A5055113673- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Phytochemistry and Bioactive Compounds
- Reproductive Biology and Fertility
- RNA Research and Splicing
- Fungal Biology and Applications
- Cancer-related gene regulation
- Sperm and Testicular Function
- Phytochemicals and Antioxidant Activities
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Hormonal and reproductive studies
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune Bullous Skin Diseases
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Nutrition, Genetics, and Disease
- DNA Repair Mechanisms
Zabol University of Medical Sciences
2018-2024
Emami (India)
2023
Shahid Beheshti University of Medical Sciences
2020-2023
Ahvaz Jundishapur University of Medical Sciences
2023
Tehran University of Medical Sciences
2023
Tarbiat Modares University
2019
Zahedan University of Medical Sciences
2015-2016
Aberrant Wnt signaling cascade is a hallmark of the triple-negative breast cancer (TNBC) that linked with increased proliferation, invasion, and poor overall survival. many genes are post-transcriptionally regulated by microRNAs (miRNAs) therefore; it indisputable dysregulation miRNAs an explanation for aberrant cascades. Thus, present study was conducted to find putative miRNA targeting key players Wnt/β -catenin in TNBC.The miR-130a-3p found as potential regulator applying several...
The Notch-regulated ankyrin repeat protein (NRARP) functions as a molecular link between Notch and Wnt signaling pathways. Although it has recently been identified to be overexpressed in breast cancer (BC), the mechanisms that regulate NRARP remain unknown. Since microRNAs (miRNAs) gene expression post-transcriptionally, miRNA dysregulation could explain abnormal expression. Here, we miR-130a-3p an regulator evaluated its effects on behavior of BC cells. Quantitative real-time PCR was...
Abstract Preclinical Research The aim of this study was to elucidate the antioxidant effects Caralluma tuberculata (C. tuberculata) in streptozotocin (STZ)‐induced diabetic rats. Diabetes induced male Wistar rats with an intraperitoneal injection STZ at dose 60 mg/kg body weight. Three days after diabetes induction, powdered aerial part plant doses 100 and 200 weight were gavaged orally for a period 45 days. significantly decreased activities superoxide dismutase, catalase, glutathione...
Sirtuins (SIRT) have recently been identified as the pivotal regulators of lifespan and health. SIRT1 has protective effects against cardiovascular disease (CVD) through its deacetylase activity it regulates numerous essential pathways including regulating blood pressure, reducing atherosclerosis, heart protection oxidative stress inducing cardiac cell survival growth. Therefore, this study was conducted to evaluate whether two genetic polymorphisms rs3758391 T/C rs369274325 G/T are...
Background FTO gene is associated with obesity, dietary intake, and the risk of colorectal cancer (CRC). In this study, patients were assessed for interactions between polymorphisms intake. Methods This case–control study was carried out on 450 participants aged 35–70 years including 150 300 healthy controls. Blood samples collected in order to extract DNA genotyping rs9939609 polymorphism. A validated 168-item food frequency questionnaire (FFQ) Nutritionist-IV software used assess Results...
Abstract Objective: Caralluma tuberculata is a succulent plant that grows in some regions of Baluchestan province Iran, and widely used by natives as antidiabetic agent. This study evaluates the effects aerial part suspension (SCT) at two doses 100 200 mg/kg its safety on liver kidneys Streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was rendered via single dose STZ (60 mg/kg, injected intraperitoneally). Forty eight rats were classified into 6 groups follow; (I): Normal...
AbstractAberrant activation of Wnt pathway is linked to dysregulation several genes. DACT1 and DACT2 are members the DACT family that participate in antagonizing signaling cascade. Thus this study, we assessed mRNA levels DACT1, DACT2, CYCLIN D1 70 pairs CRC tissues compared adjacent tissues. Determination was done by Quantitative Real-Time PCR (qRT-PCR). The correlation between genes also examined. Receiver operating characteristic (ROC) curves plotted assess diagnostic power. association...
: Systemic Lupus Erythematosus (SLE) is a chronic human autoimmune disease, which characterized by increased activity of B cells and production antibodies against tissue antigens. It engages many tissues organs, including joints, kidneys, heart, the nervous system. Although exact pathogenesis SLE remains to be elucidated, it suggested that genetic background plays paramount role in etiology. Increasing evidence indicating an important for interleukins progression SLE. Interleukins are group...
Background: Medicinal plants are considered as a useful source of antioxidants against diseases due to reducing free radicals. Caralluma tuberculata is one such sources utilized by Iranian population traditional herbal medicine. Objectives: The present study aimed at investigating antioxidant activity, total phenolic content (TPC), and flavonoid (TFC) C. root hydroalcoholic extract (CRE) aerial parts (CAE). Methods: Antioxidant properties were assessed using DPPH (1,1-dipheny l,2-picryl...
Abstract Background: Aberrant activation of Wnt pathway is linked to dysregulation several genes. DACT1 and DACT2 are members the DACT family that participate in antagonizing signaling cascade. Thus this study we assess mRNA levels , Cyclin D1 CRC tissues compared adjacent tissues. Methods: Determination was done by Quantitative Real-Time PCR (qRT-PCR). The correlation between genes examined. Receiver operating characteristic (ROC) curves plotted diagnostic power. association...
Abstract Objectives : The Notch-regulated ankyrin repeat protein ( NRARP ) functions as a molecular link between Notch and Wnt signaling pathways. Although it has recently been identified to be overexpressed in breast cancer (BC), the mechanisms regulating remain unknown. Since microRNAs (miRNAs) regulate gene expression post-transcriptionally, miRNA dysregulation could explain abnormal expression. Here, we miR-130a-3p an regulator evaluated its effects on behavior of BC cells. Methods...
Introduction: Breast cancer (BC) is a highly heterogeneous disease that has been classified into several subtypes at the molecular level, each with distinct outcome. Recently, Notch-regulated ankyrin-repeat protein (NRARP), gene expressed followed by Notch signal activation, attracted interest due to its aberrant expression in different types of cancer. Accordingly, this study evaluated levels NRARP BC. Methods: The MCF-7, SKBR3, MDA-MB-468, and MDA-MB-231 human BC cell lines, which...