A5101993611- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Biosensors and Analytical Detection
- Influenza Virus Research Studies
- COVID-19 Impact on Reproduction
- Bacteriophages and microbial interactions
- Bladder and Urothelial Cancer Treatments
- Infection Control and Ventilation
- Long-Term Effects of COVID-19
- Virus-based gene therapy research
- vaccines and immunoinformatics approaches
- Zoonotic diseases and public health
- Whipple's Disease and Interleukins
- Malaria Research and Control
- Pneumonia and Respiratory Infections
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetics, Bioinformatics, and Biomedical Research
- COVID-19 diagnosis using AI
Johns Hopkins University
2022-2024
Johns Hopkins Medicine
2022-2024
University of Warwick
2021-2022
The increase in SARS-CoV-2 infections December 2021 was driven primarily by the Omicron variant, which largely displaced Delta over a three-week span. Outcomes from infection with remain uncertain. We evaluated whether clinical outcomes and viral loads differed between during period when both variants were co-circulating.
The increase in SARS-CoV-2 infections December 2021 the United States was driven primarily by Omicron variant which largely displaced Delta over a three week span. Outcomes from infection with remain uncertain. We evaluate whether clinical outcomes and viral loads differ between during period when both variants were co-circulating.
An increase in influenza like illness children and adolescents at the Johns Hopkins Health system during summer 2022 was associated with increased positivity for enterovirus/ rhinovirus. We sought to characterize epidemiology viral evolution of enterovirus D68 (EV-D68).
The rapidity with which SARS-CoV-2 XBB variants rose to predominance has been alarming. We used a large cohort of patients diagnosed Omicron infections between September 2022 and mid-February 2023 evaluate the likelihood admission or need for supplemental oxygen in infected variants. Our data showed no significant association XBB.1.5 admissions. Older age groups, lack vaccination, immunosuppression underlying heart, kidney, lung disease associations hospitalization.
The circulation and the genomic evolution of influenza A(H3N2) viruses during 2021/2022 2022/2023 seasons were studied associated with infection outcomes.
ABSTRACT Pregnant patients are at greater risk of hospitalization with severe COVID-19 than non-pregnant people. This was a retrospective observational cohort study remnant clinical specimens from who visited acute care hospitals within the Johns Hopkins Health System in Baltimore, MD–Washington DC, area between October 2020 and May 2022. Participants included confirmed respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pregnant people matched (the matching criteria age,...
ABSTRACT Respiratory disease, attributed to influenza, respiratory syncytial virus (RSV), and SARS-CoV-2, was reported nationally during the 2023/2024 viral season. The emergence of novel SARS-CoV-2 variants considered a significant factor contributing rise in COVID-19 cases. Data from Johns Hopkins Hospital System (JHHS) showed that enterovirus/rhinovirus had also been circulating at high rates. Analyzing clinical outcomes most prevalent viruses is crucial for understanding role genotypes....
The variant of concern Omicron has become the sole circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for past several months. subvariants BA.1, BA.2, BA.3, BA.4, and BA.5 evolved over time, with BA.1 causing largest wave infections globally in December 2021-January 2022. This study compared clinical outcomes patients infected different relative viral loads recovery infectious virus from upper specimens.
ABSTRACT An increase in the circulation of human adenoviruses (HAdV) 2023 was notable. HAdV genotypes circulating were characterized. Viral loads, clinical presentations, and outcomes associated with genotypes. Remnant respiratory samples positive for after standard-of-care testing at Johns Hopkins Microbiology laboratory ( N = 270) collected genotyping by next-generation sequencing hexon gene. loads assessed using droplet digital PCR. The association between predominant genotypes, outcomes,...
Influenza, a human disease caused by viruses in the Orthomyxoviridae family, is estimated to infect 5% -10 % of adults and 20% -30 children annually. Influenza A (IAV) B (IBV) accumulate amino acid substitutions (AAS) hemagglutinin (HA) neuraminidase (NA) proteins seasonally. These changes, as well dominating viral subtypes, vary depending on geographical location, which may impact prevalence severity season. Genomic surveillance crucial for capturing circulation patterns characterizing AAS...
BACKGROUND. Increased SARS-CoV-2 reinfection rates have been reported recently, with some locations basing on a second positive PCR test at least 90 days after initial infection. In this study, we used Johns Hopkins genomic surveillance data to evaluate the frequency of sequencing-validated, confirmed, and inferred reinfections between March 2020 July 2022.
Abstract Background Enterovirus D68 (EV-D68) is associated with severe respiratory disease and acute flaccid myelitis (AFM). The 2022 outbreaks showed increased viral circulation hospital admissions, but the expected rise in AFM cases did not occur. We analyzed EV-D68 genomes infection outcomes from (a year without a national increase cases) 2018 surge to understand how genomic changes might influence outcomes. Methods Residual samples that tested positive for rhinovirus/enterovirus at Johns...
Abstract Importance Pregnant women are at increased risk of severe COVID-19, but the contribution viral RNA load, presence infectious virus, and mucosal antibody responses remain understudied. Objective To evaluate association COVID-19 outcomes following confirmed infection with vaccination status, responses, virus recovery levels in pregnant compared non-pregnant women. Design A retrospective observational cohort study remnant clinical specimens from SARS-CoV-2 infected patients between...
Background: Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), presents an extra challenge in the management of patients with cancer, given increase morbidity mortality having both conditions. Cancer are well known to have a high risk VTE; particularly; those who had major surgery, chemotherapy and/or hormonal therapy. These groups need understand factors prophylactic measures prevent developing VTE. This review aims provide overview literature...
Abstract The widespread existence of expired antigen testing kits in households and potential coronavirus outbreaks necessitate evaluating the reliability these kits. Our study examined BinaxNOW COVID-19 rapid tests 27 months post-manufacture 5 past their FDA extended expiration dates, using SARS-CoV-2 variant XBB.1.5 viral stock. We conducted at two concentrations: Limit Detection (LoD) 10 times LoD. 100 unexpired were tested each concentration for a total 400 tests. At LoD (2.32x10^2...
The study examining the reliability of expired antigen testing kits in context COVID-19 has significant real-world implications. By demonstrating that these retain their sensitivity detecting virus, this work provides evidence can still be utilized, reducing waste and optimizing resources health care systems.
Increased reinfection rates with SARS-CoV-2 have recently been reported, some locations basing on a second positive PCR test at least 90 days after initial infection.We identified cases where patients had two tests for and evaluated which of these sequenced as part our surveillance efforts, sequencing clinical data.750 (920 samples) the test. The median time between was 377 days, 724 (79%) post 90-day positives were collected emergence Omicron variant in November 2021. Sequencing attempted...
Background: An increase in influenza like illness children and adolescents at the Johns Hopkins Health system during summer 2022 was associated with increased positivity for enterovirus/ rhinovirus. We sought to characterize epidemiology viral evolution of enterovirus D68 (EV-D68).Methods: A cohort remnant respiratory samples tested Microbiology Laboratory screened (EV-D68). EV-D68 positives were characterized by whole genome sequencing loads assessed droplet digital PCR (ddPCR). Genomic...