A5101443427- Pharmacological Effects of Natural Compounds
- Rough Sets and Fuzzy Logic
- Medicinal Plants and Bioactive Compounds
- Estrogen and related hormone effects
- Nutritional Studies and Diet
- Plant-based Medicinal Research
- Liver Disease Diagnosis and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Text and Document Classification Technologies
- Family Support in Illness
- HIV/AIDS drug development and treatment
- PI3K/AKT/mTOR signaling in cancer
- Nutrition, Genetics, and Disease
- Respiratory viral infections research
- Genetics, Aging, and Longevity in Model Organisms
- Recommender Systems and Techniques
- Neurological Disease Mechanisms and Treatments
- Andrographolide Research and Applications
- RNA regulation and disease
- Hypothalamic control of reproductive hormones
Twelfth Guangzhou City People's Hospital
2008-2025
Guangxi University
2024
Sun Yat-sen University
2024
Boys Town National Research Hospital
2024
Xi'an Medical University
2020-2023
Tsinghua University
2017-2023
Weatherford College
2023
Center for Life Sciences
2017-2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2020
Shanghai University of Traditional Chinese Medicine
2020
Abstract The aim of this study was to explore the relationships among gut microbiota disturbances and serum spinal cord metabolic disorders in neuropathic pain. 16S rDNA amplicon sequencing metabolomics were used identify alterations metabolite profiles sham rats chronic constriction injury (CCI) model rats. Correlations between abundances components at genus level, levels metabolites, pain-related behavioural parameters analysed. Ingenuity pathway analysis (IPA) applied analyse interaction...
Studies on the trajectories of lipid profile with cognitive decline are scarce and inconsistent. We examined this association explored potential effect modification. Lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), triglycerides (TG) total (TC) were measured at baseline, first second follow-ups, classified into trajectory groups. Immediate, delayed memory recall function assessed by immediate (IWRT) 10-word test (DWRT), mini-mental state examination...
Progesterone secretion by the steroidogenic cells of corpus luteum (CL) is essential for reproduction. synthesis under control LH, but exact mechanism this regulation unknown. It established that LH stimulates receptor/choriogonadotropin receptor, a G-protein coupled to increase cAMP and activate cAMP-dependent protein kinase A (PKA). In present study, we tested hypothesis cAMP/PKA-dependent Wnt pathway components glycogen synthase (GSK)-3β β-catenin contributes LH-dependent steroidogenesis...
Background: Evidence about the associations between Cantonese dietary patterns and mortality is scarce. We examined prospective association of pattern with all-cause, cancer cardiovascular disease (CVD) in older Chinese. Methods: included 19 598 participants a Guangzhou Biobank cohort study aged 50+ years, who were recruited from 2003 to 2006 followed up until July, 2022. The diet was assessed by using 300-item validated food frequency questionnaire. items collapsed into 27 groups. Factor...
Background 'Environmental mismatch' may contribute to obesity in rapidly developing societies, because poor early life conditions could increase the risk of a subsequently more socio-economically developed environment. In recently population (from southern China) we examined association life-course socio-economic position (SEP) with obesity. Methods cross-sectional study 9998 adults from Guangzhou Biobank Cohort Study (phase 2) 2005–06, used multivariable linear regression assess SEP at...
Introduction: Ageing process is influenced by multi-dimensional factors collectively. Previous studies examined association of one separate factor with mortality without considering different manifestations ageing process. We investigated associations accelerating age (AA), a proxy to quantify ageing, in older Chinese. Methods: 9,831 participants from Guangzhou Biobank Cohort Study were included. Four exposure domains 15 variables including demographic and socio-economic factors, lifestyle...
Abstract Humans experience many influenza infections over their lives, resulting in complex and varied immunological histories. Although experimental quantitative analyses have improved our understanding of the processes defining an individual’s antibody repertoire, how these within-host are linked to population-level epidemiology remains unclear. Here, we used a multi-level mathematical model jointly infer dynamics individual-level lifetime A/H3N2 infection histories for 1,130 individuals...
