Objective To estimate the incidence of herpes zoster (HZ) in patients with rheumatoid arthritis (RA) compared general population USA. Methods This retrospective, longitudinal cohort study used data from an administrative claims database containing both commercial and Medicare Advantage Part D data, a period October 2015 to February 2020. Patients were aged ≥ 18 years divided into 2 cohorts: RA without RA. Diagnosis procedure codes identify HZ cases calculate rates (IRs) cohorts. Data...

To quantify the economic burden of postpartum depression (PPD) that accrues to commercially insured households in year following childbirth.Administrative claims data from OptumHealth Care Solutions (2009-2016) were used identify included women identified with PPD per algorithm and propensity score-matched comparison who not or a history after childbirth. Study outcomes direct total all-cause medical pharmaceutical costs during first childbirth number outpatient visits at household level...

Abstract Context Data quantifying the impact of metreleptin therapy on survival in non-human immunodeficiency virus (HIV)-related generalized lipodystrophy (GL) and partial (PL) are unavailable. Objective This study aimed to estimate treatment effect patients with GL PL. Design/Setting/Patients Demographic clinical characteristics were used match metreleptin-treated metreleptin-naïve Differences mortality risk estimated between matched cohorts patient using Cox proportional hazard models....

Aims Provide the first national description across US of variations in healthcare measures 2018 among Medicaid beneficiaries with schizophrenia.Materials and methods Adult ≥2 diagnoses for schizophrenia, continuous enrollment consistent geographical data all were identified from Transformed Statistical Information System (T-MSIS) Analytic Files (TAF) 45 50 states. Antipsychotic (AP) utilization rates, including long-acting injectable APs (LAIs), quality metrics, all-cause resource costs...

Objectives: Pressure-Enabled Drug Delivery (PEDD), a method using pressure to advance catheter-delivered drug distribution, can improve treatment for hepatocellular carcinoma (HCC) and liver metastases, but real-world evidence is limited. We compared baseline patient characteristics, clinical complexity, post-procedure healthcare resource utilization (HRUs) complications PEDD non-PEDD procedures.

To estimate the incremental healthcare resource utilization (HRU) and cost burden posed by herpes zoster (HZ) in adult patients with rheumatoid arthritis (RA) United States.A retrospective cohort study was conducted using an administrative claims database containing commercial Medicare Advantage Part D data, between October 2015 February 2020. Patients RA HZ (RA+/HZ+) or without (RA+/HZ-) were identified based on diagnosis codes relevant medications. Outcomes measured included HRU medical,...

Aim: To evaluate treatment effects of eteplirsen among patients with Duchenne muscular dystrophy. Methods: Using real-world claims and electronic medical record data, this retrospective comparative analysis assessed eteplirsen-treated control cohorts matched by age, disease progression state, pre-index period healthcare resource utilization. Poisson regression was used to on utilization outcomes. Results: Eteplirsen associated statistically significant reductions in rates hospital encounters...

Patients with psoriasis (PsO) are at increased risk of herpes zoster (HZ), but recent data on the incidence HZ among patients PsO and impact healthcare resource use (HRU) costs for have not been described. This retrospective, longitudinal, cohort study estimated in cohorts adults vs without (PsO + PsO-) HRU those PsO, /HZ /HZ-) using Optum's de-identified Clinformatics Data Mart Database during 2015-2020. psoriatic arthritis were excluded from all four cohorts. Comparisons between used...

Objective This retrospective observational study aimed to compare healthcare resource utilization and costs of Medicare beneficiaries with chronic lymphocytic leukemia (CLL)/small lymphoma (SLL) who received ibrutinib versus chemoimmunotherapy (CIT) in first line (1 L).Methods Fee-for-service (FFS) Advantage (MA) claims data were used identify adults a CLL/SLL diagnosis initiating 1 L single agent or CIT between 4 March 2016 30 September 2017 (index date). HRU (Medicare spending) evaluated...

