems
- High-pressure geophysics and materials
- Magnetic Properties of Alloys
- Advanced Optical Sensing Technologies
Instituto Nacional de Neurología y Neurocirugía
2025
Efacec (Portugal)
2016-2018
Instituto de Instrumentación para Imagen Molecular
2015-2017
Universitat Politècnica de València
2015-2017
Consejo Superior de Investigaciones Científicas
2015
Universitat de València
2012-2014
Background Oligodendrogliomas are a distinct subtype of gliomas frequently characterized by the 1p/19q codeletion and isocitrate dehydrogenase (IDH) gene mutations, both associated with improved therapeutic response prolonged survival. These genetic alterations modulate transsulfuration pathway, leading to increased methionine uptake tumor cells. Positron emission tomography (PET) 11C-labeled (MET PET) leverages these metabolic changes, providing noninvasive means distinguish...
This contribution describes an accurate approach implementing a Time-to-Digital Converter using Field-Programmable Gate Array (FPGA) device. Time differences with FWHM better than 100 ps for 24 pairs of channels working simultaneously have been achieved. was possible through the proper management FPGA internal resources and by device calibration process minimizing effect temperature voltage fluctuations. The system results time between multiple are presented. current suggests possibility...
In this work we show pilot tests of PET detector blocks using the TOF-PET ASIC, coupled to SiPM arrays and different crystal configurations. We have characterized main ASIC features running calibration processes compensate time dispersion among ASIC/SiPM paths as well for walk on arrival optical photons. The aim is use LYSO monolithic crystals explore their photon Depth Interaction (DOI) capabilities, keeping good energy spatial resolutions. First been carried out with arrays. Here made it...
We report on benchmark tests of a 3 TW/50 fs, table-top laser system specifically developed for proton acceleration with an intrinsic pump rate up to 100 Hz. In two series single-shot measurements differing in pulse energy and contrast the successful operation diode pumped is demonstrated. Protons have been accelerated 1.6 MeV interactions pulses focused aluminium mylar foils between 0.8 25 μm thickness. Their spectral distributions maximum energies are consistent former experiments under...
Background and objectives: Laser-plasma acceleration of protons ions is often considered a promising technique for compact applications highly intense beams multi-MeV particles. A remarkable example the on-site production short-lived radioisotopes medical preclinical interventions. We study quantitatively activity four important PET isotopes which may be obtained by irradiation suitable target nuclei with laser-accelerated deuterons. These simulations allow confining range useful parameters...
In this work the implementation of a Time-to-Digital Converter (TDC) using Nutt delay line FPGA-based and applied on Positron Emission Tomography (PET) device is going to be presented in order check system's suitability for Time Flight (TOF) measurements. recent years, FPGAs have shown great advantages precise time measurements PET. The architecture employed these described detail. system developed was tested dedicated breast PET prototype, composed LYSO crystals Positive Sensitive...
The multifunctional spectrometer (MFS) is a new radiation monitor that together with component technology test bed makes the European Space Agency Alphasat Environment and Effects Facility-Technology Demonstration Payload 8 (AEEF-TDP8). two units are hosted in X panel of satellite orbit since July 2013. MFS an instrument specifically designed to characterize space environment geostationary orbit. mission lifetime AEEF/TDP8 will be at least three years TDP8 expected acquiring scientific data...
In this work we are describing a novel approach to the scintillator crystal configuration as used in nuclear medicine imaging. Our design is related coupling one PET module of two separate configurations so far there: monolithic and arrays. The particular have studied based on two-layer (hybrid) composed LYSO (5–6 mm thickness) array with 4–5 height (0.8 1 pixels). We show here detector block performance, terms spatial, energy DOI information, be scanners. propose allows achieve accurate...
Developing front-end electronics to improve charge detection and time resolution in gamma-ray detectors is one of the main tasks performance new multimodal imaging systems that merge information Magnetic Resonance Imaging Gamma Camera or PET tomographs.
In this contribution, Coincidence Resolving Time (CRT) results with the developed multichannel FPGA-TDC are showed as a function of different configurations for both, sensor bias voltage and digitizer threshold. The dependence CRT matrix temperature, amount SiPM active area crystal type also analyzed. Preliminary measurements carried out array 2 mm pixel size 10 height have shown time resolutions entire 144 two-detectors ensemble good 800 ps.
