A5044335014- Mast cells and histamine
- Enzyme function and inhibition
- Synthesis and Catalytic Reactions
- Asthma and respiratory diseases
- Sirtuins and Resveratrol in Medicine
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- PARP inhibition in cancer therapy
- Protein Degradation and Inhibitors
- Biblical Studies and Interpretation
- Immune responses and vaccinations
- Neuroscience of respiration and sleep
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- Historical and Linguistic Studies
- Archaeology and Historical Studies
- Eosinophilic Esophagitis
- Fungal and yeast genetics research
- Histone Deacetylase Inhibitors Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phenothiazines and Benzothiazines Synthesis and Activities
- Food Allergy and Anaphylaxis Research
- Thermal Regulation in Medicine
- Antifungal resistance and susceptibility
Rutgers, The State University of New Jersey
2015-2020
Rutgers New Jersey Medical School
2015-2020
Johnson University
2016
Rutgers Sexual and Reproductive Health and Rights
2016
International Center for Public Health
2015
Linfield College
1928
Type 2 cytokine responses are necessary for the development of protective immunity to helminth parasites but also cause inflammation associated with allergies and asthma. Recent studies have found that peripheral hematopoietic progenitor cells contribute type cytokine–mediated through their enhanced ability develop into mast cells. In this study, we show carbonic anhydrase (Car) enzymes up-regulated in 2–associated demonstrate Car enzyme inhibition is sufficient prevent mouse cell after...
Anti-helminth responses require robust type 2 cytokine production that simultaneously promotes worm expulsion and initiates the resolution of helminth-induced wounds hemorrhaging. However, how infection-induced changes in hematopoiesis contribute to these seemingly distinct processes remains unknown. Recent studies have suggested existence a hematopoietic progenitor with dual mast cell-erythrocyte potential. Nonetheless, whether progenitors host protection during an active infection be...
Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain highly conserved extreme C-terminus called FRAP-ATM-TRRAP-C-terminal (FATC) domain. In budding yeast, ATR correspond to Tel1 Mec1, respectively. this study, we characterized functions of FATC domain by introducing substitution or truncation mutations. One mutation, termed tel1-21, tel1-ΔC, did not significantly affect expression level....
Abstract Type 2 cytokine responses are necessary for the development of protective immunity to helminth parasites but also cause inflammation associated with allergies and asthma. Recent studies have found that peripheral hematopoietic progenitor cells contribute type cytokine-mediated through their enhanced ability develop into mast cells. Here we show carbonic anhydrase (Car) enzymes upregulated in 2-associated demonstrate Car enzyme inhibition is sufficient prevent murine cell following...
Abstract Basophils are innate immune cells associated with type 2 immunity, allergic reactions, and host defense against parasite infections. In this study, we show that the transcription factor PLZF, which is known for its essential role in function development of several lymphocyte subsets, also important myeloid-derived basophil lineage. PLZF-deficient mice had decreased numbers progenitors bone marrow mature basophils multiple peripheral tissues. Functionally, were less responsive to IgE...
<h3>Background</h3> Resveratrol (3,4',5-trihydroxystilbene), a stilbenoid isolated from many species of plants, is widely known for its antioxidative, anti-inflammatory, immunomodulatory and anticancer activities. Recently, novel resveratrol oligomers have been various plants; their diverse structures are characterized by the polymerization two or more units. Little regarding immunomodulating activities these oligomers. In this study, we designed in vitro models to compare side with natural...
Abstract Type 2 cytokine responses are necessary for the development of protective immunity to helminth parasites but also cause detrimental inflammation associated with allergies and asthma. Recent studies have found that peripheral hematopoietic progenitor cell populations contribute type cytokine-mediated through their enhanced ability develop into mast cells. Here we identify carbonic anhydrase (Car) enzymes upregulated in 2-asscoaited cells demonstrate Car enzyme inhibition was...
Abstract Neutropenia is a significant risk factor for life threatening invasive fungal infections (IFI). Neutrophils are well known as important innate cells that promote the direct eradication of pathogens but whether they mediate antifungal defense beyond their role effectors unclear. Here we demonstrate pulmonary infection with clinically relevant pathogen Aspergillus fumigatus induces diversification specialized neutrophils required CCR2+ monocyte-derived dendritic cell (mo-DC) function....
Abstract Basophils are the most rare granulocyte population, accounting for less than 1% of circulating leukocytes in mice and human. Recent studies have shown that basophils associated with multiple immunological processes, such as allergic diseases, autoimmunity, protective immunity against parasites. It has been show rapid secretion Th2 cytokines by response to various stimuli plays key roles parasitic infections. also release histamine and, therefore, contributors allergy. In addition,...
Abstract In situ hematopoiesis (ISH) refers to the differentiation of hematopoietic stem/progenitor cells (HSPCs) into effector that occurs at active sites inflammation. Previous studies have demonstrated ISH contributes population expansion basophil and mast cell populations in context multiple helminth infections. However, whether ISH-derived are critical regulators TH2 cytokine-mediated inflammation protective immunity parasites remain unknown. Here, we demonstrate a previously...
Stilbenoids are a group of naturally occurring phenolic compounds produced de novo in many plant species to protect against fungal infection and toxins. Resveratrol (3,4’,5-trihydroxystilbene), stilbenoid isolated from grapes plants, is widely known for its extensive bioactivities, such as antioxidation, anti-inflammatory anticancer effects. Recently, novel resveratrol oligomers have been various plants. While their structures diverse, these characterized by the polymerization two or more...
<h3>Background</h3> Targeted protein degradation is a rapidly exploding drug discovery strategy which uses small molecules to recruit disease-causing proteins for rapid destruction via the ubiquitin-proteasome pathway. It shows great potential treating diseases such as cancer, autoimmune, infectious, inflammatory, and other diseases, especially those with "undruggable" pathogenic targets. Here we report one 'molecular glue' type of degrader NBT-018, binds cereblon (CBRN) has selective...