A5024429237- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Public health and occupational medicine
- Sexual Differentiation and Disorders
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Circular RNAs in diseases
- Heart Rate Variability and Autonomic Control
- MicroRNA in disease regulation
- Bone health and osteoporosis research
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects and Toxicity Studies
- Cancer-related molecular mechanisms research
- Labour Market and Migration
- RNA modifications and cancer
- Adrenal Hormones and Disorders
- Toxoplasma gondii Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Nutrition and Health Studies
Medical University of Lodz
2014-2024
Poznan University of Medical Sciences
2023
University of Southern California
2008
Abstract The anti–hepatitis C virus (HCV) effect and safety of three different oral doses the cyclophilin inhibitor Debio 025 in combination with pegylated interferon-α2a (PEG IFN-α2a) were investigated a multicenter, randomized, double-blind, placebo-controlled escalating dose-ranging phase II study treatment-naïve patients chronic hepatitis C. Doses 200, 600, 1,000 mg/day PEG IFN-α2a 180 μg/week for 4 weeks compared monotherapy either or IFN-α2a. In genotypes 1 4, 600- 1,000-mg treatments...
Virologic and safety outcomes of ombitasvir/paritaprevir/ritonavir ± dasabuvir ribavirin (OBV/PTV/r DSV RBV) therapy have shown high sustained virologic response (SVR) rates good tolerability in most patient populations pre-registration studies.To confirm these clinical trial findings the treatment genotype 1 4 hepatitis C under real-world conditions.Patients enrolled for with OBV/PTV/r RBV based on therapeutic guidelines were included, regimen was administered according to product...
INTRODUCTION: The results from 2 phase 3 studies, through years, in chronic hepatitis B infection showed tenofovir alafenamide (TAF) had similar efficacy to disoproxil fumarate (TDF) with superior renal and bone safety. We report updated 5 years. METHODS: Patients HBeAg-negative or HBeAg-positive without compensated cirrhosis were randomized (2:1) TAF 25 mg TDF 300 once daily double-blind (DB) fashion for up followed by open-label (OL) 8 Efficacy (antiviral, biochemical, serologic),...
Was to assess current prevalence of hepatitis C virus (HCV) genotypes in Poland, including their geographic distribution and changes a given period time.Data were collected with questionnaires from 29 Polish centers included data patients diagnosed HCV infection between 1 January 2013 31 March 2016.In total, 9800 reported. The highest was estimated for genotype 1b (81.7%), followed by 3 (11.3%), 4 (3.5%), 1a (3.2%) 2 (0.2%). Genotype 5 or 6 reported only (0.1%). observed central (łódzkie,...
The molecular mechanism of hepatocellular carcinoma (HCC) is related to DNA damage caused by oxidative stress products induced hepatitis B virus (HBV) or C (HCV) infection and exposure environmental pollutants. Single-nucleotide polymorphisms (SNPs) response (DDR) genes may influence individual susceptibility risk factors affect repair efficacy, which, in turn, can the HCC. study evaluates a panel 15 SNPs 11 DDR (XRCC1, XRCC3, XPD, MUTYH, LIG1, LIG3, hOGG1, PARP1, NFIL1, FEN1, APEX1) 65 HCC...
AMA Flisiak R, Pogorzelska J, Berak H, et al. Efficacy of HCV treatment in Poland at the turn interferon era – EpiTer study. Clinical and Experimental Hepatology. 2016;2(4):138-143. doi:10.5114/ceh.2016.63870. APA Flisiak, R., Pogorzelska, J., Berak, H., Horban, A., Orłowska, I., & Simon, K. (2016). Hepatology, 2(4), 138-143. https://doi.org/10.5114/ceh.2016.63870 Chicago Robert, Joanna Hanna Andrzej Iwona Krzysztof Ewelina Tuchendler 2016. "Efficacy study". Hepatology 2 (4): Harvard K.,...
Summary Background In two phase 3 studies, tenofovir alafenamide (TAF) showed non‐inferior efficacy versus disoproxil fumarate (TDF), with more favourable renal and bone safety in patients chronic hepatitis B (CHB). Aims Here, we report the studies' final 8‐year results. Methods CHB (hepatitis e antigen [HBeAg]‐negative HBeAg‐positive) were randomised (2:1) to double‐blind TAF 25 mg/day or TDF 300 for up years, followed by open‐label (OL) through year 8. Virological, biochemical, serological...
