A5038650577- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Digital Radiography and Breast Imaging
- Radiopharmaceutical Chemistry and Applications
- Laser-Matter Interactions and Applications
- High-pressure geophysics and materials
- Advanced X-ray Imaging Techniques
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Particle Detector Development and Performance
- Lung Cancer Diagnosis and Treatment
- Advanced Semiconductor Detectors and Materials
- Magnetic Properties of Alloys
- CCD and CMOS Imaging Sensors
- Paleontology and Stratigraphy of Fossils
- Geological and Geophysical Studies Worldwide
- Machine Learning in Materials Science
Instituto de Instrumentación para Imagen Molecular
2015-2024
Universitat Politècnica de València
2013-2022
Consejo Superior de Investigaciones Científicas
2013-2019
Centro Nacional de Aceleradores
2013
Motion Control (United States)
2013
Instituto de Física Corpuscular
2010-2011
Universitat de València
2010
Purpose: A breast dedicated positron emission tomography (PET) scanner has been developed based on monolithic LYSO crystals coupled to position sensitive photomultiplier tubes (PSPMTs). In this study, we describe the design of PET system and report its performance evaluation. Methods: MAMMI is a crystals. It consists 12 compact modules with transaxial field view (FOV) 170 mm in diameter 40 axial FOV that translates cover up mm. The patient lies down prone facilitates maximum elongation....
Gamma cameras are of great interest due to their high potential in the field Nuclear Medicine Imaging. They allow for an early diagnosis reduced size tumors, and also a wide variety preclinical studies with aim designing more effective treatments against cancer. In this work we propose significantly improved multi-pinhole collimator gamma camera perform first Monte Carlo analysis its characteristics. Maintaining configuration degree overlapping (thus sensitivity), add new element, active...
We report on the progress a first generation of realistic size metascintillators for time-of-flight PET. These heterostructures combine dense LYSO or BGO plates, interleaved with fast scintillator layers producing bunch prompt photons from energy leakage recoil photoelectric electron. From Geant4 simulation sharing distribution between and 42 LYSO-based BGO-based configurations, detailed study timing performance has been performed selection most promising 12 14 metascintillators. A Monte...
The authors have developed a trimodal PET∕SPECT∕CT scanner for small animal imaging. gamma ray subsystems are based on monolithic crystals coupled to multianode photomultiplier tubes (MA-PMTs), while computed tomography (CT) comprises commercially available microfocus x-ray tube and CsI scintillator 2D pixelated flat panel detector. In this study the will report design performance evaluation of multimodal system.X-ray transmission measurements performed cone-beam geometry. Individual...
A new small animal PET based on SiPM and monolithic LYSO crystals has been developed. Eight detector modules form the ring, each mounting an array of 12 × SiPMs coupled to a readout providing summed signals pixels rows columns array. This design makes it possible accurately determine centroid scintillation light distribution with about 1.6 mm full width at half maximum (FWHM) resolution without correction for 1 source size, photon depth interaction (DOI) nearly 2 FWHM. single ring system...
Abstract This article presents system performance studies of the CareMiBrain dedicated brain PET according to NEMA NU 2-2012 (for whole-body PETs) and 4-2008 preclinical PETs). scanner is based on monolithic LYSO crystals coupled silicon photomultipliers. The results obtained for both protocols are compared with current commercial whole body PETs found in literature. Spatial resolution, sensitivity, NECR scatter-fraction characterized standards, as well an image quality study. A customized...
The authors have developed a small animal Positron emission tomography (PET) scanner based on monolithic LYSO crystals coupled to multi-anode photomultiplier tubes (MA-PMTs). In this study, the report design, calibration procedure, and performance evaluation of PET system that using innovative nonpixelated detector design.The is made up eight compact modules forming an octagon with axial field view (FOV) 40 mm transaxial FOV 80 diameter. order fully determine its performance, recently issued...
