A5101642314- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Greenhouse Technology and Climate Control
- Plant responses to elevated CO2
- Regulation of Appetite and Obesity
- Traditional Chinese Medicine Studies
- Plant Water Relations and Carbon Dynamics
- Neonatal Respiratory Health Research
- Pregnancy-related medical research
- Amino Acid Enzymes and Metabolism
- Cancer-related molecular mechanisms research
- Polyamine Metabolism and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammasome and immune disorders
- Advanced Technologies and Applied Computing
- Chromium effects and bioremediation
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Drug Transport and Resistance Mechanisms
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Quality and Safety in Healthcare
- Pharmacological Receptor Mechanisms and Effects
- Dye analysis and toxicity
Guizhou University
2025
Wenzhou Medical University
2020-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2023
South Central Minzu University
2021
Hubei University of Chinese Medicine
2018-2020
Xinjiang Medical University
2016-2019
Tumor Hospital of Xinjiang Medical University
2019
First Affiliated Hospital of Xinjiang Medical University
2016
West China Hospital of Sichuan University
2012
Sichuan University
2012
Obesity is a risk factor for breast cancer in postmenopausal women. As body weight and fat mass increase, circulating leptin increases. Leptin an adipocyte-derived cytokine that acts through the long form of its receptor, termed OB-Rb. To investigate whether associated with cancer, we determined expression OB-Rb human epithelial HBL100 cells carcinoma-derived T-47D cells, influenced proliferation these evaluated structure mammary tissue genetically obese leptin-deficient Lep(ob)Lep(ob)...
Vitamin D regulates cell proliferation, inhibits cytokines release at sites of inflammation and reduces inflammatory responses. In this study, the aim was to investigate whether exogenous vitamin attenuates LPS-induced lung injury via modulating epithelial migration, apoptosis mesenchymal transition (EMT). Murine in vitro primary type II alveolar work were included study. vivo, mice mildly deficient, 0.1, 1.5, 10 mg/kg 1,25(OH)2-vitamin D3 or 25(OH)-vitamin administrated by means an...
Being overweight is a risk factor for postmenopausal breast cancer and associated with an increased incidence shortened latency of spontaneous chemically Induced mammary tumors in rodents. However, leptin-deficient obese Lep ob female mice have reduced incidences oncogene-induced tumors. Of interest, leptin enhances the proliferation human cell lines which receptors are expressed, suggests that signaling plays role tumor development. We evaluated development MMTV-TGF-α/Lepr db Lepr exhibit...
Obesity is a risk factor for postmenopausal breast cancer and associated with shortened mammary tumor (MT) latency in MMTV-TGF-alpha mice dietary-induced obesity. One link between obesity the adipokine, leptin. Here, focus on diet-induced MT fat pad (MFP) leptin apoptotic signaling proteins.MMTV-TGF-alpha were fed low-fat or high-fat diets from 10 to 85 weeks of age. High-Fat divided into Obesity-Prone Obesity-Resistant groups based final body weights. Mice followed assess development obtain...
Hyperuricemia nephropathy (HN) is a form of chronic tubulointerstitial inflammation, caused by the deposition monosodium urate crystals (MSU) in distal collecting duct and medullary interstitium, associated with secondary inflammatory reaction. Numerous published reports indicated that NLRP3 inflammasome pathway play crucial roles HN symptoms. The present study aims to investigate protective effects methyl gallate on mice underlying mechanisms. An model was established intraperitoneal...
The mitotically associated lncRNA (MANCR) participates in breast cancer cell proliferation, while its involvement other cancers is still unknown. In this study, we therefore studied the role of MANCR mantle lymphoma (MCL). We found that serum and Runt-related transcription factor 2 (RUNX2) were upregulated MCL patients when compared with those healthy controls. A positive correlation between RUNX2 was but not Upregulation distinguished from overexpression promoted expression cells, failed to...
Eosinophils exert a number of inflammatory effects through the degranulation and release intracellular mediators, are considered to be key effector cells in allergic disorders, including asthma. In order investigate regulatory natural polyphenol, resveratrol, on eosinophils derived from asthmatic individuals, cell counting Kit‑8 assay flow cytometry analysis were used determine proliferation cycle progression these cells, respectively. Cellular apoptosis was detected using annexin...
Abstract Acute respiratory distress syndrome/acute lung injury (ARDS/ALI) is histologically characterized by extensive alveolar barrier disruption and excessive fibroproliferation responses. Protectin DX (PDX) displays anti‐inflammatory potent inflammation pro‐resolving actions. We sought to investigate whether PDX attenuates LPS (lipopolysaccharide)‐induced via modulating epithelial cell repair, apoptosis fibroblasts activation. In vivo, was administered intraperitoneally (IP) with 200...
Abstract Great understanding of the genotypic difference in diurnal stomatal conductance ( g s ) pattern and key determinants is important for saving water by adopting cultivars appropriately. Fifteen wheat genotypes were studied under different soil conditions various meteorological with pot cultivation rain shelter two years. Genotype air humidity found to be pattern. All low relative (LRH) most high (HRH) displayed a gradual decline from morning through afternoon. Under moderate (MRH),...
A good understanding of the response photosynthesis rate ( P N ) and transpiration Tr to stomatal alteration during diurnal variations is important cumulative photosynthetic production water loss crops. Six wheat genotypes were studied for 2 years with pot cultivation in rain-shelter. Among different genotypes, conductance g s was significantly correlated both . But each genotype, though regardless relative air humidity (RH) status it also under lower RH (LRH, 15.4%) moderate (MRH, 28.3%),...
Herbal material is both a medicine and commodity. Accurate identification of herbal materials necessary to ensure the safety effectiveness medication. With this work, we initiated an method investigate species authenticity for products Celastrus orbiculatus Tripterygum wilfordii utilizing DNA barcoding technology. An ITS2 (internal transcribed spacer two) barcode database including 59 sequences was successfully established estimate reliability species-level Tripterygium. Our findings showed...
The antitumor activity of the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A in human breast cancer cells was investigated. Our vitro study focused on testing effects proliferation, clonogenicity, invasiveness, cell signaling and PA levels hormone-independent MDA-MB-435 cells. We also investigated action, polyamine pools tolerability administered to nude mice carrying xenografts. suppressed anchorage-independent -dependent growth invasiveness inhibition associated with...
Background Serum cystatin C ( ys‐ ), an inhibitor of cysteine proteases, has been suggested as ideal biomarker glomerular filtration rate GFR ). Objectives The objective this study was to describe the reference intervals serum and identify factors associated with or its variability, including age, gender, creatinine rea), blood urea nitrogen BUN uric acid UA Design Methods , rea, were measured in 4,517 healthy participants aged 8–89 years attending our hospital. analyzed using a...
We have previously observed that inhibition of polyamine biosynthesis with α-difluoromethylornithine (DFMO) upregulates production thrombospondin-1 (TSP-1), an extracellular matrix protein potent anti-angiogenic and antimetastatic properties, by MDA-MB-435 human breast cancer cells in culture. The present experiments were designed to investigate the mechanisms which DFMO regulates TSP-1 this system. 35S-methionine pulse chase indicated administration increased synthesis approximately 6-fold,...
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Cultivated ginseng in the farmland would become mainly planting mode of Panax ginseng. However,there are relatively few cultivation varieties for China. Correlative analysis qualitity and agronomic traits P. could provide a reference selection excellent germplasm new variety breeding In this study,the main index saponin 4-6 years' samples were analyzed by UPLC measured. The results show that there was significant difference indexes Damaya. coefficient variation root length( CV = 41....