A5042675029- Organ Transplantation Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Organ Donation and Transplantation
- Renal and related cancers
- Renal Transplantation Outcomes and Treatments
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- Ovarian cancer diagnosis and treatment
- Anesthesia and Sedative Agents
- Liver Disease and Transplantation
- Veterinary Pharmacology and Anesthesia
- Renal cell carcinoma treatment
- Electrospun Nanofibers in Biomedical Applications
- Cardiac, Anesthesia and Surgical Outcomes
Aarhus University Hospital
2019-2022
Aarhus University
2019-2021
Regional Hospital Holstebro
2016
St. Josef-Hospital
2003
Normothermic machine perfusion (NMP) of injured kidneys offers the opportunity for interventions to metabolically active organs prior transplantation. Mesenchymal stromal cells (MSCs) can exert regenerative and anti-inflammatory effects in ischemia-reperfusion injury. The aims this study were evaluate safety feasibility MSC treatment during NMP using a porcine autotransplantation model, examine potential treatment-associated kidney improvements up 14 days posttransplant. After 75 min warm...
The regenerative capacities of mesenchymal stromal cells (MSCs) make them suitable for renal therapy. most common delivery route MSC is through intravenous infusion, which associated with off-target distribution. Renal intra-arterial offers a targeted therapy, but limited knowledge available regarding the fate MSCs delivered this route. Therefore, we studied efficiency and tissue distribution after to porcine ischemia-reperfusion model. were isolated from adipose healthy male pigs,...
The immunomodulatory and regenerative properties of mesenchymal stromal cells (MSCs) make MSC therapy a promising therapeutic strategy in kidney disease. A targeted administration via the renal artery offers an efficient delivery method with limited spillover to other organs. Although local alleviates safety issues MSCs systemic circulation, it introduces new concerns kidneys. In porcine model, we employed intra-renal arterial infusion ten million allogenic adipose tissue-derived MSCs. order...
Mesenchymal stromal cell (MSC) therapy may improve renal function after ischemia-reperfusion injury in transplantation. Ex vivo intraarterial administration is a targeted delivery method, avoiding the lung vasculature, known barrier for cellular therapies. In randomized and blinded study, we tested feasibility effectiveness of MSC donation circulatory death autotransplantation model to posttransplant kidney function, using an ex method similar clinical standard procedure pretransplant cold...
This pilot study aimed to maintain acceptable animal welfare in the development of a porcine autotransplantation model with severe and incremental renal ischemic injury, for usage future intervention studies. Secondary aims were develop test methods collect blood urine without need restrain or use sedative avoid transportation optimize pig.Kidneys from 7 female pigs subjected durations warm ischemia (WI) 30, 45, 75 minutes by left artery vein clamping. After static cold storage,...
In an era where global kidney shortage has pushed the field of transplantation towards using more marginal donors, modified preservation techniques are currently being reviewed. Some require further optimization before implementation in full scale studies. Using a porcine donation after circulatory death model, we investigated whether initial hemodynamics improved during normothermic machine perfusion if this was preceded by short period oxygenated hypothermic (oxHMP) rather than static cold...
Abstract Normothermic machine perfusion (NMP) after initial hypothermic preservation of donor kidneys prior to transplantation is becoming a clinical reality, but the precise molecular mechanisms through which graft impacted remain only partially characterised. Using an unbiased proteomic methodology, we found that auto chaemically injured porcine resulted in activation stress response 14 days transplantation, as well selective changes proteins responsible for metabolism organic acids. The...
A 62-year-old woman with a history of curatively treated mucinous ovarian cancer, presented dyspnea, anorexia and right-upper-quadrant pain at consultation her general practitioner. CT scan revealed several lymph node metastases in lungs abdomen as well tumor Morrison’s pouch biopsy renal cell carcinoma. Therefore, she was referred to Department Urology. The multidisciplinary team could not immediately reject that there be an exophytic the right kidney but discrepancy between histology...