A5091372502- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- CRISPR and Genetic Engineering
- Plant tissue culture and regeneration
- Insect Resistance and Genetics
- Plant Virus Research Studies
- Transgenic Plants and Applications
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Coconut Research and Applications
- Peanut Plant Research Studies
- Tuberous Sclerosis Complex Research
- Research in Cotton Cultivation
- Legume Nitrogen Fixing Symbiosis
- PI3K/AKT/mTOR signaling in cancer
- Plant Disease Resistance and Genetics
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Organ Donation and Transplantation
- Nematode management and characterization studies
- Weed Control and Herbicide Applications
- Pluripotent Stem Cells Research
- Plant nutrient uptake and metabolism
- Genetic Syndromes and Imprinting
- Microbial Community Ecology and Physiology
Texas Tech University
2024-2025
Texas A&M University
2017-2022
Sanford Research
2019-2022
Indian Institute of Oilseeds Research
2017
Osmania University
2017
Introduction Plant roots, nematodes, and soil microorganisms have a complex interaction in the rhizosphere by exchanging or communicating through biomolecules chemicals signals. Some rhizospheric (including endophytic) microbes process such compounds via biogeochemical cycles to improve fertility, promote plant growth development, impart stress tolerance plants. can affect negatively on parasitic nematodes (PPNs) thus hindering ability of parasitizing roots. Next-generation sequencing is one...
In seeds and other parts of cultivated, tetraploid cotton (Gossypium hirsutum L.), multicellular groups cells lysigenously form dark glands containing toxic terpenoids such as gossypol that defend the plant against pests pathogens. Using RNA-seq analysis embryos from near-isogenic glanded (Gl2 Gl2 Gl3 ) versus glandless (gl2 gl2 gl3 plants, we identified 33 genes expressed exclusively or at higher levels in just prior to gland formation plants. Virus-induced gene silencing three pairs led...
Significance An increasing number of herbicide-resistant weeds are being reported in the United States, Argentina, and Brazil. This is becoming a global challenge for production several major crops, such as cotton, maize, soybean. New strategies weed control required to sustain agricultural while reducing our dependence on herbicides. Here, we report that selective fertilization transgenic expressing bacterial phosphite dehydrogenase (PTXD), with provides an effective way suppress growth....
Despite the high quality of soybean protein, raw soybeans and meal cannot be directly included into animal feed mixtures due to presence Kunitz (KTi) Bowman Birk protease inhibitors (BBi) which reduces performance. Heat treatment can substantially inactivate trypsin chymotrypsin but such is energy intensive, adds expense, negatively impact seed proteins. As an alternative approach we have employed CRISPR/Cas9 gene editing create mutations in BBi genes drastically lower inhibitor content...
Despite the high quality of soybean protein, raw soybeans and meal cannot be directly included in animal feed mixtures due to presence Kunitz (KTi) Bowman-Birk protease inhibitors (BBis), which reduces productivity. Heat treatment can substantially inactivate trypsin chymotrypsin but such is energy-intensive, adds expense, negatively impacts seed proteins. As an alternative approach, we have employed CRISPR/Cas9 gene editing create mutations
Alagille syndrome patients present with loss of function mutations in either JAG1 or NOTCH2. About 40%-50% have kidney abnormalities, and frequently display multicystic, dysplastic kidneys. Additionally, gain-of-function NOTCH2 are associated cystic kidneys Hajdu-Cheney patients. How perturbations Notch signaling cause renal tubular cysts remains unclear. Here, we determined that reduced mediated transcription by ectopic expression dominant-negative mastermind-like (dnMaml) peptide the...
Abstract The plasticity and diversity of cell types with specialized functions likely defines the capacity multicellular organisms to adapt physiologic stressors. kidney collecting ducts contribute water, electrolyte, pH homeostasis are composed mature intermingled epithelial that susceptible transdifferentiate. conversion duct principal cells intercalated is actively inhibited by Notch signaling ensure urine concentrating capability. Here we identify Hes1, a target signaling, allows for...
Abstract Alagille syndrome patients present with loss of function mutations in either JAG1 or NOTCH2 . About 40-50% have kidney abnormalities, multi-cystic, dysplastic kidneys being one the more frequent defects. Additionally, gain-of-function are associated cystic Hajdu-Cheney patients. Conditional inactivation Notch1, Notch2 , RBPJ within nephrogenic lineage impairs nephrogenesis and produces proximal tubule cysts mice. How perturbations Notch signaling cause renal tubular remains unclear....
Abstract The distal nephron and collecting duct segments of the mammalian kidney consist intercalated cell types intermingled among principal types. Notch signaling ensures that a sufficient number cells select instead an fate. However, precise mechanisms by which patterns fates is unknown. Here we observed Hes1 , direct target pathway, required within mouse developing ducts for repression Foxi1 expression, essential specific transcription factor. Interestingly, inactivation in -deficient...