Pharmacological treatment options for nonalcoholic fatty liver disease (NAFLD) are limited. It has been suggested that thiazolidinediones may be useful in NAFLD treatment.An open-label prospective study was conducted to assess the efficacy and safety of rosiglitazone nondiabetic subjects with NAFLD.A total 27 (mean age 44 ± 11 years, body mass index 29.2 3.1 kg/m2), biopsy-confirmed no other complaints, were treated 4 mg daily 6 months.No adverse events observed during a 6-month...
Summary Background Patients with chronic hepatitis B (CHB) who switch from tenofovir disoproxil fumarate (TDF) to alafenamide (TAF) show changes in lipid profiles. Aim To evaluate how these affect cardiovascular risk. Methods This pooled analysis, based on two large prospective studies, evaluated fasting profiles of patients CHB were treated TAF 25 mg/day or TDF 300 for 96 weeks. fulfilled the American College Cardiology criteria (age 40–79 years, high‐density lipoprotein [HDL] 20–100 mg/dL,...
ARTICLE Insulin resistance and liver steatosis in type 1 diabetes the metabolic response. 1In T1DM, exogenous insulin supplementation is adjusted to a patient's requirement.Despite treatment tailored individual needs, IR might still develop T1DM.IR linked following clinical factors: increased waist -to -hip ratio (WHR), hypertension, family history of 2 INTROduCTION Type mellitus ( T1DM) an autoimmune disease characterized by destruction β cells absolute deficiency.Insulin (IR) state which...
Oxidative stress is one of the pillars crucial in development a non-alcoholic fatty liver disease (NAFLD) and may cause DNA damage. Since main pathway responsible for repair oxidative damage base-excision (BER) pathway, we examined relationship between presence different genetic variants BER-associated genes risk NAFLD. The study evaluates seven single nucleotide polymorphisms (SNPs) within five genes, hOGG1, APEX1, NEIL1, LIG3, LIG1, 150 NAFLD patients 340 healthy controls. genotyping was...
BACKGROUND The introduction of direct-acting antivirals (DAAs) has considerably improved therapeutic outcomes for patients with chronic hepatitis C virus (HCV) infections. AMBER-CEE study aimed to assess real-world efficacy and safety ombitasvir/paritaprevir/ritonavir/+ dasabuvir ±ribavirin (OBV/PTV/r/ +DSV±RBV) in the treatment post-transplant recurrence HCV infection. MATERIAL AND METHODS Liver transplant recipients recurrent genotype 1 infection, scheduled OBV/PTV/r/+DSV±RBV according...
Aim: To assess the diagnostic value of selected miRNAs from various material collected hepatocellular carcinoma (HCC) patients. Patients & methods: Tissue, serum, urine and fecal samples HCC patients healthy individuals were screened for associated using microarray analysis; then validated by real time-quantitative PCR on 65 Results: Serum miR-122, a combination serum miR-155 with miR-885-5p, urinary miR-532-3p miR-765, miR-320a displayed 100% efficiency in discriminating controls. A miR-765...
Background:Heart rhythm turbulence (HRT) is a novel tool for evaluation of cardiovascular mortality.Liver cirrhosis associated with hemodynamic and myocardial disturbances termed cirrhotic cardiomyopathy.In the stable stage liver cirrhosis, systolic dysfunction correlated brain natriuretic peptide (BNP).The aim was to evaluate HRT its correlation NT-proBNP, echocardiographic biochemical parameters in patients decompensation cirrhosis.
Behçet's disease (BD) is a multiorgan inflammatory of complex and not entirely elucidated etiology, which was originally diagnosed in patients with aphthous stomatitis, genital ulcerations ocular manifestations. The entity endemic countries Eastern Central Asia, especially Turkey Iran, but rarely seen Europe. As there are no specific diagnostic laboratory tests or histopathologic findings confirm the preliminary diagnosis, final diagnosis should be based on clinical criteria. Frequently...
Autoimmune polyglandular syndrome, type 1 (APS-1) is a rare syndrome. Here we present case report of 24-year-old female patient who complained progressive weakness. While autoimmune hepatitis was diagnosed, no improvement biochemical parameters obtained after immunosuppressive treatment. Hypoparathyroidism and adrenocortical failure were identified. Her health status clearly improved once proper control the calcium-phosphate metabolism administration substitution hydrocortisone doses,...