A5029652318- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Endoplasmic Reticulum Stress and Disease
- Nanoplatforms for cancer theranostics
- Vibrio bacteria research studies
- Metal-Organic Frameworks: Synthesis and Applications
- Antimicrobial Peptides and Activities
- Cellular transport and secretion
- Nanoparticle-Based Drug Delivery
- Nasal Surgery and Airway Studies
- Dendrimers and Hyperbranched Polymers
- Nuclear Issues and Defense
- Corneal Surgery and Treatments
- Pancreatic function and diabetes
- Ocular Infections and Treatments
- Cell death mechanisms and regulation
- Antibiotics Pharmacokinetics and Efficacy
- Facial Rejuvenation and Surgery Techniques
- Korean Peninsula Historical and Political Studies
- Protein Degradation and Inhibitors
- Advanced Nanomaterials in Catalysis
- Intraocular Surgery and Lenses
- Middle East and Rwanda Conflicts
- Microtubule and mitosis dynamics
- Antibiotic Use and Resistance
University of Liverpool
2015-2024
Ingenierie des Materiaux polymeres
2019
Institut des Sciences Moléculaires d'Orsay
2019
Université Paris-Sud
2019
Université Paris-Saclay
2019
Centre National de la Recherche Scientifique
2019
Covalent EGFR family inhibitors bind to and induce the degradation of pseudokinase TRIB2 kill cancer cells.
Abstract Combinatorial drug therapies emerge among the most promising strategies to treat complex pathologies such as cancer and severe infections. Biocompatible nanoparticles of mesoporous iron carboxylate metal–organic framework (nanoMOFs) are used here address challenging aspects related coincorporation two antibiotics. Amoxicillin potassium clavulanate, a typical example drugs in tandem, efficiently coincorporated with payloads up 36 wt%. Due occurrence distinct pore sizes/apertures...
Pseudomonas aeruginosa has recently been highlighted by the World Health Organisation (WHO) as a major threat with high priority for development of new therapies. In severe P. infections, phospholipase activity type 3 secretion system toxin, ExoU, induces lysis target host cells and results in poorest clinical outcomes. We have developed an integrated pipeline to evaluate small molecule inhibitors ExoU vitro cultured cell models, including disease-relevant corneal epithelial (HCE-T) scratch...
The opportunistic pathogen Pseudomonas aeruginosa is one of leading causes disability and mortality worldwide the world health organisation has listed it with highest priority for need new antimicrobial therapies. P. strains responsible poorest clinical outcomes express either ExoS or ExoU, which are injected into target host cells via type III secretion system (T3SS). a bifunctional cytotoxin that promotes intracellular survival invasive by preventing targeting bacteria to acidified...
Infection models are essential tools for understanding host-pathogen interactions and developing noveltherapies. Ex vivo infection offer significant ethical practical advantages, enabling more accurate physiologically relevant insights compared to traditional cell culture systems. The versatility of porcine corneal ex has made them valuable studying a range ofpathogens, including Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae, Candida albicans, Acanthamoeba, viruses...
Microbial keratitis (MK) is a substantial cause of clinical blindness worldwide. Pseudomonas aeruginosa an opportunistic gram-negative bacterium and the leading MK. Infection models are vital tools in understanding host-pathogen interactions development novel therapies. As well as ethical practical advantages, ex vivo infection can allow researchers to better investigate more accurately than traditional cell culture systems. The versatility porcine corneal have been employed study various...
As demonstrated by Ruxendra Gref and co-workers in article number 1800360, two synergic drugs, amoxicillin potassium clavulanate, were co-encapsulated within highly porous nanoparticles made of metal-organic frameworks (nanoMOFs). Within the interconnected 3D structure, each drug located a separate compartment these findings supported molecular simulations. NanoMOFs efficiently internalized infected macrophages contributed together with entrapped drugs to kill intracellular bacteria.
ONE SENTENCE SUMMARY A Tribbles 2 pseudokinase small molecule screen led to the identification of known EGFR/HER2 inhibitors that alter stability TRIB2 in vitro and lead rapid on-target degradation human cancer cells. SHORT ABSTRACT (TRIB2) is a cancer-associated with diverse interactome, including AKT signaling module. Substantial evidence demonstrates dysregulation important multiple tumors. The non-canonical domain contains unique cysteine rich region interacts peptide motif its own...
The situation on the Korean peninsula has shown to be in a stalemate, despite new levels of hostility and threats between both nations. It would seem that North regime successfully gone through another power transition with Kim Jong Un. issue nuclear proliferation Peninsula remains unresolved tensions rise as rhetoric increases, along their efforts develop capabilities. South Korea consider alternative methods deterrence, assurance umbrella from United States not stopped intentions become...
Abstract The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of disability and mortality worldwide the World Health Organisation has listed it with highest priority for need new therapies. P. strains that express ExoU are implicated in worst clinical outcomes. phospholipase secreted by directly into cytoplasm target host cells, where its catalytic activity, directed towards plasma membranes, causes rapid cell lysis. Inhibition may be novel strategy to combat acutely...
*Correspondence - Stephen Kaye: S.B.Kaye@liverpool.ac.uk INTRODUCTION: Pseudomonas aeruginosa injects toxins, ExoS or ExoU, into host cells via the type III secretion system (T3SS) which destroy and help evade immune system. First-line fluoroquinolones demonstrate better in vitro activity against P. but certain clinical situations aminoglycosides are more effective. We evaluate effects of (moxifloxacin ciprofloxacin) (tobramycin gentamycin) on T3SS toxin expression, associated toxicity...