A5075341735- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Iron Metabolism and Disorders
- Amyotrophic Lateral Sclerosis Research
- Blood properties and coagulation
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Electrochemical sensors and biosensors
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Blood groups and transfusion
- PARP inhibition in cancer therapy
- Alzheimer's disease research and treatments
- Conducting polymers and applications
- Protein purification and stability
- Carbon and Quantum Dots Applications
- Microfluidic and Bio-sensing Technologies
- Gas Sensing Nanomaterials and Sensors
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric health and respiratory diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Carcinogens and Genotoxicity Assessment
- Molecular Junctions and Nanostructures
Changchun Institute of Optics, Fine Mechanics and Physics
2025
Chinese Academy of Sciences
2025
Dalian University
2024
Dalian University of Technology
2024
Beijing University of Technology
2021
University of Minnesota
2016-2018
Center for Clinical Research (United States)
2018
Oregon Health & Science University
2005-2010
Purdue University West Lafayette
2010
Abstract Background The management of myocardial ischemia–reperfusion injury (MIRI) presents continuous therapeutic challenges. NAD-dependent deacetylase Sirtuin 6 (Sirt6) plays distinct roles in various disease contexts and is hence investigated for potential applications MIRI. This study aimed to examine the impact Sirt6-overexpressing exosomes derived from adipose stem cells (S-ASC-Exo) on MIRI, focusing their influence AIM2-pyroptosis mitophagy processes. sirtuin family proteins,...
The nature of the different kinesin family members that function in a single, specific neuron type has not been systematically investigated. Here, we used quantitative real-time PCR to analyze developmental expression patterns genes cultured mouse hippocampal neurons, highly homogeneous population nerve cells. For purposes comparison, also determined set kinesins expressed embryonic and adult tissue. Twenty are at moderate-to-high levels mature cultures. These include 9 plus-end directed...
AHN649, an analog of dextromethorphan (DM) and a relatively selective low-affinity N-methyl-D-aspartate antagonist, was evaluated for neuroprotective effects using the rat intraluminal filament model temporary middle cerebral artery occlusion. Rats were subjected to 2 h focal ischemia followed by 72 reperfusion. In vehicle-treated rats, occlusion resulted in neurological deficits severe infarction measuring 232 +/- 25 mm(3), representing approximately 25% contralateral hemispheric...
Abstract Although homozygous sickle cell disease is often clinically severe, the corresponding heterozygous state, trait, almost completely benign despite fact that there only a modest difference in hemoglobin levels between two conditions. In both conditions, hypoxia can lead to polymerization of hemoglobin, changes red mechanical properties, and impaired blood flow. Here, we test hypothesis differences oxygen‐dependent rheological properties conditions might help explain clinical...
The genotoxicant methylazoxymethanol (MAM) is a widely used developmental neurotoxin, and its glucoside an etiological factor for western Pacific amyotrophic lateral sclerosis-parkinsonism-dementia complex (ALS/PDC). Identification of global protein expression changes that occur in response to MAM the developing cerebellum could provide valuable insight into potential mechanisms involved neurodegeneration process. We have utilized fluorescence 2-dimensional differential gel electrophoresis...
Understanding changes in the properties of semiconductor materials after immobilization biomolecules on surface is essential for fabrication well-tuned and programmable devices. The work examines gallium phosphide (GaP) modification with an organic linker, a single stranded DNA, its complementary strand. We investigated potential Kelvin probe force microscopy (KPFM). Analysis revealed that more ordered adlayer ssDNA was present when lower concentration linker molecule used. KPFM data...
Three efficiency tests for single-use AEX chromatography devices have been developed and applied to six capsule formats of a new, salt tolerant, product. All the designed be performed with simple equipment common reagents. By performing each three on undamaged capsules intentionally damaged small defects, in tandem Phi-X174 challenges high-salt buffer, relationships between test results viral clearance obtained. A pre-use pressure-based installation verification is simply during...
Objective: To analyze the dynamic changes of clinical features chronic rhinosinusitis in recent 10 years, so as to deeply understand characteristics rhinosinusitis, and provide new ideas for treatment rhinosinusitis. Method: This retrospective study was performed patients who were diagnosed enrolled. General information, examination pathological results all collected, then patients' age, gender, incidence asthma allergic rhinitis, peripheral eosinophil percentage, olfactory dysfunction...