A5048502103- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Genetic factors in colorectal cancer
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Telomeres, Telomerase, and Senescence
- Genomics and Chromatin Dynamics
- Cancer therapeutics and mechanisms
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- RNA and protein synthesis mechanisms
- Cancer, Lipids, and Metabolism
- Multiple Myeloma Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Chromatin Remodeling and Cancer
- Cancer Cells and Metastasis
Kyungpook National University
2014-2023
Matrix Research (United States)
2022
Kyungpook National University Hospital
2021
Seoul National University
2021
Yong-in Songdam College
2021
Olive View-UCLA Medical Center
2020
Abstract This study was conducted to investigate whether polymorphisms of genes involved in immune checkpoints can predict the clinical outcomes patients with advanced stage non-small cell lung cancer (NSCLC) after 1st line paclitaxel-cisplatin chemotherapy. A total 379 NSCLC were enrolled. Twelve single nucleotide (SNPs) PD-1, PD-L1 , and CTLA-4 selected genotyped. The associations SNPs chemotherapy response overall survival (OS) analyzed. Among 12 investigated, rs2297136T > C rs4143815C...
Abstract This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis patients non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide (SNPs) 17 glycolytic pathway were investigated a total 782 NSCLC who underwent curative The association SNPs overall survival (OS) and disease free (DFS) analyzed. Among 44 investigated, four ( ENO1 rs2274971A > G, PFKM rs11168417C T, PFKP rs1132173C PDK2...
Background/Aims: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts 17 Caucasians on a Korean population. Methods: Ninety-four healthy individuals were enrolled this study. Relative chromosomes from peripheral blood samples measured using quantitative polymerase chain reaction. Results: Two polymorphisms, rs10936599 MYNN rs412658 ZNF676, found...
Short telomeres are known as one of the risk factors for human cancers.The present study was conducted to evaluate association between 6 polymorphisms, which were related with short telomere length in Korean population, and lung cancer using 1,100 cases 1,096 controls.Among TERT rs2853669 significantly associated increased under a recessive model (odds ratio [OR] = 1.38, 95% confidence interval [CI] 1.05-1.81,P 0.02).The effect on significant younger individuals (OR 1.73, CI 1.18-2.54,P...
// Shin Yup Lee 1, 2, * , Mi Jeong Hong 3, 10, Hyo-Sung Jeon 3 Yi Young Choi Jin Eun 4 Hyo-Gyoung Kang Deuk Kju Jung 10 Chengcheng Sook Kyung Do Seung Soo Yoo 2 Yangki Seok 5 Eung Bae Min 6 Ji Yun 7 Won Kee 8 Jaehee 1 Ick Cha Chang Ho Kim Tae 9 Sanghoon Jheon Jae Yong Park 4, Department of Internal Medicine, School Kyungpook National University, Daegu, Republic Korea Lung Cancer Center, University Medical Biochemistry and Cell Biology, Matrix Research Institute, Thoracic Surgery, Radiology,...
Abstract Background Neurogenic differentiation factor 1 (NEUROD1) is frequently overexpressed in small‐cell lung cancer (SCLC). NEUROD1 plays an important role promoting malignant behavior and survival. Methods In this study, we evaluated the association between putative functional polymorphisms 45 target genes chemotherapy response survival outcomes 261 patients with SCLC. Among 100 single nucleotide (SNPs) studied, two were significantly associated both overall (OS) of Results The SNP...
Regulome DB is a new tool that can predict the regulatory function of genetic variants. We applied in selecting putative functional variants and evaluated relationship between these survival outcomes surgically resected non‐small‐cell lung cancer. Among 244 studied, 14 were associated with overall ( P < 0.05) discovery cohort one variant (rs2257609 C>T) was replicated validation cohort. In combined analysis, rs2257609 C>T significantly worse disease‐free under dominant model = 2 ×...
Background Genome‐wide association studies have indicated that most of the currently identified disease and trait‐associated single nucleotide polymorphisms (SNPs) are intronic or intergenic. RegulomeDB is a recently developed database provides functional annotations for regulatory features SNPs located in non‐coding regions. We evaluated potential EGFR gene region using their associations with prognosis after surgery non‐small cell lung cancer (NSCLC) patients. Methods A total 698 patients...
