A5012170576- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Conducting polymers and applications
- Biosensors and Analytical Detection
- Extracellular vesicles in disease
- MXene and MAX Phase Materials
- Analytical Chemistry and Sensors
- Advanced Memory and Neural Computing
- Nanopore and Nanochannel Transport Studies
- Advanced Chemical Sensor Technologies
- Molecular Junctions and Nanostructures
Chongqing University
2018-2024
Chongqing University of Technology
2022-2023
In this work, a novel ratio electrochemical biosensing platform based on catalytic hairpin assembly target recovery to trigger dual-signal output was developed for ultrasensitive detection of microRNA (miRNA). To achieve the ratiometric strategy, methylene blue (MB), an indicator, ingeniously loaded into pores graphene aerogel (GA) and metal-organic framework (MOF) composites with high porosity large specific surface area, another indicator Fe-MOFs distinct separation redox potential...
Illustration of the fabrication NiCo-MOF/GO and its application in glucose determination.
Heavy metal ion (HMI) pollution is a serious threat to human health and the ecosystem. Therefore, there an urgent need develop fast sensitive platform for heavy detection. In this work, novel sensing based on ZIF-67-derived cobalt/nitrogen-doped carbon (NC) composite polyhedrons linked with multiwalled nanotubes (MWCNTs), termed Co@NC/MWCNT, simultaneous monitoring of Cd2+ Pb2+ was established. detail, nanoporous ZIF-67 first in situ grown MWCNTs, followed by carbonization, endowing good...
Herein, nanoflower-shaped Mn-doped NiO nano-enzyme composites with high catalytic performance and excellent conductivity were grown on 3D flexible carbon fiber cloth (CFC) via hydrothermal calcination methods to construct an efficient glucose-sensitive detection electrode. For electrochemical-based sensors, is a prerequisite for reliable data acquisition. To avoid the problems associated using insulating Nafion or paraffin binders, we adopted strategy of directly growing onto electrode...
Flexible electrochemical biosensors have ignited great interest because they possess the potential to provide continuous and real-time physiological information via dynamic noninvasive measurements of biochemical markers in biofluids. In this work, a cerium metal–organic framework (Ce-UiO-66- 4,4-biphenyl dicarboxylic acid (BPDC)) was first grown situ on flexible carbon fiber cloth (CFC) by one-step hydrothermal method. To further shorten response time biosensor, we used controllable growth...
Abstract Small extracellular vesicle–derived microRNAs (sEV-miRNAs) have emerged as promising noninvasive biomarkers for early cancer diagnosis. Herein, we developed a molecular probe based on three-dimensional (3D) multiarmed DNA tetrahedral jumpers (mDNA-Js)-assisted DNAzyme activated by Na + , combined with disposable paper-based electrode modified Zr-MOF–rGO–Au NP nanocomplex (ZrGA) to fabricate novel biosensor sEV-miRNAs Assay. Zr-MOF tightly wrapped rGO was prepared via one-step...
Abstract Despite numerous efforts, the accurate determination of trace biomolecules with zeptomolar sensitivity remains elusive. Here, a 3D carbon nanomaze (CAM) electrode for ultrasensitive detection such as nucleic acids, proteins, and extracellular vesicles is reported. The CAM consists an interlaced fiber array on which intercrossed graphene sheets are vertically tethered in situ, permitting local confinement molecules to increase molecular hybridization efficiency. Furthermore,...
Herein, a gold nanoparticles/graphene aerogels (AuNPs/GAs) modified electrochemical biosensor with catalytic hairpin assembly (CHA) and Y-shaped DNA nanostructure dual-signal amplification approaches for ultrasensitive microRNA-21 (miR-21) detection was successfully constructed, which displayed an ultra-wide linear range from 5 fM to 50 nM, as well relatively low limit (LOD) of 14.70 aM (S/N = 3). Furthermore, the sensing strategy had excellent specificity among highly homologous miRNA...
Abstract Real‐time quantitative monitoring of miRNAs plays an essential role in diagnosis and therapeutics. Herein, a DSN‐coupled graphene nanoarray/gold nanoparticles (GNAs/AuNPs) carbon paper (CP) electrode for the dynamic, sensitive, real‐time analysis is reported. GNAs are vertically grown on conductive CP by radio frequency plasma enhanced chemical vapor deposition, AuNPs electrodeposited CP/GNAs to build 3D ultrasensitive sensing interface with large specific surface area, good...