Abstract Introduction The left ventricular (LV) systolic function can affect diastolic relaxation. interaction of and myocardial resembles the mechanism "coil compression relaxation." This concept has gained significant attention in recent years, challenging notion "isolated dysfunction." Speckle tracking echocardiography (STE) is a sensitive innovative method for evaluating global beyond LVEF. study examined possible correlation between longitudinal strain (GLS) different LV filling...

Salivary changes in hemodialysis patients may result various oral manifestations. This research intended to determine manifestations and some salivary markers patients.This cross-sectional study was conducted on 30 (the patient group) healthy individuals control group). Saliva urea calcium levels pH values of the participants were measured, such as pale mucosa, xerostomia, halitosis, sense taste, increased calculus formation, gingival bleeding, etc. recorded information collection form. The...

The aim of the present study was to evaluate effects occupational exposure lead (Pb) and cadmium (Cd) on markers oxidative stress in glazers tile industries. Total antioxidant capacity (TAC), malondialdehyde (MDA), activity enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) were determined blood 80 subjects, including 40 nonexposed subjects. Mean levels Cd (8.90 ± 2.80 µg/L) Pb (62.90 38.10 showed a significant increase compared with control group. In serum...

Nitric oxide (NO) is synthesized from l-arginine by endothelium nitric synthase (NOS3) and plays important roles in many physiologic pathologic processes. NO involved the pathogenesis of coronary atherosclerosis. In present study we hypothesized that polymorphisms NOS gene might be associated with increased risk artery disease (CAD) plasma concentrations. The eNOS polymorphism was investigated 241 unrelated CAD patients positive angiograms 261 ages matched control subjects without a history...

HLA-G is critically important for successful implantation during pregnancy. Increasing evidence supposed that plays a key role in tolerance of the semi-allogeneic graft pregnancy by inhibiting cytotoxic functions T and NK cells. The present study aimed to evaluate impact rs1063320 (+3142G>C) 14-bp insertion (ins)/deletion (del) polymorphisms on recurrent spontaneous abortion (RSA). Genomic DNA from 93 RSA patients normal fertile women was isolated using salting out method. Genotyping...

Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelial synthase (NOS3). Since reduced NO synthesis in cells has been implicated the development of coronary atherosclerosis, we investigated association NOS3 gene polymorphisms and artery disease (CAD) an Iranian population.We studied Glu298Asp polymorphism 241 CAD patients with positive angiograms (i.e.,> 50% stenosis affecting at least one vessel) Shahid Rajaee Heart Hospital 261 control subjects without a history...

Preclinical Research The aim of the present study was to evaluate effects thyroid dysfunction on markers oxidative stress in rat pancreas. Hypothyroidism and hyperthyroidism were, respectively, induced rats via administration propylthiouracil (PTU) L-thyroxine sodium salt drinking water for 45 days. activities superoxide dismutase (SOD), catalase (CAT), glutathioen peroxidase (GPx), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), xanthine oxidase (XO), nonenzymatic...

Abstract Preclinical Research The aim of this study was to elucidate the antioxidant effects Caralluma tuberculata (C. tuberculata) in streptozotocin (STZ)‐induced diabetic rats. Diabetes induced male Wistar rats with an intraperitoneal injection STZ at dose 60 mg/kg body weight. Three days after diabetes induction, powdered aerial part plant doses 100 and 200 weight were gavaged orally for a period 45 days. significantly decreased activities superoxide dismutase, catalase, glutathione...

Sirtuins (SIRT) have recently been identified as the pivotal regulators of lifespan and health. SIRT1 has protective effects against cardiovascular disease (CVD) through its deacetylase activity it regulates numerous essential pathways including regulating blood pressure, reducing atherosclerosis, heart protection oxidative stress inducing cardiac cell survival growth. Therefore, this study was conducted to evaluate whether two genetic polymorphisms rs3758391 T/C rs369274325 G/T are...

BACKGROUND AND OBJECTIVES:Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelial synthase (NOS3). Since reduced NO synthesis in cells has been implicated the development of coronary atherosclerosis, we investigated association NOS3 gene polymorphisms and artery disease (CAD) an Iranian population.SUBJECTS METHODS:We studied Glu298Asp polymorphism 241 CAD patients with positive angiograms (i.e., >50% stenosis affecting at least one vessel) Shahid Rajaee Heart Hospital...

Human cutaneous infection caused by a homogeneous group of keratinophilic fungi called dermatophytes. These are the most common infectious agents in humans that free any population and geographic area. Microsporum canis is cause dermatophytosis (Tinea) recent years Iran atypical strain has been isolated Iran. Its cases occur sporadically due to M. transmission from puppies cats humans. Since this pathogenic dermatophyte eukaryotes, chemical treatment with antifungal drugs may also affect...

The protein of Niemann-pick type C1 (NPC1) gene promotes the egress cholesterol from late endosomes and lysosomes to other cellular compartments contributes a process known as reverse transport. This study aimed examine whether promoter methylation NPC1 is associated with risk cardiovascular disease (CVD).Fifty CVD patients 50 healthy subjects control group were recruited in this study. Promoter was defined using nested-methylation specific polymerase chain reaction method. Statistical...

Background: In the printing industry, workers are occupationally exposed to an extensive variety of chemical solvents, including toluene and xylene. Biological monitoring is essential tool for assessing occupational health risk. Objectives: The aim present study was evaluate exposure xylene, as well biomarkers exposure, in industry. Methods: hippuric acid (HA) o-, m- p-methyl acids (o-, m-, p- MHAs) each three xylene isomers, respectively, were determined urine samples 84 subjects, 44 40...