Poor oral hygiene is associated with overall wellness, but evidence regarding associations of health all-cause mortality remain inconclusive. We aimed to examine the and cause-specific in middle-aged older Chinese adults.
Whether material deprivation-related childhood socio-economic disadvantages (CSD) and care-related adverse experiences (ACE) have different impacts on depressive symptoms in middle-aged older people is unclear.
H2AX is phosphorylated (γH2AX) by members of the phosphatidylinositol 3-kinase (PI3K) family, including Ataxia telangiectasia-mutated (ATM), ATM- and Rad3-related (ATR) DNA-PK in response to DNA damage. Our study shows that gossypol acetic acid (GAA) alone can induce γH2AX Human mucoepidermoid carcinoma cell line (MEC-1) vitro. Thus, we further examined possible mechanisms GAA tumor cells. The PI3K inhibitors caffeine wortmannin were used an effort identify kinase(s) responsible for -induced...
Abstract Background Currently, coronavirus disease 2019 (COVID-19) is continuously and rapidly circulating, causing heavy damage on public health. No effective antiviral treatment has been proved thus far. Traditional Chinese medicine (TCM) widely applied in the of a variety infection diseases China, hoping to produce clinical effects reduce use antibiotics glucocorticoid. The aim this study evaluate efficacy safety Shenhuang granule severe COVID-19. Methods/design This multicenter,...
In order to actively respond the severe situation of current African swine fever (ASF) epidemic, this paper proposed a double-quantitative decision rough set method over two universes. First, model universes based on compatibility relation is defined. Furthermore, characteristics ASF decision-making problems are fully considered, and process transformed into approximation problem. Then, we construct application problems. The upper lower approximations objects calculated by double...
Background: Adenylyl cyclase type 9 (ADCY9) modulates signal transduction by producing the second messenger cyclic AMP. It has been reported that ADCY9 polymorphisms were associated with cancer development. The aim of this study was to investigate whether could contribute susceptibility hepatocellular carcinoma (HCC) in Chinese. Methods: In present study, five single nucleotide (SNPs) genotyped using Agena MassARRAY platform 876 subjects from China. Logistic regression used assess effects...
Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. were subjected to 17β estradiol into lateral ventricle. Immunofluorescence double staining showed increased tyrosine hydroxylase and calbindin-D28K expression co-expression dopaminergic neurons midbrain substantia nigra pars compacta mice. Behavior...
Abstract Background Currently, coronavirus disease-2019 (COVID-19) is continuously and rapidly circulating, resulting in serious extensive effects on human health. Due to the absence of antiviral medicine for COVID-19 thus far, there a desperate need develop effective medicine. Traditional Chinese (TCM) has been widely applied treatment epidemic diseases China, with aim achieving clinical efficacy decreasing use antibiotics glucocorticoids. The this study was evaluate safety Baidu Jieduan...
<title>Abstract</title> <bold>Background:</bold>Usher syndrome (USH) is an inherited disorder characterized by sensorineural hearing loss (SNHL), retinitis pigmentosa (RP)-related vision loss, and vestibular dysfunction. USH presents itself as three distinct clinical types 1, 2 3, with no biomarker for early detection. This study aimed to explore novel microRNA (miRNA) biomarkers comparing miRNA expression patterns in cell lines derived from patients control subjects....
Usher syndrome (USH) is an inherited disorder characterized by sensorineural hearing loss (SNHL), retinitis pigmentosa (RP)-related vision loss, and vestibular dysfunction, presenting as three distinct clinical types. affects estimated 4-12 individuals in 100,000 there currently no cure for the disease. Thus, early diagnosis allows best chance education implementation of treatment strategies to mitigate symptoms. Recently, has been interest dysregulated miRNA expression potential biomarkers
Tea consumption is avoided by some due to concerns about its potential cause anemia. To clarify this impact, we assessed the association between tea intake and anemia in a Chinese prospective cohort study Mendelian randomization (MR). We analyzed associations of with using data from baseline (