Interleukin-1 (IL-1) is one of the pro-inflammatory cytokines that plays a main role in regulation immune and inflammatory responses. Interleukin 4 (IL-4) as an anti-inflammatory cytokine regulates balance between Th1 Th2 this study was undertaken to investigate IL-1β IL-4 genes polymorphisms patients with systemic lupus erythematosus (SLE) also association susceptibility SLE.One hundred sixty three SLE 180 healthy controls were genotyped for VNTR (variable number tandem repeat), C-511T...

Preeclampsia (PE) is a pregnancy-specific disorder that results in maternal mortality and morbidity. Growing evidence indicated cytokines are involved the pathogenesis of PE interleukin-4 VNTR polymorphism could be implicated altering risk. The aim this study was to evaluate possible association between IL-4 susceptibility Iranian population for first time. Genetic evaluated 192 186 healthy control women by polymerase chain reaction method. We found gene has significantly increased risk...

Oxidative stress plays a key role in the pathogenesis of male infertility. But, adverse effects oxidative biomarkers on sperm quality remain unclear. This study aimed to investigate levels nitric oxide (NO), 8-hydroxydesoxyguanosine (8-OHdG), and total antioxidant capacity (TAC) seminal plasma their relationship with parameters.A 77 volunteers participated study, including fertile (n=40) infertile men (n=37). NO, 8-OHdG, TAC were measured using ferric reducing ability plasma, Griess reagent...

DNA repair is reduced in patients suffering from systemic lupus erythematosus (SLE), and it can induce the production of autoreactive antibodies due to accumulation damage nucleoprotein that produce immunogenic antigens. The accumulations anti-Ku DNA-PKcs antibodies, which are involved nonhomologous end joining pathway, have been detected SLE patients. present study was designed evaluate association XRCC5, XRCC6, XRCC7 polymorphisms with susceptibility. Polymerase chain reaction (PCR)...

Evidences are suggesting that DNA damage is implicated in development of systemic lupus erythematosus (SLE). Therefore we focused on two common XRCC1 polymorphisms (Arg399Gln and Arg194Trp) SLE susceptibility South East Iran.Peripheral blood was extracted from 163 patients 180 healthy controls. PCR-restriction fragment length polymorphism method used for genotyping Arg399Gln Arg194Trp polymorphisms.The frequency Arg/Gln genotype the significantly lower than Moreover, found with malar rash...

Abstract Colorectal cancer (CRC) is a global public health problem. Despite the major milestone in early diagnosis and treatment of colorectal cancer, prevalence CRC rates still rising. The etiology unknown but we know influenced by both environment genetic factors. In this study, aimed to elucidate role vitamin D receptor gene polymorphic regions; FokI TaqI single nucleotide polymorphisms, increasing risk Birjand population. One hundred patients with 100 healthy controls recruited study....

Preeclampsia (PE) is one of the most important complications pregnancy that associated with significant mortality and morbidity in mother fetus. Since etiologic factors its development are still unclear, we aimed to examine intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism preeclamptic control healthy women. Genetic was analyzed 192 PE 186 PCR-RFLP method used identify polymorphism. The frequency KK, KE, EE genotypes ICAM-1 not different between patients pregnant Whereas, KE...

Mitochondria play a crucial role in energy metabolism for the survival and motility of sperm during fertilization. The aim this study was to determine association large-scale mitochondrial DNA deletions with abnormal morphology asthenoteratozoospermic patients.In case-control study, 41 semen samples were collected from 18 normozoospermic healthy men 23 patients, according WHO guidelines. swim-up technique used separation spermatozoa on basis their motility. Long-range polymerase chain...

Abstract Background: Recurrent pregnancy loss (RPL) is a heterogeneous condition consisting of two or more consecutive abortions occurring before 20 weeks gestation. One the clotting factor genes encodes XIII ( FXIII ), which involved in fibrin formation. The most common polymorphism conversion G to T exon 2 (val34leu) FXIIIA gene, leads substitution valine with leucine. objective this study was investigate association between RPL and val34leu polymorphisms sample population Iranian Azeri...

Breast cancer (BC) is one of the most common types and second leading cause death among women. Epidemiological studies showed that BC linked to genetic environmental factors, inheritance plays a key role in pathobiology this disease. Interleukin 4 (IL-4) differentiation cytokine produced by Th2 activates development. Hence current study aimed assess possible association between interleukin VNTR polymorphism, susceptibility sample Iranian population.IL-4 polymorphism was evaluated 150 women...

Breast cancer is one of the leading causes mortality. Growing evidence indicates that interleukins and its polymorphisms are involved in pathogenesis breast cancer. Variable number tandem repeat (VNTR) polymorphism can affect transcription rate, mRNA stability also resulting protein expression activity. Hence, present study aimed to assess possible association between interleukin-1 receptor antagonist (IL-1Ra) VNTR polymorphism, susceptibility Iranian population. A total 300 individuals, 150...

Pre-eclampsia (PE) is an obstetric disorder that may result in maternal and neonatal mortality morbidity. Growing evidence indicates cytokines, such as interleukins, are involved the pathogenesis of this complication. Hence current study aimed to assess possible association between interleukin-1 receptor antagonist (IL-1Ra) VNTR polymorphism, PE susceptibility southeast Iranian women.The IL-Ra polymorphism was evaluated 192 women 186 age-matched normotensive pregnant by polymerase chain...

Background: Uterine Leiomyoma (UL) is the most common gynecological tumor and a public health problem. Higher serum interleukin 4 (IL-4) level, as an anti-inflammatory cytokine that regulates TH1/TH2 cells balance, has been observed in uterine cavity. Objectives: The aim of this study was to investigate association between IL4 gene variable number tandem repeats (VNTR) polymorphism risk UL southeast Iran. Patients Methods: We compared 99 patients with 102 healthy controls. VNTR genotyped by...

Abstract Soluble guanylate cyclase (sGC) encompasses α and β subunits. This study examined the expression of α1, α2, β1, β2 subunits in malignant benign breast tumors using Western blot analysis. Both showed a significantly higher α1 subunit comparison with normal tissues ( p < 0.0001). In contrast, α2 sGC were lower these than .0015 .001, .007 .0001, respectively). The level was correlated ER + PR+ .0001). A significant correlation also detected for sGC‐α1 ‐α2 c‐erbB2‐negative status...

Doxorubicin (DOX) is a common chemotherapeutic agent, with toxic side effects, and chemoresistance. Combination chemotherapy successful approach to overcome these limitations. Here, we investigated the effects of pioglitazone (PGZ), PPARγ agonist, and/or DOX on viability, cell cycle, apoptosis THP-1 cells normal human monocytes (NHMs).MTT assay was used evaluate cytotoxicity PGZ. Cell cycle progression induction were examined by PI or Annexin V-PI double staining, analyzed flow cytometry....