A5071320945- Neuroendocrine Tumor Research Advances
- Schizophrenia research and treatment
- Pharmacogenetics and Drug Metabolism
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Genetic factors in colorectal cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Lung Cancer Research Studies
- Nitric Oxide and Endothelin Effects
- Pharmacovigilance and Adverse Drug Reactions
- Climate Change and Health Impacts
- Patient Safety and Medication Errors
- Polyomavirus and related diseases
- Folate and B Vitamins Research
- Smoking Behavior and Cessation
- Trigeminal Neuralgia and Treatments
- Thyroid Disorders and Treatments
- Nutrition and Health in Aging
- Cardiovascular Health and Disease Prevention
- Receptor Mechanisms and Signaling
- Multiple Sclerosis Research Studies
- Glycosylation and Glycoproteins Research
- Migraine and Headache Studies
Sapienza University of Rome
1998-2025
CTO Andrea Alesini
2020-2024
Azienda Ospedaliera Sant'Andrea
2012-2022
Advanced Cell Diagnostics (United States)
2010
The COVID-19/SARS-CoV-2 pandemic struck health, social and economic systems worldwide, represents an open challenge for scientists —coping with the high inter-individual variability of COVID-19, policy makers responsibility to understand environmental factors affecting its severity across different geographical areas. Air pollution has been warned as a modifiable factor contributing differential SARS-CoV-2 spread but biological mechanisms underlying phenomenon are still unknown. quality...
Abstract This study investigates treatment-resistant schizophrenia (TRS) by analysing genetic markers in dopamine and serotonin receptors. Conducted on a cohort of 221 patients with mental disorders, the research focused DRD2 HTR2A gene variants—specifically, rs1801028, rs6314, rs7997012, rs6311. The findings suggest specific associations between certain variants TRS. Notably, rs6314 A|G genotype rs7997012 G|G were significantly more prevalent TRS compared to healthy controls (HCs)....
Abstract Aims To evaluate the effects of gliclazide on oxidative status and vascular response to systemic administration L‐arginine, natural precursor nitric oxide (NO), in Type 2 diabetic patients. Methods Thirty patients received glibenclamide ( n = 15) or a 12‐week, randomized, observer‐blinded, parallel study. Plasma lipid peroxides, total radical‐trapping anti‐oxidant parameter (TRAP), blood pressure responses an intravenous bolus L‐arginine were measured pre‐ post‐treatment. Results At...
The majority of gastroenteropancreatic well-differentiated endocrine carcinomas (WDEC) express somatostatin receptors (SSTR). To correlate the expression SSTR subtypes by reverse transcriptase-polymerase chain reaction (RT-PCR) with clinicopathological features and survival in a group WDEC patients, 42 tissue specimens from 33 patients were analysed. All treated analogues had median follow-up period 45 months (range 6-196). Neither SSTR2 SSTR5 nor Ki-67 level alone correlated survival. A...
Deficiency of dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is associated with severe toxicity induced anti-cancer drug 5-Fluorouracil (5-FU). genotyping four recommended polymorphisms widely used to predict toxicity, yet their prediction power limited. Increasing availability next generation sequencing (NGS) will allow us screen rare variants, predicting a larger fraction DPD deficiencies. Genotype−phenotype correlations were investigated performing exon in 94 patients...
Patients affected by mental disorders smoke more than the general population. The reasons behind this habit are genetic, environmental, etc. This study aims to investigate correlations between some polymorphisms and smoking habits nicotine dependence in patients with psychiatric disorders. We recruited 88 treatment-resistant disorders, including 35 major depressive disorder, 43 bipolar spectrum 10 schizophrenia disorder. carried out a clinical psychometric assessment on current habits, years...
The objective of this study was to investigate the DRD2 rs1800497, rs1799732, rs1801028, DRD3 rs6280, and HTR2A rs6314, rs7997012, rs6311 single-nucleotide polymorphism (SNP) correlations with resistance second-generation antipsychotics (SGAs) in a real-world sample patients treatment-resistant mental disorders.We divided 129 participants into high treatment (HTR) group (current two SGAs, or clozapine, classic neuroleptics for failure previous SGAs trials) low (LTR) one atypical...
Treatment-resistant depression (TRD) reduces affected patients' quality of life and leads to important social health care costs. Pharmacogenomics-guided treatment (PGT) may be effective in the cure TRD. The main aim this study was evaluate clinical changes after PGT patients with TRD (two or more recent failed psychopharmacological trials) by bipolar disorder (BD) major depressive (MDD) compared a control group as usual (TAU). We based on assessing different gene polymorphisms involved...
A proteomic approach was applied to study the protein expression profile of peripheral T-cells derived from patients at onset different B-lymphoproliferative diseases, because a rising interest in specific actions played by such pathologies has emerged. Decreased levels profilin-1 and cofilin-1 increased coronin1A prohibitin were found patients, compared with healthy controls. The protein-protein interaction network these proteins studied using web-based bioinformatics tool, highlighting...
Background: Lower respiratory tract infection (LRTI) is a main cause of hospitalization in infants and children. These patients’ nasopharyngeal swabs more frequently contain syncytial virus (RSV) than human adenovirus (HAdV) cold seasons; recent data suggest that oropharyngeal HAdV RSV. Knowing about detection with swabs, seasonal fluctuations age-related distribution RSV would help treat children hospitalized for LRTI effectively. We investigated the virus-related frequency (as assessed by...
Standard treatment for locally advanced rectal cancer consists of neoadjuvant radiochemotherapy with concomitant fluoropyrimidine or oxaliplatin and surgery curative intent. Pathological complete response has shown to be predictive better outcome survival; nevertheless there are no biological genetic factors treatment. We explored the correlation between single nucleotide polymorphisms (SNPs) GSTP1 (A313G) XRCC1 (G28152A), pathological survival after in patients.Genotypes (G28152A) were...
Improper drug prescription is a main cause of both drug-related harms (inefficacy and toxicity) ineffective spending waste the healthcare system's resources. Nowadays, strategies to support an improved, informed process may benefit from adequate use pharmacogenomic testing. Using next-generation sequencing, we analyzed genomic profile for three major cytochromes P450 (CYP2C9, CYP2C19, CYP2D6) studied frequencies dysfunctional isozymes (e.g., poor, intermediate, or rapid/ultra-rapid...
The kinetics of postvaccination serum anti-Spike IgG concentration were determined in 1,541 health care workers (Sant'Andrea Hospital Rome, Italy) with no prior infection by SARS-COV-2. Anti-Spike measured at 3, 12, and 24 weeks after the completion primary vaccine cycle (two doses BNT162b2 Biontech/Pfizer) 3 apart a third dose. Stratification study population age (decades from 21-30 to 61-70) highlighted that all groups had an order magnitude reduction titers. Considering older adults (age...