George T. Lainas

ORCID: 0000-0002-3865-7142
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About
Contact & Profiles
Research Areas
  • Ovarian function and disorders
  • Reproductive Biology and Fertility
  • Assisted Reproductive Technology and Twin Pregnancy
  • Reproductive Health and Technologies
  • Ectopic Pregnancy Diagnosis and Management
  • Reproductive System and Pregnancy
  • Ovarian cancer diagnosis and treatment
  • Pregnancy and preeclampsia studies
  • Renal and related cancers
  • Endometriosis Research and Treatment
  • Phonetics and Phonology Research
  • Reproductive Health and Contraception
  • Delphi Technique in Research
  • Prenatal Screening and Diagnostics
  • Sexual Differentiation and Disorders
  • Maternal and Neonatal Healthcare
  • Sperm and Testicular Function
  • Gynecological conditions and treatments
  • Speech and dialogue systems

Eugonia
2014-2024

Assisting Nature
2013-2023

Aristotle University of Thessaloniki
2019-2020

National and Kapodistrian University of Athens
2005

Abstract STUDY QUESTION What is the recommended management of ovarian stimulation, based on best available evidence in literature? SUMMARY ANSWER The guideline development group formulated 84 recommendations answering 18 key questions stimulation. WHAT IS KNOWN ALREADY Ovarian stimulation for IVF/ICSI has been discussed briefly National Institute Health and Care Excellence fertility problems, Royal Australian New Zealand College Obstetricians Gynaecologist published a statement assisted...

10.1093/hropen/hoaa009 article EN cc-by-nc Human Reproduction Open 2020-01-01

Abstract STUDY QUESTION How should recurrent implantation failure (RIF) in patients undergoing ART be defined and managed? SUMMARY ANSWER This is the first ESHRE good practice recommendations paper providing a definition for RIF together with on how to investigate causes contributing factors, improve chances of pregnancy. WHAT IS KNOWN ALREADY challenge clinic, multitude investigations interventions offered applied clinical practice, often without biological rationale or unequivocal evidence...

10.1093/hropen/hoad023 article EN cc-by-nc Human Reproduction Open 2023-01-01

Women with polycystic ovary syndrome (PCOS) are at risk of developing ovarian hyperstimulation (OHSS) during stimulation. Use GnRH antagonist in the general subfertile population is associated lower incidence OHSS than agonists and similar probability live birth but it unclear if this true for patients PCOS. Our aim was to compare flexible agonist long protocols PCOS undergoing IVF (primary end-point: ongoing pregnancy rate per patient randomized). In randomised controlled trial (RCT), 220...

10.1093/humrep/dep436 article EN Human Reproduction 2009-12-15

STUDY QUESTIONWhat is the proper way of assessing effect progesterone elevation (PE) on day hCG live birth in women undergoing fresh embryo transfer after vitro fertilization (IVF) using GnRH analogues and gonadotrophins?

10.1093/humrep/deu362 article EN Human Reproduction 2015-01-12

Although initial studies in poor responders using GnRH antagonists have reported encouraging results, they are limited number, only a few of them prospective, while the majority is characterized by power to detect clinically important difference. A randomized controlled trial was performed patients with one or more previous failed IVF cycles which five less oocytes were retrieved, ≥300 IU gonadotrophins/day. Patients computer-generated list and treated either flare-up agonist protocol (n =...

10.1093/humrep/den107 article EN Human Reproduction 2008-04-11

STUDY QUESTIONDo live birth rates differ between modified natural cycles (MNCs) and using high-dose follicle stimulating hormone (HDFSH) with gonadotrophin-releasing (GnRH) antagonist in poor responder patients?

10.1093/humrep/dev198 article EN Human Reproduction 2015-08-25

Management of established severe OHSS requires prolonged hospitalization, occasionally in intensive care units, accompanied by multiple ascites punctures, correction intravascular fluid volume and electrolyte imbalance. The aim the present study was to evaluate whether it is feasible manage women with as outpatients treating them GnRH antagonists luteal phase.This a single-centre, prospective, observational, cohort study. Forty patients diagnosed OHSS, five days post oocyte retrieval, were...

