A5091684835- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Mechanisms of cancer metastasis
- Peptidase Inhibition and Analysis
- Pelvic and Acetabular Injuries
- RNA Research and Splicing
- Atrial Fibrillation Management and Outcomes
- Enzyme Structure and Function
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Hip and Femur Fractures
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Bone fractures and treatments
- Medicinal Plant Pharmacodynamics Research
- Natural product bioactivities and synthesis
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Cancer-related gene regulation
Shandong First Medical University
2014-2025
Shandong Tumor Hospital
2014-2025
Quzhou City People's Hospital
2024
Shandong University
2017
Qilu Hospital of Shandong University
2017
Abstract The role of METTL3-mediated N6-methyladenosine (m 6 A) modification has been elucidated in several cancers, but the concrete mechanism underlying its function colorectal cancer is still obscure. Here, we revealed that upregulated methyltransferase-like 3 (METTL3) exerted both methyltransferase activity-dependent and -independent functions gene regulation. METTL3 deposited m A on 3’ untranslated region JAK1 transcript to promote translation relying YTHDF1 recognition. Besides, was...
Abstract Emerging evidence shows that extracellular vesicles (EVs)‐mediated cargo shuttling between different kinds of cells constantly occurs in the tumor microenvironment, leading to progression a variety cancers, but biological role DNA enriched EVs has not been fully elucidated. Here, nuclear chromatin‐originated fragments were identified human serum‐derived and exhibited mild increase colorectal cancer patient group, unveiling their potential as biomarker for diagnosis. Molecular...
Circulating predictors prognostic factors of neoadjuvant chemotherapy, which identify the patients who are potential possibly to benefit from it limited at present. In this research, we aimed compare significance neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte (PLR) in with locally advance gastric carcinoma were treated chemotherapy (NAC) followed by D2 gastrectomy.From 2007 2015, 91 advanced cancer NAC gastrectomy included retrospective cohort study. The correlation clinical data,...
Mitochondrial respiration and metabolism play a key role in the pathogenesis progression of colon adenocarcinoma (COAD). Here, we report functional pool FKBP4, co-chaperone protein, mitochondrial intermembrane space (IMS) cancer cells. We found that IMS-localized FKBP4 is essential for maintenance respiration, thus contributing to sensitivity COAD cells 5-fluorouracil (5-FU). Mechanistically, interacts with COA6 controls assembly COA6/SCO1/SCO2 complex, thereby governing COA6-regulated...
There is a growing amount of research that highlights the significant connection between development colitis and both metabolic imbalance inflammatory response. Tagatose, an inherent sweetening agent alternative to sugar, plays crucial role in biosynthesis several chemicals pathways living organisms. However, specific biochemical mechanism via which tagatose hinders still not understood. According recent study, safeguarding integrity tight junctions inside intestinal mucosal barrier....
Background Early femoral neck shortening after system (FNS) fixation for displaced fractures can occur in 22.3%–39.1% of cases, leading to decreased hip joint function. This study aimed investigate the effectiveness using an anti‐shortening screw (ASS) FNS prevent postoperative fractures. Methods We retrospectively analyzed 106 cases treated with at Hospital from April 2020 2023. Patients were divided into two groups based on use ASS: traditional group and ASS group, each consisting 53...
Background: Microsatellite instability-high (MSI-H) is a special type of human colon adenocarcinoma (COAD) that responds well to immunotherapy.MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which are important members competing endogenous (ceRNAs) networks, involved in the tumorigenesis development MSI-H COAD.This study aimed establish ceRNA network for MSI COAD identify targets prognostic markers may explain effects immunotherapy.Methods: sequencing data were extracted from The...
As a relic of ancient bacterial endosymbionts, mitochondria play central role in cell metabolism, apoptosis, autophagy, and other processes. However, the function mitochondria-derived nucleic acids cellular signal transduction has not been fully elucidated. Here, our work found that Y-box binding protein 1 (YB1) maintained autophagy at moderate level to inhibit mitochondrial oxidative phosphorylation. In addition, RNA was leaked into cytosol under starvation, accompanied by YB1 relocation,...
The role of radiaotion therapy in resectable gastric cancer patients without distant metastases remains controversial. This retrospective analysis was performed to identify whether might benefit from radiation.The results the Kaplan-Meier and log-rank test showed that a total 3309 had MST 29.0 months, 1-year survival rate 74.7%, 3-year 45.5%. Among them, "RPS" group "RAS" were significantly longer compared with "No Radiation" (32.7vs 32.9 vs 25.3 P < 0.05). rates 83.7%, 83.5% 65.6% for...