This study was conducted to investigate the association between variants in mitotic checkpoint-related genes and clinical outcomes of non-small cell lung cancer (NSCLC). A total 766 patients with NSCLC who underwent curative surgery were enrolled. Among 73 evaluated, 4 related survival outcomes. BUB3 rs7897156C>T associated worse overall under a recessive model (adjusted hazard ratio = 1.58, 95% confidence interval 1.07-2.33, P 0.02). AURKB rs1059476G>A better 0.64, 0.41-0.99, 0.05). PTTG1...
Achaete-scute homolog 1 (ASCL1) is a basic helix-loop-helix transcription factor and essential in the differentiation of neuroendocrine cells neural tissues. ASCL1 frequently overexpressed small cell lung cancer (SCLC) plays crucial role pathogenesis SCLC.This study was conducted to identify association between single nucleotide polymorphisms (SNPs) target genes clinical outcomes patients with SCLC after chemotherapy. A total 261 diagnosed were enrolled this study. The 103 SNPs 58 response...
This study was conducted to investigate the associations between polymorphisms of genes involved in LKB1 pathway and prognosis patients with non‐small cell lung cancer (NSCLC) after surgical resection. Twenty‐three single nucleotide (SNPs) were investigated 782 NSCLC who underwent curative surgery. The association SNPs overall survival (OS) disease‐free (DFS) analyzed. Among 23 investigated, TSC2 rs30259G > A associated significantly worse OS DFS (adjusted hazard ratio for 1.88, 95%...
This study was conducted to investigate whether polymorphisms in glycolysis-related genes are associated with clinical outcomes of patients advanced-stage non-small cell lung cancer (NSCLC) undergoing chemotherapy.A total 377 NSCLC were enrolled. Sixty-five single-nucleotide 26 involved the glycolytic pathway evaluated. The associations variants chemotherapy response and overall survival (OS) analyzed.Among 65 investigated, PFKL rs2073436C>G GPI rs7248411C>G significantly correlated after...
Abstract This study was conducted to investigate the relationship between genetic variants in LKB1/AMPK/mTOR pathway and treatment outcomes of patients with non‐small cell lung cancer (NSCLC) treated chemotherapy. A total 379 NSCLC who underwent first‐line paclitaxel‐cisplatin chemotherapy enrolled. The associations 19 single nucleotide (SNVs) response overall survival (OS) were analyzed. Among SNVs analyzed, AKT1 rs2494750G>C TSC1 rs2809244C>A associated clinical after multivariate...
<b><i>Background:</i></b> This study was conducted to investigate the association between genetic variants in one-carbon metabolism and survival outcomes of surgically resected non-small cell lung cancer (NSCLC). <b><i>Methods:</i></b> We genotyped 41 potentially functional 19 key genes pathway among 750 NSCLC patients who underwent curative surgery. The overall (OS)/disease-free (DFS) were analyzed....
Abstract We investigated the association between genetic variants in histone modification regions and prognosis of lung adenocarcinoma after curative surgery. Potentially functional SNPs were selected using integrated analysis ChIP-seq RNA-seq. The analyzed a discovery set (n = 166) validation 238). associations with overall survival (OS) disease-free (DFS) analyzed. A total 279 for genotyping. Among these, CAPN1 rs17583C>T was significantly associated better OS DFS ( P 0.001 0.007,...
Background/Aims Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate between 11 female never smokers male smokers. Methods included 714 patients 626 healthy controls. The were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay. Results Two smokers, as Male carrying rs4975616 variant allele had a significantly decreased (in codominant model: odds ratio, 0.77;...
Abstract Background Necroptosis is a regulated inflammatory cell death which plays significant role in cancer development and progression. In this study, we evaluated whether genetic variants key regulators of necroptosis may affect survival outcome non‐small lung (NSCLC) patients after surgical resection. Methods A total 674 who underwent curative surgery were included. Fifteen (RIPK1, RIPK3, MLKL) selected. The association these with outcomes was evaluated. Results Two variants, RIPK1...