Hybrid molecular and anatomical imaging devices, especially when simultaneously working, have shown to provide advantages over sequential acquisitions. In particular, we present in this preliminary study, the working performance of a brain positron emission tomography (PET) insert, within 3T magnetic resonance (MRI) system. To our knowledge, is largest PET system based on monolithic LYSO blocks. It consists 60 scintillator blocks <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract In this article, we present the geometrical design and preliminary results of a high sensitivity organ-specific Positron Emission Tomography (PET) system dedicated to study human brain. The system, called 4D-PET, will allow accurate imaging brain studies due its expected sensitivity, 3D spatial resolution and, by including precise photon time flight (TOF) information, boosted signal-to-noise ratio (SNR). 4D-PET incorporates an innovative detector based on crystal slabs...
Objective: Time-of-flight positron emission tomography (PET) is the next frontier in improving effective sensitivity. To achieve superior timing for time-of-flight PET, combined with high detection efficiency and cost-effectiveness, we have studied applicability of BaF2 metascintillators driven by cross-luminescence photon production.Approach: Based on previous simulation studies energy sharing analytic multi-exponential scintillation pulse, as well sensitivity characteristics,...
In Positron Emission Tomography (PET) detectors based on monolithic scintillators, the photon interaction position needs to be estimated from light distribution (LD) photodetector pixels. Due finite size of scintillator volume, symmetry LD is truncated everywhere except for crystal center. This effect produces a poor estimation positions towards edges, an especially critical situation when linear algorithms, such as Center Gravity (CoG), are used. When all faces painted black, one in contact...
We present the calibration and performance tests carried out with two detectors for intense proton pulses accelerated by lasers. Most of procedures were realized beams 0.46-5.60 MeV from a tandem accelerator. One approach made use radiochromic films, which we calibrated relation between optical density energy deposition over more than three orders magnitude. The validity these results our analysis algorithms has been confirmed controlled irradiation film stacks reconstruction total beam...
Abstract Background Prostate cancer (PCa) represents one of the most common types cancers facing male population. Nowadays, to confirm PCa, systematic or multiparametric MRI-targeted transrectal transperineal biopsies prostate are required. However, due lack an accurate imaging technique capable precisely locate cancerous cells in prostate, ultrasound sample random parts and, therefore, it is possible miss regions where those present. In spite improvement with MRI, low reproducibility its...
Abstract Objective Positron Emission Tomography (PET) is a well-known imaging technology for the diagnosis, treatment, and monitoring of several diseases. Most PET scanners use Ring-Shaped Detector Configuration (RSDC), which helps obtain homogeneous image quality but are restricted to an invariable Field-of-View (FOV), scarce spatial resolution, low sensitivity. Alternatively, few systems Open Configurations (ODC) permit accessible FOV adaptable different target sizes, thus optimizing Yet,...
In this work we describe a procedure to reduce the number of signals detected by an array 256 Silicon Photomultipliers (SiPMs) using resistor network divide signal charge into few readout channels. Several configurations were modeled, and pulsed at contacts simulated. These simulation results experimentally tested on specifically designed manufactured set printed circuit boards. Three modeled. The modeling provided encouraging for all three configurations. measurements prototypes constructed...
In this paper, the noise of 3D computed tomography (CT) image reconstruction using QR-Decomposition is analyzed. There are several types that can interfere with interpretation an image. Here, introduced by process studied. analysis, condition numbers calculated different CT model parameters, three dimensional (3D) simulated and real data performed, analysis performed through various quality parameters number linear system related parameters. Results show number's dependence on model. Image...
We report on benchmark tests of a 3 TW/50 fs, table-top laser system specifically developed for proton acceleration with an intrinsic pump rate up to 100 Hz. In two series single-shot measurements differing in pulse energy and contrast the successful operation diode pumped is demonstrated. Protons have been accelerated 1.6 MeV interactions pulses focused aluminium mylar foils between 0.8 25 μm thickness. Their spectral distributions maximum energies are consistent former experiments under...
Fast timing in gamma-ray detectors is pivotal to enable accurate time-of-flight (TOF) Positron Emission Tomography (PET). While electronics already can reach intrinsic capabilities well below 50 ps, and photosensors also provide performances, scintillators lag behind. Herein, order achieve sufficient sensitivity, dense inorganic crystals such as LYSO or BGO with thicknesses of 10–30 mm are required. The response relatively slow, about 40 300 ns, respectively. Alternative these crystals,...