A5066427673- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Genomics and Chromatin Dynamics
- Advanced biosensing and bioanalysis techniques
- Healthcare and Venom Research
- Plant Genetic and Mutation Studies
- RNA and protein synthesis mechanisms
- Insect Resistance and Genetics
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Microtubule and mitosis dynamics
- Bee Products Chemical Analysis
- Genome Rearrangement Algorithms
- Oral and gingival health research
- HIV/AIDS oral health manifestations
- Animal Genetics and Reproduction
- Hippo pathway signaling and YAP/TAZ
- RNA Interference and Gene Delivery
- Entomological Studies and Ecology
- Cellular Mechanics and Interactions
- Herpesvirus Infections and Treatments
- Oral microbiology and periodontitis research
Centre National de la Recherche Scientifique
2009-2024
Collège de France
2018-2024
Centre Interdisciplinaire de Recherche en Biologie
2018-2024
Inserm
2009-2024
Université Paris Sciences et Lettres
2018-2024
Institut de Biologie Paris-Seine
2015-2019
Sorbonne Université
2012-2019
Université Paris Cité
2015
Epigénétique et Destin Cellulaire
2015
Laboratoire de Biologie du Développement
2012-2015
Abstract Transposable element activity is repressed in the germline animals by PIWI-interacting RNAs (piRNAs), a class of small produced genomic loci mostly composed TE sequences. The mechanism induction piRNA production these still enigmatic. We have shown that, Drosophila melanogaster, cluster tandemly repeated P-lacZ-white transgenes can be activated for maternal inheritance cytoplasm containing homologous piRNAs. This state stably transmitted over generations and allows trans-silencing...
Transposable element (TE) activity is repressed in animal gonads by PIWI-interacting RNAs (piRNAs) produced piRNA clusters. Current models flies propose that germinal clusters are functionally defined the maternal inheritance of piRNAs during previous generation. Taking advantage an inactive, but ready to go, cluster P-element derived transgene insertions Drosophila melanogaster, we show here raising at high temperature (29°C) instead 25°C triggers stable conversion this locus from inactive...
Abstract The study of P transposable element repression in Drosophila melanogaster led to the discovery trans-silencing effect (TSE), a homology-dependent mechanism by which P-transgene inserted subtelomeric heterochromatin (Telomeric Associated Sequences) represses trans, female germline, homologous P-lacZ transgene euchromatin. TSE shows variegation ovaries and displays maternal as well epigenetic transmission through meiosis. In addition, is highly sensitive mutations affecting components...
Transposable element (TE) activity is repressed in the Drosophila germline by Piwi-Interacting RNAs (piRNAs), a class of small non-coding RNAs. These piRNAs are produced discrete genomic loci containing TE fragments. In recent publication, we tested for existence strict epigenetic induction piRNA production capacity locus D. melanogaster genome. We used 2 lines carrying transgenic 7-copy tandem cluster (P-lacZ-white) at same site. This generates both local heterochromatic sector. One line...
ABSTRACT Abscission is the final step of cytokinesis that allows physical separation sister cells through scission cellular membrane. This deformation driven by ESCRT-III proteins, which can bind membranes and form dynamic helices. A crucial in abscission recruitment proteins at right time place. Alix one best characterized recruits from yeast to mammals. However, recent studies vivo have revealed pathways acting independently or redundantly with are also required sites different contexts....
Piwi-interacting RNAs (piRNAs) ensure transposable element silencing in Drosophila, thereby preserving genome integrity across generations. Primary piRNAs arise from the processing of long RNA transcripts produced germ line by a limited number telomeric and pericentromeric loci. bound to Argonaute protein Aubergine then drive production secondary through “ping-pong” amplification mechanism that involves an interplay with Argonaute-3. We recently discovered clusters P-element-derived...
La paramutation : une conversion épigénétique découverte chez les plantesDe nombreuses dérégulations de gènes interviennent sans qu'il puisse être observé modification leur séquence d'ADN.Ces dérégulations, qui peuvent à l'origine dysfonctionnements cellulaires, proviennent modifications affectant la méthylation l'ADN et/ou des protéines associées l'ADN, ou encore production petits ARN non codants interfèrent avec l'expression ces gènes.De telles sont, dans certains cas, transmises travers...
ABSTRACT Transposable element (TE) activity is repressed in animal gonads by PIWI-interacting RNAs (piRNAs), a class of small produced specific loci made TEs insertions and fragments. Current models propose that these are functionally defined the maternal inheritance piRNAs during previous generation, raising question their first activation absence piRNAs. Taking advantage an inactive cluster P -element derived transgene insertions, we show here flies at high temperature (29°C) instead 25°C...