Central mechanisms related to referred muscle pain and temporal summation of muscular nociceptive activity are facilitated in fibromyalgia syndrome (FMS) patients. The present study assessed the effects an NMDA-antagonist (ketamine) on these central mechanisms. FMS patients received either i.v. placebo or ketamine (0.3 mg/kg, Ketalar®) given over 30 min two separate occasions. Habitual intensity was a visual analogue scale (VAS). Initially, 29 isotonic saline determine which were responders...

Objective To evaluate the effectiveness of an Acceptance Commitment Therapy based self-help book for people with chronic pain. Method This was a randomized 2 group study design. Over 6-week period, 6 participants read and completed exercises from it weekly telephone support whereas 8 others formed wait-list control group. Subsequently, 5 intervention. Participants preintervention postintervention questionnaires acceptance, values illness, quality life, satisfaction depression, anxiety,...

The effect of a partial neuromuscular block on the ventilatory response to hypercarbia and hypoxaemia was studied in 11 non-anaesthetized male subjects. Respiratory frequency, tidal volume, minute respiratory timing drive were measured during air breathing stimulation by hypoxaemia. defined as ratio between, respectively, volume ventilation stimulated compared measurements breathing. repeated three separate occasions: before established, an infusion vecuronium aiming at mechanical adductor...

Thirty elderly patients undergoing major hip surgery under spinal analgesia were randomly allocated in a double‐blind manner into three groups. The aim was to evaluate the influence of intrathecal morphine and postoperative naloxone infusion on regulation ventilation. Bupivacaine Group received with 20 mg bupivacaine intrathecally. Morphine + 0.3 Naloxone intrathecally intravenously (1 μg/kg/h over 12 h, 0.25 next h). Evaluation resting ventilation ventilatory responses hypercarbia...

ABSTRACT Streptococcal pyogenic exotoxins (Spe proteins) secreted by Streptococcus pyogenes (group A , GAS) are responsible for scarlet fever and streptococcal toxic shock syndrome. Most Spes superantigens that cause excessive inflammation activating large numbers of T cells. However, exotoxin B (SpeB) is an exception, which pro-inflammatory through its protease activity. Prior work shows SpeB has the potential to cleave bacterial proteins. If cleavage results in their inactivation, this...

Objective Sickle cell disease (SCD) negatively impacts patients’ functioning and quality of life. Acceptance Commitment Therapy (ACT) promotes acceptance difficult sensations, emotions, thoughts when doing so facilitates living a values-based This study describes ACT for improving life an adolescent with SCD his parents. Methods A 16-year old parents attended eight-session program. Process (adolescent psychological flexibility, parent acceptance) outcome social anxiety, pain, functioning,...

Both in vitro and vivo models are employed for assessing the pandemic potential of novel emerging influenza A viruses laboratory settings, but systematic examinations how well viral titer measurements obtained align with results from experimentation not frequently performed. We show that certain following infection a human bronchial epithelial cell line positively correlated titers specimens collected virus-inoculated ferrets employ mathematical modeling to identify commonalities between...

Group A

Group A Streptococcus (GAS, pyogenes) is a professional human pathogen that commonly infects the skin. Keratinocytes are one of first cells to contact GAS, and by inducing inflammation, they can initiate earliest immune responses invasion. Here, we characterized proinflammatory cytokine repertoire produced primary keratinocytes surrogate cell lines used in vitro. Infection induces several cytokines chemokines, but constitutively secrete IL-18 form inert (pro-IL-18) lacks activity....

The influence of different oxygen flow rates on ventilation and arterial blood gases was investigated in ten healthy volunteers during treatment with the Hudson® mask. Respiratory parameters were calculated using inductive plethysmography calibrated against pneumotachography. minute greater when mask less than 5 1/min compared to no used. With an rate 3 1/min, about 140% without face 0 increased 160%. increase mainly due tidal volume. No change seen, however, Paco 2 rates. Secondary...

ABSTRACT The pro-inflammatory cytokine IL-6 regulates antimicrobial responses that are broadly crucial in the defense against infection. Our prior work shows promotes killing of M4 serotype group A Streptococcus (GAS) but does not impact globally disseminated M1T1 associated with invasive infections. Using vitro and vivo infection models, we show induces phagocyte reactive oxygen species (ROS) responsible for differential susceptibility GAS to IL-6-mediated defenses. Clinical isolates...

Sixty-seven nonrandomized patients undergoing major hip surgery performed under spinal analgesia with bupivacaine and morphine (0.3 mg) were studied. The aims to find a suitable dose regimen of naloxone that offered protection against respiratory depression without altering pain relief, measure plasma levels for comparison the clinical effects observed. most beneficial was found be 1 μg/kg/hr given during first 12 hours postoperatively 0.25 next hours. In higher doses (1-5 μg/kg/hr), relief...

The increasing frequency of antibiotic resistance poses myriad challenges to modern medicine. Environmental survival multidrug-resistant bacteria in health care facilities, including hospitals, creates reservoirs for transmission these difficult treat pathogens. To prevent bacterial colonization, facilities deploy an array infection control measures, bactericidal metals on surfaces, as well implanted devices. Although antibiotics are routinely used environments, it is unknown whether and how...

The ventilatory performance of four portable emergency ventilators (Logic 07, Motivus Oxylog and Pneupac II) was tested on a lung model. model consisted one common (tracheal) tube, two separate (bronchial) tubes in which different obstructions could be applied, glass jars filled with water to suitable compliances. Dialled volume compared measured volume. gas distribution produced by the also studied. It found that alt lour distribute lungs. Logic 07 had acceptable relationships between...

The first recognized case in Scandinavia with potential man to transmission of viral haemorrhagic fever occurred Linköping, Sweden, January 1990. Following a visit Kenya 21-year-old male student suffered very severe illness including extremely prolonged high grade fever, rash, disseminated intravascular coagulation thrombocytopenia and bleedings. This necessitated one month intensive care support respirator treatment. patient was discharged after 2 1/2 months good condition, partial femoral...

A method for clinical studies of the ventilatory response to carbon dioxide and hypoxaemia in patients is described. The main parameters with this are respiratory frequency, tidal volume, minute timing, drive. ventilation volunteers was not affected while breathing air through designed apparatus. reproducible similar what has previously been Our proved suitable test responses varying degrees impaired ventilation‐perfusion ratios thus also a low Pao 2 . higher accuracy than earlier methods.

Prognostic factors and treatment results were analysed in 72 consecutive patients with primary gastric lymphoma treated between 1970 1985. There 37 stage IE, 17 IIE, 3 IIES 15 IV. Histopathological re-evaluation classification according to the TNM system performed. We found that disseminated disease (stage IV), serosal penetration (T3), involvement of adjacent organs (T4) extensive abdominal lymph node (N3) poor prognostic factors. Neither histological malignancy grading, nor appearance...

Two cases of ventilator tubing mishaps, resulting from defective heat and moisture exchangers, are described. The report emphasises the need for preoperative inspection anaesthetic machine associated equipment as well importance a disconnect alarm device.