A5057221198- Human-Animal Interaction Studies
- T-cell and B-cell Immunology
- Neuroendocrine regulation and behavior
- Epigenetics and DNA Methylation
- Complement system in diseases
- Platelet Disorders and Treatments
- Genomic variations and chromosomal abnormalities
- Immune Cell Function and Interaction
- Adrenal Hormones and Disorders
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- MicroRNA in disease regulation
- Biomarkers in Disease Mechanisms
- Colorectal Cancer Treatments and Studies
- Exercise and Physiological Responses
- Immunodeficiency and Autoimmune Disorders
- Phagocytosis and Immune Regulation
- Adrenal and Paraganglionic Tumors
- Evolutionary Psychology and Human Behavior
- Inflammation biomarkers and pathways
- BRCA gene mutations in cancer
- Infant Health and Development
- Neuroscience of respiration and sleep
- Genetic Associations and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
Semmelweis University
2012-2025
Institute of Biochemistry
2020-2025
Eötvös Loránd University
2015-2022
Hungarian Academy of Sciences
2010-2017
Abstract The physiological roles of the factor H (FH)-related proteins are controversial and poorly understood. Based on genetic studies, FH-related protein 5 (CFHR5) is implicated in glomerular diseases, such as atypical hemolytic uremic syndrome, dense deposit disease, CFHR5 nephropathy. was also identified immune deposits at level. For CFHR5, weak complement regulatory activity competition for C3b binding with plasma inhibitor FH have been reported, but its function remains elusive. In...
The bond dogs develop with their owner received increased attention in the last years but no study aimed at characterizing way which owners interact daily life and how this might influence dog behavior. In order to examine dogs, we first analyzed behavior of 220 8 different standardized situations involving owner-dog dyad. We extracted 3 behavioral factors related "Owner Warmth", Social Support" Control". Further, investigated whether personality, gender age are associated these three...
Abstract Factor H–related protein (FHR) 1 is one of the five human FHRs that share sequence and structural homology with alternative pathway complement inhibitor FH. Genetic studies on disease associations functional analyses indicate FHR-1 enhances activation by competitive inhibition FH binding to some surfaces immune proteins. We have recently shown binds pentraxin 3. In this study, our aim was investigate whether another pentraxin, C-reactive (CRP), analyze relevance interaction, study...
Aggressive manifestations and their consequences are a major issue of mankind, highlighting the need for understanding contributory factors. Still, aggression-related genetic analyses have so far mainly been conducted on small population subsets such as individuals suffering from certain psychiatric disorder or narrow-range age cohort, but no data general is yet available. In present study, our aim was to identify polymorphisms in genes affecting neurobiological processes that might explain...
Background: ZDHHC19—a protein acyltransferase—is known to be induced in sepsis, a dysregulated immune response infection, but the underlying molecular mechanisms remain elusive. In this study, we aimed explore whether upregulation of ZDHHC19 is modulated by single nucleotide polymorphisms (SNPs) affecting binding microRNA 3’ untranslated region gene. Methods: Inpatients with clinically verified severe infection (n = 83) or sepsis 63) were recruited study. Genomic DNA and total RNA prepared...
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic at glomerular basement membrane Bruch’s is implicated in renal eye diseases, respectively. Binding soluble inhibitors ECM, including factor H (FH), important prevent excessive activation. Since FH-related (FHR) proteins FHR1 FHR5 are also these our aim was study whether FHRs can bind ECM components affect FH activity Both showed variable binding...
Oxytocin is a key modulator of emotional processing and social cognitive function. In line with this, polymorphisms genes involved in oxytocin signaling, like the receptor (OXTR) gene, are known to influence behavior various species. However, date, no study has investigated environmental factors possibly influencing epigenetic variation OXTR gene its behavioral effects dogs. Pet dogs form individualized strong relationships their owners who central figures environment therefore might...
Oxytocin receptor ( OXTR ) acts as a key behavioral modulator of the central nervous system, affecting social behavior, stress, affiliation and cognitive functions. Variants Oxtr gene are known to influence behavior both in animals humans; however, canine polymorphisms less characterized terms possible relevance function, selection criteria breeding domestication. In this report, we provide detailed characterization common variants gene. particular (1) novel were identified by direct...