10.1186/1477-7827-10-69 article EN cc-by Reproductive Biology and Endocrinology 2012-08-31

Are there any baseline predictors of progesterone elevation (PE) on the day human chorionic gonadotrophin (hCG) which are not associated with intensity ovarian stimulation in women undergoing vitro fertilization (IVF) using follicle stimulating hormone (FSH) and gonadotrophin-releasing (GnRH) antagonists? Basal (Day 2 menstrual cycle) serum concentration history PE variables that can predict occurrence hCG independently stimulation. is magnitude response to For this reason, it has been...

10.1093/humrep/dew141 article EN Human Reproduction 2016-06-14

STUDY QUESTIONDo high-risk patients who develop severe early ovarian hyperstimulation syndrome (OHSS) and receive low-dose GnRH antagonist in the luteal phase have lower live birth rates compared with do not OHSS phase?

10.1093/humrep/det114 article EN Human Reproduction 2013-04-26

The purpose of the study was to assess ongoing pregnancy rates across groups patients treated by IVF, which were defined according criteria aimed at prevention premature LH surge and used for initiating GnRH antagonist.This is a prospective observational cohort study. During last 3 years, in IVF-ICSI undergoing controlled ovarian stimulation (COS) with antagonist protocol, administration initiated least one following patient-specific criteria: (i) follicle measuring >14 mm; (ii) estradiol...

10.1093/humrep/dei106 article EN Human Reproduction 2005-06-09

The optimal time for GnRH antagonist initiation is still debatable. purpose of the current randomized controlled trial to provide endocrine and follicular data during ovarian stimulation IVF in patients with polycystic syndrome (PCOS) treated either a long agonist scheme or fixed day-1 protocol. Randomized both groups (antagonist: n = 26; agonist: 52) received oral contraceptive pill treatment three weeks starting dose 150 IU follitropin β. primary outcome was E2 level on Day 5 stimulation,...

10.1093/humrep/dem033 article EN Human Reproduction 2007-03-08

Abstract STUDY QUESTION Does follicular flushing increase the number of cumulus–oocyte complexes (COCs) retrieved compared to single aspiration? SUMMARY ANSWER Follicular significantly increases COCs aspiration. WHAT IS KNOWN ALREADY On basis published meta-analyses, does not seem oocytes retrieved, probability clinical pregnancy, or that live birth and has been associated with an in duration oocyte retrieval. It should be noted, however, all eligible randomized controlled trials (RCTs)...

10.1093/humrep/dead169 article EN Human Reproduction 2023-08-25

ABSTRACT Objective To assess ultrasound and hematological changes during the early luteal phase following triggering of final oocyte maturation with human chorionic gonadotropin (hCG) in women at high risk for developing ovarian hyperstimulation syndrome (OHSS). Methods This was a retrospective cohort study 319 undergoing in‐vitro fertilization who were OHSS administration hCG maturation. Patients treated gonadotropin‐releasing hormone agonist or antagonist protocol monitored 5 days...

10.1002/uog.18949 article EN Ultrasound in Obstetrics and Gynecology 2018-01-01

The presence of smooth endoplasmic reticulum aggregates (SERa) in the ooplasm is considered as most severe oocyte dysmorphism due to its serious and potentially lethal outcomes offspring. In present case report, a couple underwent their first intracytoplasmic sperm injection (ICSI) cycle using gonadotrophin releasing hormone (GnRH) antagonist protocol, followed by fetal ultrasound scanning amniocentesis. SERa were observed all oocytes retrieved. A singleton pregnancy was established. second...

10.1080/19396368.2018.1466375 article EN Systems Biology in Reproductive Medicine 2018-05-02
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