A5065211820- Renal Diseases and Glomerulopathies
- Genetic Neurodegenerative Diseases
- Probabilistic and Robust Engineering Design
- Proteoglycans and glycosaminoglycans research
- Model Reduction and Neural Networks
- Amyotrophic Lateral Sclerosis Research
- Hedgehog Signaling Pathway Studies
- Control Systems and Identification
- Nerve injury and regeneration
- Advanced MRI Techniques and Applications
- Complement system in diseases
- Neurological disorders and treatments
- MRI in cancer diagnosis
- Vasculitis and related conditions
- Renal and Vascular Pathologies
- Parkinson's Disease Mechanisms and Treatments
- Pediatric Urology and Nephrology Studies
- Fibroblast Growth Factor Research
- Cerebrovascular and genetic disorders
- Cellular Mechanics and Interactions
- Thyroid and Parathyroid Surgery
- Child Abuse and Related Trauma
- Drug Transport and Resistance Mechanisms
- Ultrasound Imaging and Elastography
- Metabolism and Genetic Disorders
Teikyo University
1987-2025
Creative Commons
2022
Saiseikai Ibaraki Hospital
2021
Jichi Medical University
2015-2018
Jichi Medical University Saitama Medical Center
2015-2016
Bioscience (China)
2015
Nagoya University
1996-2011
National Defense Medical College
2002
In patients with aromatic l-amino acid decarboxylase (AADC) deficiency, a decrease in catecholamines and serotonin levels the brain leads to developmental delay movement disorders. The beneficial effects of gene therapy from 1 8 years age homogeneous severity disease have been reported Taiwan. We conducted an open-label phase 1/2 study population including adolescent different degrees severity. Six were enrolled: four males (ages 4, 10, 15 19 years) one female (age 12 severe phenotype who...
Glycosaminoglycans (GAGs), large anionic glycopolymers, are the glycan portion of proteoglycans and important components extracellular matrix. Recently we reported that polysialic acid, a polyanionic glycopolymer specific to brain, binds neurotrophic factors form complex. It is not clear whether GAGs also bind In present study, demonstrate brain-derived factor (BDNF) dimer directly other than chondroitin hyaluronic acid Neurotrophin-3 showed similar GAG binding properties. Furthermore, BDNF,...
Polysialic acid (polySia) is a linear polymer of sialic that modifies neural cell adhesion molecule (NCAM) in the vertebrate brain. PolySia large and exclusive functions as negative regulator cell–cell interactions. Recently, we demonstrated polySia can specifically bind fibroblast growth factor 2 (FGF2) BDNF; however, protective effects on proteolytic cleavage these proteins remain unknown, although heparin/heparan sulfate has been shown to impair FGF2 by trypsin. Here, analyzed...
Freezing of gait (FOG) is a common disorder in Parkinson’s disease (PD) and could be attributed to reduction brain noradrenaline. The aim this study was determine the relationship between aromatic L -amino acid decarboxylase (AADC) activity locus coeruleus (LC) FOG PD using high-resolution positron emission tomography with an AADC tracer, 6-[ 18 F]fluoro- - m -tyrosine (FMT). We assessed 40 patients 11 age-matched healthy individuals. diagnosed based on UK Brain Bank criteria by two movement...
Abstract Aromatic l-amino acid decarboxylase (AADC) is an essential dopamine-synthesizing enzyme. In children with AADC deficiency, the gene delivery of into putamen, which functionally interacts cortical regions, was found to improve motor function and ameliorate dystonia. However, how restoration dopamine in putamen association cortico-putaminal networks leads therapeutic effects remains unclear. Here, we examined neuroimaging data eight patients deficiency (five males three females, age...
Bioelectrical impedance analysis (BIA) is a commonly used noninvasive technique for body composition assessment with recently expanded indications. This reproducible measurement method uses electrical conductivity to evaluate composition, including fluid status. In pediatric idiopathic nephrotic syndrome (INS), albumin leaks into the urine, resulting in dysregulated colloid-osmotic pressure blood vessels. results decreased circulating volume and edema. Blood tests are useful evaluation...
Neuropeptide Y (NPY) has at least three receptors (Y1, Y2, and Y3) through which it influences different mechanisms in many cell types. Previous data suggest that the Y2 receptor may be divided into prejunctional postjunctional subgroups. We have examined intracellular signalling pathways of rat renal proximal tubules. The results indicate NPY regulates Na+,K(+)-ATPase several pathways: (1) In tubule (PT) cells increased calcium. response was blocked by removing extracellular calcium also...
Model order reduction is an important tool in control systems theory. In particular, it useful for controller design since the dimension of becomes very high when we use advanced Balanced truncation one most model methods. But general stability feedback system not maintained reduced by balanced truncation. This paper proposes a novel method which can preserve system. A numerical example demonstrates effectiveness proposed method.
Despite the usefulness of blood oxygenation level-dependent (BOLD) MRI in assessing glomerulonephritis activity, its relationship with histological findings remains unclear. Because presents multiple complex injury patterns, analysis each pattern is essential. We aimed to elucidate between kidney and BOLD mesangial proliferative glomerulonephritis.
Real-time ultrasound-guided percutaneous kidney biopsy is essential for diagnosis and treatment planning; nonetheless, the optimal puncture approach has yet to be established. In vivo, performing different approaches on same patient at once not possible. This study aimed determine impact of number obtained glomeruli their potential cause arterial injury using pig kidneys, which are similar humans.A total 120 kidneys (60 right-sided 60 left-sided kidneys) research were from a slaughterhouse....
The authors declare no conflict of interest.
In this paper, we propose a finite-dimensional approximation for nonlinear infinite-dimensional system via balanced realization. The proposed method is accomplished by realization and singular value analysis systems. This approach expected to derive effective approximate models preserving particular input-output behavior. Necessary sufficient conditions characterizing systems are derived. Furthermore, the effectiveness of shown numerical simulation.
In this paper, we propose a finite-dimensional approximation for nonlinear infinite-dimensional system via balanced realization.The proposed method is accomplished by realization and singular value analysis systems.This approach expected to derive effective approximate models preserving particular input-output behavior.To obtain systems, sufficient condition necessary one characterizing them are derived.Finally, the effectiveness of shown numerical simulation.
Stabilizing blood levels with microemulsified cyclosporine A (CsA), administered in many pediatric kidney diseases, is important for effective immunosuppression and reduced nephrotoxicity. CsA affected by total bile acids (TBAs); however, no reports have simultaneously measured both. We aimed to elucidate the hypothesized relationship between TBA diurnal variation children.We retrospectively reviewed medical records of children who were taking oral treatment diseases January 2016 July 2021....