Summary Several studies suggest that infection by Epstein–Barr virus (EBV) might be one of the environmental factors which facilitates development autoimmune disorders in genetically susceptible individuals. Recent data indicate high anti-Epstein–Barr nuclear antigen 1 (EBNA)-1 immunoglobulin (Ig)G titre is a strong risk factor for multiple sclerosis (MS) patients both with and without main genetic predisposing trait, human leucocyte (HLA)-DRB1*15:01. Because no similar have been published...
The RCCX region is a complex, multiallelic, tandem copy number variation (CNV). Two complete genes, complement component 4 (C4) and steroid 21-hydroxylase (CYP21A2, formerly CYP21B), reside in its variable region. prone to nonallelic homologous recombination (NAHR) such as unequal crossover, generating duplications deletions of modules, gene conversion. A series allele-specific long-range polymerase chain reaction coupled the whole-gene sequencing CYP21A2 was developed for molecular...
Summary Objective According to our previous findings, carriers of the C4B*Q0 genotype, which means zero or one copy C4B gene, is located in RCCX number variation region on chromosome 6, have a significantly shorter life‐expectancy and higher risk cardiovascular disease than non‐carriers. We postulated that genotype linked variant(s) neighboring CYP21A2 gene encoding steroid 21‐hydroxylase with altered function. Design Single‐center, observational, retrospective study. Patients Seventy‐six...
The XXIIIrd World Congress of Psychiatric Genetics meeting, sponsored by the International Society Genetics, was held in Toronto, ON, Canada, on 16-20 October 2015. Approximately 700 participants attended to discuss latest state-of-the-art findings this rapidly advancing and evolving field. following report written trainee travel awardees. Each assigned one session as a rapporteur. This manuscript represents highlights topics that were covered plenary sessions, symposia, oral sessions during...
Plasma levels of glial cell line-derived neurotrophic factor (GDNF), a pivotal regulator differentiation and survival dopaminergic neurons, are reportedly decreased in schizophrenia. To explore the involvement GDNF pathogenesis disease, case–control association analysis was performed between five non-coding single nucleotide polymorphisms (SNP) across gene Of them, ‘G’ allele rs11111 SNP located 3′ untranslated region (3′-UTR) found to associate with In silico revealed that might create...
Background: Type 2 diabetes (T2DM) and colorectal cancer (CRC) are both known to modulate gene expression patterns in peripheral blood leukocytes (PBLs). Objective : As T2DM has been shown increase the incidence of CRC, we were prompted check whether affects mRNA signatures PBLs isolated from CRC patients. Methods Twenty-two patients recruited study classified into four cohorts (healthy controls; T2DM; CRC; T2DM). Relative levels 573 cell signaling transcripts determined by reverse...
Several lines of epidemiological and biochemical evidence support the association type 2 diabetes mellitus (T2DM) colorectal cancer (CRC). T2DM has been shown to impinge on transcriptome colon tumor cells, promoting their proliferation invasion. In order gain insight into diabetes-specific modulation signaling, we analyzed gene expression patterns more than five hundred genes encoding signaling proteins TaqMan OpenArray panels from colonoscopic samples diabetic non-diabetic patients. total,...
COVID-19 associated coagulopathy (CAC), characterized by endothelial dysfunction and hypercoagulability, evokes pulmonary immunothrombosis in advanced cases. Elevated von Willebrand factor (vWF) levels reduced activities of the ADAMTS13 protease are common CAC. Here, we aimed to determine whether genetic variants these proteins might be with severity hemostatic parameters. A set single nucleotide polymorphisms (SNPs) vWF (rs216311, rs216321, rs1063856, rs1800378, rs1800383) genes (rs2301612,...
Sepsis is a dysregulated immune response to infections that frequently precipitates multiple organ dysfunction and death despite intensive supportive therapy. The aim of the present study was identify sepsis-induced alterations in signaling transcriptome peripheral blood leukocytes might shed light on elusive transition from proinflammatory anti-inflammatory responses underlie long-term post-sepsis immunosuppression. Peripheral were collected subjects (i) with systemic inflammation, (ii)...