// David G. Proudman 1 , Deepshekhar Gupta Dave Nellesen Jay Yang 2 Beth A. Kamp Khalid Mamlouk and Bruce D. Cheson 3 Analysis Group, Inc., Menlo Park, CA 94025, USA Epizyme, Cambridge, MA 02139, Lymphoma Research Foundation, New York, NY 10005, Correspondence to: Proudman, email: david.proudman@analysisgroup.com Keywords: tazemetostat; propensity score matching; wild-type EZH2; follicular lymphoma; objective response rate Received: February 02, 2022 Accepted: April 26, Published: May 11,...

Patients with inflammatory bowel disease (IBD) are at increased risk of herpes zoster (HZ). We evaluated the incidence HZ in ulcerative colitis (UC) and Crohn's (CD) patients compared this a non-IBD population.We conducted retrospective cohort study (GSK identifier: VEO-000043) adults aged ≥18 years UC CD without IBD who were identified from claims recorded US healthcare database between October 2015 February 2020. Crude rates/1,000 person-years (PY) calculated, comparisons rates or cohorts...

To evaluate the effects of metreleptin in distinct subgroups patients with generalized lipodystrophy (GL) and partial (PL), using multivariate linear regression modeling to account for role patients' baseline usage concomitant glucose lipid-lowering medications other covariates on their outcomes.A post-hoc statistical analysis two published single-arm, interventional, phase 2 clinical trials at NIH was conducted. Concomitant medication use assessed trial population prescription fill data,...

Patients with ulcerative colitis (UC) or Crohn's disease (CD) are at increased risk of herpes zoster (HZ); however, relevant cost and healthcare resource utilization (HCRU) data limited.We estimated HCRU (hospitalization, emergency department [ED], outpatient visits) costs in patients UC CD, without HZ, using administrative claims (October 2015-February 2020). (2020 US dollars) were compared 1 month, quarter, year after the index date, propensity score adjustment generalized linear models.In...

Patients with psoriasis (PsO) and psoriatic arthritis (PsA) are at increased risk of herpes zoster (HZ), but healthcare resource use (HRU) costs relating to HZ in adults PsA unknown. We aimed estimate the incidence among vs without disease additional HRU patients HZ.

Herpes zoster (HZ) is a painful condition caused by reactivation of the varicella-zoster virus. The objectives this study were to compare HZ incidence in adults with asthma versus without and healthcare resource use as well direct costs alone USA.

INTRODUCTIONRacial disparities in prostate cancer (PC) are well studied among Black or African American (BAA) patients but not Hispanics, a quickly growing US minority group. This study compared overall survival (OS) and healthcare resource utilization (HRU) by race Medicaid-insured with metastatic castration-sensitive PC (mCSPC) castration-resistant (mCRPC).MATERIALS AND METHODSA retrospective longitudinal cohort of Medicaid claims was conducted to estimate racial OS (with multivariable Cox...

Lipodystrophy (LD) is an ultra-rare disease associated with significant morbidity and mortality. Effects of LRT on metabolic in GL PL have been studied; but effects mortality are unknown. We investigated these using data from patients treated at NIH (N=114) cared for not 3 centers the U.S. Turkey (N=178). Four abnormalities (liver, kidney, heart, HbA1c ≥6.5%) were considered. had a mean 2.8 prior to treatment, while untreated was 0.7 similar age. used matching approach create comparable...

26 Background: Racial inequalities in healthcare have long existed the United States, with Black or African American (BAA) men having higher overall cancer death rates compared to other racial ethnic groups. One of greatest disparities is prostate (PC), which disproportionately affects BAA men, though when matched for stage, whether outcomes differ by race controversial. This study assessed differences survival (OS) and resource utilization (HRU) Medicaid-insured patients metastatic...

29 Background: Prostate cancer (PC) disproportionately affects Black or African American (BAA) men in the United States (US), but racial disparities outcomes are not well understood. This study analyzed OS, healthcare resource utilization (HRU), and PC treatments Medicaid-insured metastatic castration resistant (mCRPC) patients. Methods: retrospective longitudinal cohort evaluated de-identified data from Centers for Medicare Medicaid Services 100% files 01/01/2010 – 12/31/2018. The included...