A5077984459- Microtubule and mitosis dynamics
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- RNA modifications and cancer
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Plant Molecular Biology Research
- Genomics and Chromatin Dynamics
- Plant Reproductive Biology
- Cancer-related molecular mechanisms research
- Insect behavior and control techniques
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Hippo pathway signaling and YAP/TAZ
- Insect symbiosis and bacterial influences
- Developmental Biology and Gene Regulation
- Cellular transport and secretion
- Genetics, Aging, and Longevity in Model Organisms
- DNA Repair Mechanisms
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
Stanford University
2022-2025
Inserm
2014-2024
Centre National de la Recherche Scientifique
2014-2024
Collège de France
2024
Centre Interdisciplinaire de Recherche en Biologie
2024
Université Paris Sciences et Lettres
2024
Institut Curie
2014-2015
Abscission is the final event of cytokinesis that leads to physical separation two daughter cells. Recent technical advances have allowed a better understanding cellular and molecular events leading abscission in isolated yeast or mammalian However, how regulated different cell types developing organism remains poorly understood. Here, we characterized function ESCRT-III protein Shrub during germ cells undergoing series complete incomplete divisions. We found required for abscission, levels...
Regulators of chromatin accessibility play key roles in cell fate transitions, triggering onset novel transcription programs as cells differentiate. In the Drosophila male germ line stem lineage, tMAC, a master regulator spermatocyte differentiation that binds thousands loci, is required for local opening chromatin, allowing activation spermatocyte-specific promoters. Here we show cell-type specific surveillance system involving multiple zinc finger protein Kmg and pipsqueak domain Dany...
Alternative cleavage and polyadenylation (APA) often results in production of mRNA isoforms with either longer or shorter 3′ UTRs from the same genetic locus, potentially impacting translation, localization, stability. Developmentally regulated APA can thus make major contributions to cell type-specific gene expression programs as cells differentiate. During Drosophila spermatogenesis, ∼500 genes undergo when proliferating spermatogonia differentiate into spermatocytes, producing transcripts...
During meiosis, germ cell and stage-specific components impose additional layers of regulation on the core cycle machinery to set up an extended G2 period termed meiotic prophase. In Drosophila males, prophase lasts 3.5 days, during which spermatocytes upregulate over 1800 genes grow 25-fold. Previous work has shown that regulator Cyclin B (CycB) is subject translational repression in immature spermatocytes, mediated by RNA-binding protein Rbp4 its partner Fest. Here, we show...
Alternative Cleavage and Polyadenylation (APA) often results in production of mRNA isoforms with either longer or shorter 3'UTRs from the same genetic locus, potentially impacting translation, localization stability. Developmentally regulated APA can thus make major contributions to cell-type-specific gene expression programs as cells differentiate. During
ABSTRACT Abscission is the final step of cytokinesis that allows physical separation sister cells through scission cellular membrane. This deformation driven by ESCRT-III proteins, which can bind membranes and form dynamic helices. A crucial in abscission recruitment proteins at right time place. Alix one best characterized recruits from yeast to mammals. However, recent studies vivo have revealed pathways acting independently or redundantly with are also required sites different contexts....
The switch from precursor cell proliferation to onset of differentiation in adult stem lineages must be carefully regulated produce sufficient progeny maintain and repair tissues, yet prevent overproliferation that may enable oncogenesis. In the