A5012758715- Migraine and Headache Studies
- Antimicrobial Peptides and Activities
- Colorectal Cancer Treatments and Studies
- Pharmacogenetics and Drug Metabolism
- Gastric Cancer Management and Outcomes
- Pharmacological Effects and Toxicity Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Proteomics Techniques and Applications
- Gut microbiota and health
- Tryptophan and brain disorders
- Pancreatic and Hepatic Oncology Research
- Health Systems, Economic Evaluations, Quality of Life
- Orthopedic Infections and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Treatment of Major Depression
- Folate and B Vitamins Research
- Invertebrate Immune Response Mechanisms
- Bacterial Identification and Susceptibility Testing
- Metabolomics and Mass Spectrometry Studies
- Monoclonal and Polyclonal Antibodies Research
- Schizophrenia research and treatment
- Fungal and yeast genetics research
- Obstructive Sleep Apnea Research
- Biotin and Related Studies
- Health, Environment, Cognitive Aging
Sapienza University of Rome
2016-2025
CTO Andrea Alesini
2014-2025
Azienda Ospedaliera Sant'Andrea
2011-2024
Museum of Heilongjiang Province
2021
Expert System (Italy)
2017
Istituto Dermopatico dell'Immacolata
2016
Istituti di Ricovero e Cura a Carattere Scientifico
2016
Advanced Cell Diagnostics (United States)
2010
Weatherford College
2010
The COVID-19/SARS-CoV-2 pandemic struck health, social and economic systems worldwide, represents an open challenge for scientists —coping with the high inter-individual variability of COVID-19, policy makers responsibility to understand environmental factors affecting its severity across different geographical areas. Air pollution has been warned as a modifiable factor contributing differential SARS-CoV-2 spread but biological mechanisms underlying phenomenon are still unknown. quality...
The Coronavirus Disease (Covid-19) pandemic is rapidly spreading across the world, representing an unparalleled challenge for health care systems. There are differences in estimated fatality rates, which cannot be explained easily. In Italy, case rate was 12.7% mid-April, while Germany remained at 1.8%. Moreover, it to noted that different areas of Italy have very lethality rates. Due complexity Covid-19 patient management, paramount importance develop a well-defined clinical workflow order...
Prostate cancer (PC) is a frequent male malignancy and represents the second most diagnosed in men. Since pre-cancerous lesions, i.e., high-grade prostatic intraepithelial neoplasia (HGPIN), can be detected years before progression to PC, early diagnosis chemoprevention are targeted strategies reduce PC rates. Animal studies have shown that lycopene, carotenoid contained tomatoes, promising candidate for of PC. However, its efficacy humans remains controversial. The present study aimed...
Type 2 diabetes mellitus (T2DM) is characterized by disrupted glucose homeostasis and metabolic abnormalities, with oxidative stress inflammation playing pivotal roles in its pathophysiology. Poly(ADP-ribosyl)ation (PARylation) a post-translational process involving the addition of ADP-ribose polymers (PAR) to target proteins. While preclinical studies have implicated PARylation interplay between T2DM, direct clinical evidence humans remains limited. This study investigates relationship...
Metabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson's disease (PD). Here we focused on mGlu3, a receptor subtype involved synaptic regulation and neuroinflammation. mGlu3−/− mice showed an enhanced nigro-striatal damage microglial activation response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Expression of genes encoding anti-inflammatory proteins neuroprotective factors was reduced the striatum MPTP-treated mice. We also...
Abstract This study investigates treatment-resistant schizophrenia (TRS) by analysing genetic markers in dopamine and serotonin receptors. Conducted on a cohort of 221 patients with mental disorders, the research focused DRD2 HTR2A gene variants—specifically, rs1801028, rs6314, rs7997012, rs6311. The findings suggest specific associations between certain variants TRS. Notably, rs6314 A|G genotype rs7997012 G|G were significantly more prevalent TRS compared to healthy controls (HCs)....
Treatment-resistant depression (TRD) remains a critical challenge in psychiatry, with limited effective options. Esketamine, rapid-acting antidepressant, is usually combined selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine (SNRI), but comparative evidence of these combinations' effectiveness real-world settings sparse. To determine whether the combination esketamine + SNRI shows differences clinical outcomes compared to SSRI patients TRD. This retrospective cohort...
Mitotane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chloro-phenyl) ethane (o,p'-DDD), is a compound that represents the effective agent in treatment of adrenocortical carcinoma (ACC), able to block cortisol synthesis. In this type cancer, biological mechanism induced by remains still unknown. study, we have already shown greater impairment first steps steroidogenesis and recognized little effect on cell cycle. We also evaluated variation proteomic profile H295R ACC line, either total extract or...
Antimicrobial peptides constitute one of the main classes molecular weapons deployed by innate immune system all multicellular organisms to resist microbial invasion. A good proportion antimicrobial currently known, numbering hundreds molecules, have been isolated from frog skin. Nevertheless, very little is known about effect(s) and mode(s) action amphibian on intact bacteria, especially when they are used at subinhibitory concentrations under conditions closer those encountered in vivo....
Migraine is a common type of headache and its most severe attacks are usually treated with triptans, the efficacy which extremely variable. Several SNPs in genes involved metabolism target mechanisms triptans have been described. To define an association between genetic profile triptan response, we classified migrainous population on basis response characterized it for polymorphisms coding monoamine oxidase A, G protein β3 cytochrome CYP1A2. Analysis genotypic allelic frequencies analyzed...
OPN and Gal‐3 Predict VT/VF in Heart Failure Patients Background Myocardial extracellular matrix remodelling provides electrical heterogeneity entailing ventricular tachycardia/fibrillation (VT/VF) heart failure (HF) patients. Osteopontin (OPN) Galectin‐3 (Gal‐3) are fibrosis markers may reflect the extension of arrhythmogenic substrate. We assessed whether plasma predict risk sustained a cohort HF patients with implantable cardioverter‐defibrillator (ICD). Methods A total 75 underwent...