A5048218438- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Hemoglobinopathies and Related Disorders
- Substance Abuse Treatment and Outcomes
- Acne and Rosacea Treatments and Effects
- Prostate Cancer Treatment and Research
- Opioid Use Disorder Treatment
- Epilepsy research and treatment
- Urinary Tract Infections Management
- Complement system in diseases
- Multiple Myeloma Research and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Neuroblastoma Research and Treatments
- Pediatric Urology and Nephrology Studies
- Blood groups and transfusion
- Pituitary Gland Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Attention Deficit Hyperactivity Disorder
- Chronic Lymphocytic Leukemia Research
- Cannabis and Cannabinoid Research
- Advanced Breast Cancer Therapies
- Iron Metabolism and Disorders
Analysis Group (United States)
2015-2024
University of Southern California
2021
Menlo School
2018
Columbia University
2008-2013
New York State Psychiatric Institute
2008-2013
National University of Singapore
2012
Queen Elizabeth Hospital
2012
National University Hospital
2012
Queen Margaret Hospital
2012
New York State Office of Alcoholism and Substance Abuse Services
2008-2011
Abstract Background Rett syndrome (RTT) is a neurodevelopmental disorder that almost exclusively affects females and associated with high clinical burden. However, literature characterizing the real-world journey of patients RTT limited. This study provided an overview epidemiology, patient characteristics, manifestations, healthcare resource utilization (HRU), costs, treatment patterns in US. Methods IQVIA™ Medical Claims Data Longitudinal Prescription (11/01/2016–10/31/2019) were used to...
The present study investigated the efficacy of nefazodone and bupropion‐sustained release for treating cannabis dependence. A double‐blind, placebo‐controlled, piggy back design was employed to assess if increased probability abstinence from reduced severity dependence withdrawal symptoms during a 13‐week outpatient treatment program. One‐hundred six participants (Mean = 32 years; females n 25) were randomized one three medication conditions (nefazodone, release, or placebo) participated in...
The relationships between the occupational, educational, and verbal-cognitive characteristics of health care professionals their motivational interviewing (MI) skills before, during, after training were investigated.
Abstract Context Limited natural history data are available in patients with non-HIV–related lipodystrophy syndromes who never received disease-specific therapies, making interpretation of benefits therapies challenging. Objective We assessed the generalized (GL) and partial (PL) have leptin or other lipodystrophy-specific therapies. Design/Setting/Patients conducted an international chart review 230 confirmed GL PL at five treatment centers Patients were observed from birth to loss...
This retrospective observational study assessed if second-line chemotherapy vs. androgen receptor-targeted agents (ARTAs; abiraterone/enzalutamide) is associated with improved outcomes in metastatic castration-resistant prostate cancer (mCRCaP) patients who experience early progression on first-line ARTAs a US community setting.Patients mCRCaP (n = 345) progressed ≤ 12 months after ARTA and received (docetaxel/cabazitaxel; n 147) or 198) between May 2011 October 2014 were identified. Overall...
Objective To estimate the incidence of herpes zoster (HZ) in patients with rheumatoid arthritis (RA) compared general population USA. Methods This retrospective, longitudinal cohort study used data from an administrative claims database containing both commercial and Medicare Advantage Part D data, a period October 2015 to February 2020. Patients were aged ≥ 18 years divided into 2 cohorts: RA without RA. Diagnosis procedure codes identify HZ cases calculate rates (IRs) cohorts. Data...
Abstract Real-world data were collected to examine antimicrobial resistance (AMR) prevalence, treatment patterns, and clinical outcomes among female patients with uncomplicated urinary tract infection (uUTI) in Germany. Data from a retrospective physician-based chart review completed by physicians treating uUTI. Non-pregnant women aged ≥ 12 years, uUTI diagnosis, an E. coli- positive urine culture between January 2017–December 2019, susceptibility test results for 4 drug classes eligible....
