A5101616703- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Knee injuries and reconstruction techniques
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Hip disorders and treatments
- Healthcare Systems and Reforms
- Body Composition Measurement Techniques
- Musculoskeletal synovial abnormalities and treatments
- Extracellular vesicles in disease
- Orthopedic Surgery and Rehabilitation
- Sarcoma Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Sirtuins and Resveratrol in Medicine
- Breast Cancer Treatment Studies
- Advanced MRI Techniques and Applications
- Digital Marketing and Social Media
- Ocular Oncology and Treatments
- Global Maternal and Child Health
- Anesthesia and Pain Management
- Sentiment Analysis and Opinion Mining
- PARP inhibition in cancer therapy
- Cancer Mechanisms and Therapy
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
General Hospital of Shenyang Military Region
2024
Third Affiliated Hospital of Southern Medical University
2024
First Hospital of China Medical University
2024
China Medical University
2024
Peking Union Medical College Hospital
2019-2023
Affiliated Zhongshan Hospital of Dalian University
2022
Marymount University
2021
Jilin University
2021
Hunan Provincial People's Hospital
2019
Abstract Background The management of myocardial ischemia–reperfusion injury (MIRI) presents continuous therapeutic challenges. NAD-dependent deacetylase Sirtuin 6 (Sirt6) plays distinct roles in various disease contexts and is hence investigated for potential applications MIRI. This study aimed to examine the impact Sirt6-overexpressing exosomes derived from adipose stem cells (S-ASC-Exo) on MIRI, focusing their influence AIM2-pyroptosis mitophagy processes. sirtuin family proteins,...
Patient-reported outcome measures (PROMs) are being used increasingly in total knee arthroplasty (TKA). We conducted a systematic review aimed at identifying psychometrically sound PROMs by appraising their measurement properties. Studies concerning the development and/or evaluation of properties TKA population were systematically retrieved via PubMed, Web Science, Embase, and Scopus. Ratings for methodological quality according to updated COnsensus-based Standards selection health...
Background Accurate preoperative planning is essential for successful total hip arthroplasty (THA). However, the requirements of time, manpower, and complex workflow accurate have limited its application. This study aims to develop a comprehensive artificial intelligent system THA (AIHIP) validate accuracy in clinical performance. Methods Over 1.2 million CT images from 3,000 patients were included an intelligence (AIHIP). Deep learning algorithms developed facilitate automatic image...
Aims The value of core decompression (CD) in the treatment osteonecrosis femoral head (ONFH) remains controversial. We conducted a systematic review and meta-analysis to evaluate whether CD combined with other treatments could improve clinical radiological outcomes ONFH patients compared alone. Methods searched PubMed, Embase, Web Science, Cochrane Library databases until June 2020. All randomized controlled trials (RCTs) (CCTs) comparing alone measures (CD + cell therapy, bone grafting,...
Aims The diagnosis of periprosthetic joint infection (PJI) has always been challenging. Recently, D-dimer become a promising biomarker in diagnosing PJI. However, there is controversy regarding its diagnostic value. We aim to investigate the value comparison ESR and CRP. Methods PubMed, Embase, Cochrane Library were searched February 2020 identify articles reporting on Pooled analysis was conducted D-dimer, CRP, ESR. Results Six studies with 1,255 cases included (374 PJI 881 non-PJI cases)....
Objective This study aims to compare the accuracy of CT‐based preoperative planning with that acetate templating in predicting implant size, neck length, and cut evaluate reproducibility two methods. Methods prospective was conducted between August 2020 March 2021. Patients who underwent elective primary total hip arthroplasty by a single surgeon were assessed for eligibility. The included patients both observers after operation. Each observer twice each case. outcome measures following: (1)...
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Studies have shown that bradykinin (BK) highly expressed in liver cancer. We designed novel BK receptor inhibitors J051-71 and J051-105, which reduced viability of cells inhibited formation cell colonies. J051-105 proliferation induced apoptosis HepG2 BEL-7402 cells, may be due to inhibition extracellular regulated protein kinase (ERK) signaling pathway. In addition, these reversed by downregulating B1 expression....
Objectives Mechanical alignment (MA)‐total knee arthroplasty (TKA) has been challenged due to the excessive soft tissue release and evidence of clinical outcomes computer assisted navigation is still limited. The aim this ambispective cohort study was to: (i) investigate whether capable achieve restricted kinematic (rKA)‐TKA; (ii) compare short‐term between rKA‐TKA MA‐TKA. Methods We retrospectively included 41 patients diagnosed with osteoarthritis who received MA‐TKA April 2019 January...
To examine the accuracy, reliability, and reproducibility of a simple preoperative planning technique using plain X-rays.A retrospective analysis 96 consecutive cases primary direct anterior approach (DAA)-total hip arthroplasty (THA) from July 2015 to December 2018 was performed. The patients included 24 males 72 females, with an average age 70 years. standard AP pelvis radiographs patients' hips extended internally rotated were obtained pre- postoperatively. also completed on standardized...
The best way in which to prepare scaffolds with good biological properties is an urgent problem the field of tissue engineering. In this paper we discuss preparation nano-hydroxyapatite scaffold recombinant human bone morphogenetic protein-2 (rhBMP-2) and its application defect repair. rhBMP-2 reagent was dissolved 1 mol/L sodium dihydrogen phosphate solution, solution added artificial a 100 μ L glass micro dropper at rate 10 drops/min obtain Nano-HA/rhBMP-2 composite bone. vivo experiments,...
Abstract Background Fibrinogen (Fbg) and D-dimer have been used as biomarkers for the diagnosis of periprosthetic joint infection (PJI). However, previous research has reported conflicting results on diagnostic value in comparison to Fbg, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR). Aim This study aimed to: (1) determine optimal threshold plasma Fbg PJI compare their that CRP ESR; (2) investigate whether perform differently than ESR indicators different types PJI. Methods...
Objective Venous thromboembolism (VTE) is a significant concern post total joint arthroplasty (TJA). However, the optimal prevention method of VTE remains controversial at present. This study aims to evaluate risk‐stratified prophylaxis protocol for patients undergoing TJA. Methods A 891 TJA from January 2011 November 2019 were retrospectively investigated. The was divided into two cohorts. In cohort 1, 410 (250 females and 160 males, mean age 64.32 years) treated with an aggressive...
Whether neutral alignment brings better clinical outcomes is controversial. Consideration of the preoperative knee condition patients and some limitations previous studies, we suggested that other index may be more important than a generic target 0° ± 3° axis to reflect changes in coronal after total replacement (TKR). The purpose this study was explore relationship between functional outcome with new grouping method concept correction rate.The included 358 knees, mean follow-up period 3.62...
At present, there is no early prediction model of left ventricular reverse remodeling (LVRR) for people who are in cardiac arrest with an ejection fraction (EF) ≤35% at first diagnosis; thus, the purpose this article to provide a supplement existing research.