A5013462750- Cardiac Imaging and Diagnostics
- Muscle metabolism and nutrition
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac electrophysiology and arrhythmias
- Mobile Health and mHealth Applications
- Viral Infections and Immunology Research
- Physical Activity and Health
- Muscle Physiology and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Skin Diseases and Diabetes
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Obstructive Sleep Apnea Research
- Cardiac pacing and defibrillation studies
- Genetics and Physical Performance
- Inflammatory Myopathies and Dermatomyositis
- Dermatological and Skeletal Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Infectious Diseases and Tuberculosis
- Global Public Health Policies and Epidemiology
- Metabolism and Genetic Disorders
Royal Prince Alfred Hospital
2014-2024
The University of Sydney
2017-2024
The Heart Research Institute
2020
Christ University
2020
Florida Department of Health in Orange County
2014
University of Oxford
2007-2013
National Institutes of Health
2013
Centre for Human Genetics
2013
British Heart Foundation
2013
National Heart Lung and Blood Institute
2013
Creatine is thought to be involved in the spatial and temporal buffering of ATP energetic organs such as heart skeletal muscle. depletion affects force generation during maximal stimulation, while reduced levels myocardial creatine are a hallmark failing heart, leading widely held view that important at high workloads under conditions pathological stress.We therefore hypothesised consequences creatine-deficiency mice would impaired running capacity, exacerbation failure following...
Abstract Background Desmoplakin (DSP) cardiomyopathy is a rare genetic condition characterized by repeated inflammatory myocardial injury and associated with ventricular arrhythmia sudden cardiac death. Diagnosis challenging requires combination of testing advanced imaging techniques. Case summary We present the case 38-year-old woman recurrent episodes subclinical myocarditis. Investigation using magnetic resonance (cMRI) revealed diagnosis DSP cardiomyopathy. Her disease was initially...
The creatine kinase (CK) energy transport and buffering system supports cardiac function at times of high demand is impaired in the failing heart. Mice deficient muscle- mitochondrial-CK (M/Mt-CK−/−) have previously been described, but exhibit an unexpectedly mild phenotype compensated left ventricular (LV) hypertrophy. We hypothesised that heart failure would develop with age performed echocardiography LV haemodynamics 1 year. Since all previous studies utilised mice a mixed genetic...
Creatine plays an important role in energy metabolism the heart. Cardiomyocytes accumulate creatine via a specific transporter (CrT), capacity of which is reduced failing heart, resulting lower myocardial concentration. Therefore, to gain insight into how CrT regulated, we studied two mouse models severely altered levels. Cardiac uptake levels were measured isolated hearts from creatine-free guanidinoacetate-N-methyl transferase knock out (GAMT(-/-)) mice and overexpressing (CrT-OE) using...
Abstract Aims Sleep apnoea and congestive heart failure (CHF) commonly co‐exist, but their interaction is unclear. Metabolomics may clarify relationships to outcome. Methods results We assayed 372 circulating metabolites lipids in 1919 1524 participants of the Framingham Heart Study (FHS) (mean age 54 ± 10 years, 53% women) Women's Health Initiative (WHI) 67 7 years), respectively. used linear Cox regression relate plasma concentrations echocardiographic parameters; CHF its subtypes with...
We present a 16-year-old male state-level athlete (index case II:1, Figure 1A) who was struck on the left side of his chest
IMPORTANCE: The evidence that maintaining a healthy body weight in conjunction with healthier eating patterns, exercise training, and reduced stress can improve clinical outcomes patients atherosclerotic cardiovascular disease is substantial. However, little known about the magnitude temporal effects of comprehensive lifestyle treatment on coronary artery anatomy, myocardial inflammation, fibrosis people affected by heart disease. OBJECTIVE: To conduct randomised trial to determine impact...
Achieving the weekly physical activity recommendations of at least 150-300 minutes moderate-intensity or 75-150 vigorous-intensity aerobic exercise is important for reducing cardiometabolic risk, but evidence shows that most people struggle to meet these goals, particularly in mid long term.The Messages Improving Resting Heart Health (MIRTH) study aims determine if (1) sending daily motivational messages through a research app effective improving motivation and promoting adherence men women...
<sec> <title>BACKGROUND</title> Achieving the weekly physical activity recommendations of at least 150-300 minutes moderate-intensity or 75-150 vigorous-intensity aerobic exercise is important for reducing cardiometabolic risk, but evidence shows that most people struggle to meet these goals, particularly in mid long term. </sec> <title>OBJECTIVE</title> The Messages Improving Resting Heart Health (MIRTH) study aims determine if (1) sending daily motivational messages through a research app...
Creatine plays an important role in energy metabolism the heart. Cardiomyocytes accumulate creatine via a specific transporter (CrT), capacity of which is reduced failing heart, resulting lower myocardial concentration. To gain insight into how CrT regulated by intra- and extracellular concentrations, we studied two mouse models severely altered levels, guanidinoacetate-N-methyl transferase knock out (GAMT−/−) mice overexpressing (CrT-OE). We measured cardiac uptake level isolated free...