A5048764213- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Williams Syndrome Research
- RNA regulation and disease
- Oral microbiology and periodontitis research
- Crystallography and Radiation Phenomena
- Asymmetric Synthesis and Catalysis
- Glycosylation and Glycoproteins Research
- Amino Acid Enzymes and Metabolism
- Nuclear Materials and Properties
- Liquid Crystal Research Advancements
- Immune Response and Inflammation
- Photochemistry and Electron Transfer Studies
- Fusion materials and technologies
- Nuclear materials and radiation effects
- Peripheral Neuropathies and Disorders
- Epilepsy research and treatment
- Optical Imaging and Spectroscopy Techniques
- Syphilis Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Esophageal Cancer Research and Treatment
Jichi Medical University
2015-2024
Nagasaki Medical Center
2024
Jichi Medical University Hospital
2018-2022
Nagasaki University
2016-2022
Nagasaki Rousai Hospital
2020
Ehime University
2019-2020
Weill Cornell Medicine
2019
Cornell University
2019
Shanghai Institute for Science of Science
2018
Institute of Science and Technology
2018
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of Unimolecular Micelles Random Copolymers Sodium 2-(Acrylamido)-2-methylpropanesulfonate and Methacrylamides Bearing Bulky Hydrophobic SubstituentsYotaro Morishima, Shigeki Nomura, Takahiro Ikeda, Michiko Seki, Mikiharu KamachiCite this: Macromolecules 1995, 28, 8, 2874–2881Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April...
In patients with aromatic l-amino acid decarboxylase (AADC) deficiency, a decrease in catecholamines and serotonin levels the brain leads to developmental delay movement disorders. The beneficial effects of gene therapy from 1 8 years age homogeneous severity disease have been reported Taiwan. We conducted an open-label phase 1/2 study population including adolescent different degrees severity. Six were enrolled: four males (ages 4, 10, 15 19 years) one female (age 12 severe phenotype who...
While a growing body of neurocognitive research has explored the neural substrates associated with attention deficit hyperactive disorder (ADHD), an objective biomarker for diagnosis not been established. The advent functional near-infrared spectroscopy (fNIRS), which is noninvasive and unrestrictive method neuroimaging, raised possibility introducing neuroimaging in young ADHD children. Previously, our fNIRS-based measurements successfully visualized hypoactivation pattern right prefrontal...
A convenient pathway for controlling defect-free nanoscopic domains over large areas is illustrated. simple rubbing technique used to align nanocylinders self-assembled in an amphiphilic diblock liquid-crystalline copolymer by introducing novel supramolecular cooperative motions between mesogens and microphase domains. 3D macroscopic array of the a area achieved parallel direction (see figure inside cover).
The pathogenicity of oral bacteria was studied by measuring the development subcutaneous abscesses in mice after infection with Actinomyces viscosus and Streptococcus mitis either singly or as co-aggregated pairs. Heat-treated cells were also tested. co-aggregates examined various viable heat-treated combinations two bacterial species. More formed A. than S. at all concentrations Also, abscess formation strains produced a higher percentage those caused pure suspensions mitis. Co-aggregated...
Sensors based on surface plasmons or waveguide modes are at the focus of interest for applications in biological environmental chemistry. Waveguide-mode spectra 1 mum-thick pure and perforated silica films comprising isolated nanometric holes with great aspect ratio were measured before after adhesion streptavidin concentrations 500 nM. The shift angular position guided was nine times higher than bulk films. Capturing nanoholes is origin that largely enhanced as amplitude mode perfectly...
The structurally damaged zone in titanium dioxide rutile single crystal induced by MeV-order heavy ions was observed using high resolution electronic microscopy (HREM). Stressed regions as well amorphous were identified the areas. Both stressed and etched with hydrofluoric acid. thermal spike model used to calculate track radii variation versus electron stopping power. When calculated lattice temperature did not exceed melting point of (2130K), no structural change introduced ions, such...
Approximately 80% of cases mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) harbor a heteroplasmic m.3243A>G transition in the tRNALeu (UUR) (MTTL1) gene. We report MELAS case with rare m.3243A>T mutation found by direct sequencing MTTL1. This has been previously reported 5 cases, which 2 had phenotype. Our also strengthens hypothesis that can cause
Connectivity between brain regions has been redefined beyond a stationary state. Even when person is in resting state, connectivity dynamically shifts. However, shifted under externally evoked stimulus still little understood. The current study, therefore, focuses on task-based dynamic functional-connectivity (FC) analysis of signals measured by functional near-infrared spectroscopy (fNIRS). We hypothesize that may influence not only but also the occurrence probabilities task-related and...
Attention deficit/hyperactivity disorder (ADHD) has been frequently reported as co-occurring with autism spectrum (ASD). However, ASD-comorbid ADHD is difficult to diagnose since clinically significant symptoms are similar in both disorders. Therefore, we propose a classification method of differentially recognizing the condition children. The was investigated based on functional brain imaging measured by near-infrared spectroscopy (NIRS) during go/no-go task. Optimization and...
Abstract Aromatic l-amino acid decarboxylase (AADC) is an essential dopamine-synthesizing enzyme. In children with AADC deficiency, the gene delivery of into putamen, which functionally interacts cortical regions, was found to improve motor function and ameliorate dystonia. However, how restoration dopamine in putamen association cortico-putaminal networks leads therapeutic effects remains unclear. Here, we examined neuroimaging data eight patients deficiency (five males three females, age...
A 10-year-old Japanese boy developed acute hepatitis with high levels of serum Torque teno virus DNA and marked lymphocytopenia, especially CD4+ T-lymphocytopenia. Although the total lymphocyte counts rose as patient recovered from hepatitis, this was largely because a rise in CD8+ cells. In contrast, cells poorly, resulting further striking fall CD4/8 ratio. Two months later, hepatitis-associated aplastic anemia. He successfully treated immunosuppressive therapy, which normalized subset...
Applying a tritium tracer technique, we have investigated hydrogen plasma driven permeation (PDP) through tungsten (W) near room temperature. The technique was confirmed to give reliable data on diffusion and coefficients of pure W for gas (GDP), then it applied observe PDP in It found that earlier phase controlled by giving coefficients. Taking literature at higher temperatures present ones temperature determined from into account, proposed new coefficientsDUpper limit = (3.8±0.4)x10-7 exp...
Coffin–Siris syndrome is a rare congenital malformation and intellectual disability syndrome. Mutations in at least seven genes have been identified. Here, we performed copy number analysis 37 patients with features of CSS whom no causative mutations were identified by exome sequencing. We patient 9p24.3–p22.2 duplication another the chromosome der(6)t(6;9)(p25;p21)mat. Both share duplicated 15.8‐Mb region containing 46 protein coding genes, including SMARCA2 . Dominant negative effects may...
Monochromatic x-ray emission is predicted for MeV channeled electrons/positrons. The mechanism of this radiation intuitively understood as diffraction virtual channeling into the direction Bragg angles with respect to electron beam. Our numerical calculations predict that spectral density emitted x rays about ten times larger than parametric radiation.
Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and worse prognosis for PC patients. Recently, we showed in men that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by macrophages surrounding dead or dying adipocytes forming crown-like structures, was PC. Possibly, interventions suppress WAT inflammation will improve outcomes Here, tested the hypothesis supplemental 17β-estradiol (E2) could decrease obese male mice....