Current PET detectors have a very low sensitivity, of the order few percent. One reasons is that Compton events are being rejected. In this work we aim to prove rich source additional information can play crucial role in image reconstruction process. With data, detector sensitivity will be substantially improved and thus, applied dose on patient also reduced. This could really breaking point for technology as one should able obtain better quality with less radiation. By means cone matching...
A histological intraoperative analysis of tissue specimen is usually required for evaluation sentinel lymph node (SLN) and determination margins surgical resection. Currently, this performed by Touch Imprint Cytology (TIC), Frozen Section (FS) analysis, scrape cytology or a combination these methods. We propose an alternative approach based on Magnetic Resonance Imaging (MRI). In particular, in contribution we present the development, components, characterization as well first images...
In this work, a direct image reconstruction algorithm for PET is proposed. This method follows naturally from the concept of LOR, and easily admits depth interaction time flight information. addition, does not require computation sinograms or system matrix. Thus, it restricted in formation high pixel density images allows real-time (simultaneously to data acquisition process). One key advantages preservation frequencies, producing accurate that can be generated resolution, because lack space...
This paper describes the results obtained with a new method for medical image reconstruction computed tomography (CT): QR-Decomposition. QR-Decomposition is model based (MB) algorithm like maximum likelihood expectation maximization (MLEM) but not iterative. It can be classified as model-based direct (MBDiR) algorithm. The takes advantage of benefits MB approach, only requires matrix vector multiplication and backward substitution reconstruction. Noise power spectrum (NPS) three dimensional...
The multifunctional spectrometer (MFS) is a radiation monitor installed on the X panel of Alphasat satellite, in geostationary orbit (GEO) since July 2013. MFS was specially tailored to characterize space environment GEO and it expected acquire scientific data during total lifetime five years. An end-to-end Geant4 simulation flight model based full geometry MFS, imported from computer-aided design (CAD) description markup language, implemented validated with ground-test results obtained Paul...
Background: The interaction of highly intense laser pulses with solid targets covers a wide range phenomena over several orders magnitude in intensity. Time-of-flight measurements provide an accurate reconstruction the ion energy spectra. We report on observation aluminium ions from laser-plasma by scintillator-based detector adjustable dynamic range. Methods: Data have been taken at 30 fs, 200 TW pulsed Ti:Sapphire focused foils 1.8 and 12.5 μm thickness. A time-of-flight consisting plastic...
Magnetic Resonance Imaging (MRI) is a widely used technique to obtain images in different applications based on the nuclear magnetic renonance (NMR) phenomenon. Gradient coils are responsible components for encoding volume of interest (VOI). Linearity, inductance and resistance taken account perform gradient coil design. In this work, EM thermal properties studied two cooling system presented cool them. Finally, tested biplanar permanent magnet 2D phantom image obtained.
This contribution shows how to perform Time of Flight (TOF) measurements in Positron Emission Tomography (PET) systems using low-cost Field-Programmable Gate Array (FPGA) device with a resolution better than 100 ps. is achieved proper management the FPGA internal resources and an extremely careful calibration process including both temperature voltage compensation. The results system different time between multiple channels are presented.
The use of monolithic crystals to detect the incident gamma photons for PET imaging has flexibility virtually define detector pixel size. These pixels determine Lines Of Response (LORs) needed during reconstruction process. Although there are very few groups using PET, most common approach is homogeneously dimensions virtual forming a regular grid on crystal. In this work we present dimensional gradient method improve response model. typical spatial resolution degradation caused by border...
The MFS (Multi-Functional Spectrometer) is a radiation monitor that together with CTTB (Component Technology Test Bed) make the AEEF-TDP8 (ESA Alphasat Environment and Effects Facility - Demonstration Payload 8). two units are hosted in X panel of satellite orbit since July 2013. an instrument specifically designed to characterise Space Radiation environment while was built effect on electrical components (GaN transistors, Memories Optical Transceivers) geostationary orbit. mission lifetime...
Gradient coils are a main part of Magnetic Resonance Imaging (MRI) system. The aim gradient in MRI system is to encode spatially the Field View (FoV). Different coil design methods have been presented last years. Some factors such as linearity, inductance and resistance must be taken account obtain an optimized for coils. A combinatorial method presented. developed uses very simple shapes path pattern it allows finding best time less than 2 minutes. Path combination which generates highest...