To evaluate the economic burden and treatment patterns of patients with paroxysmal nocturnal hemoglobinuria (PNH) treated eculizumab, a C5 inhibitor, who were defined as blood transfusion-dependent (TD) versus transfusion-free (TF) in US population.Patients aged at least 12 years two claims for eculizumab infusion (first claim was index date) identified from IBM® MarketScan® Research Databases (April 1, 2014-September 30, 2019). The overall PNH user cohort stratified into TD (i.e., one...
The purpose of this 12-week open trial was to evaluate the potential utility atomoxetine for treatment attention deficit hyperactivity disorder (ADHD) in cocaine-dependent seekers. sample consisted 20 participants with all meeting DSM-IV-TR criteria ADHD and cocaine dependence (CD). Using several measures assess ADHD, there a significant reduction symptoms. There no decrease use throughout trial. Taken together, although individuals showed some symptoms while receiving atomoxetine, high...
Sub-optimal patient adherence to iron chelation therapy (ICT) may impact outcomes and increase cost of care. This study evaluated the economic burden ICT non-adherence in patients with sickle cell disease (SCD) or thalassemia.
Objective: To examine the change in total symptoms, and symptom clusters, of depression newly abstinent opioid-dependent individuals being treated with depot naltrexone (Depotrex; Biotek, Inc., Wellesley, MA). Method: In a series patients (N = 34) maintenance relapse prevention therapy, mood was assessed 17-item Hamilton Depression (HAM-D) Scale subscale scores at baseline, after induction 2- 4-week post-baseline. Data were analyzed using generalized estimated equation (GEE) models. Results:...
This pilot study compared basic neurocognitive functioning among older and younger cocaine abusers control participants, as a preliminary assessment of whether specific cognitive deficits exist in an aged cocaine-abusing population. We hypothesized interaction between aging abuse, such that would exhibit decreased neuropsychological test performance relative to both participants. Four groups (n = 20 each) were examined: (ages 51–70), 21–39), two nonillicit substance-using groups. Basic...
This study tested the hypothesis that antidepressant venlafaxine would be an effective treatment for cocaine abusers with concurrent depressive disorders.This was a randomized, 12-week, double-blind, placebo-controlled trial of outpatients (N = 130) meeting DSM-IIIR criteria dependence and major depression or dysthymia (by SCID interview). Participants were treated venlafaxine, up to 300 mg/day versus placebo. All patients received weekly individual manual-guided relapse prevention therapy....
Lennox–Gastaut syndrome (LGS) is a chronic and severe form of epilepsy characterized by intractable seizures, cognitive impairment, abnormal electroencephalogram findings with slow spike-wave complexes. It typically presents before age 8, but symptoms continue into adulthood require lifelong treatment associated significant clinical burden. Data on LGS-associated healthcare utilization costs are limited. In this study we use claims-based LGS classifier based random forest methodology to...
Achieving biochemical control (normalization of insulin-like growth factor-1 [IGF-1] and hormone [GH]) is a key goal in acromegaly management. However, IGF-1 GH fluctuate over time. The true potential impact time-varying status on comorbidities unclear relies multiple, longitudinal measurements. This study assessed the association between onset selected patients with acromegaly.Medical charts adults confirmed ≥ 6 months follow-up at an Italian endocrinology center were reviewed. Patients...
Abstract Background Nontransfusion‐dependent thalassemia (NTDT) refers to a diverse group of mutations and clinical phenotypes that do not require chronic transfusions. It is increasingly prevalent in the United States. Procedure This study reviews epidemiology characteristics 138 patients with NTDT treated at four US centers from 1997 2014. Data on laboratory results, transfusions, complications were collected patient charts. Results Overall, 84 α‐thalassemia (62 deletional hemoglobin H; 22...
This study assessed the clinical and economic burden of geographic atrophy (GA) using real-world data from elderly patients with Medicare Advantage plans in United States.
Antisocial personality disorder (ASPD) is highly associated with substance use disorders (SUD). In addition to the full ASPD syndrome, which requires both childhood conduct and adult features, other antisocial behavioral syndromes, including (CD) alone without syndrome CD (AABS) are also frequently diagnosed in patients SUD. The aim of this study was compare rates these various syndromes between cocaine- cannabis-dependent individuals seeking treatment. A structured interview for excluding...