A5081756289- Inflammatory Bowel Disease
- Liver Diseases and Immunity
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Immune responses and vaccinations
- Immune cells in cancer
- Diverticular Disease and Complications
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Chemokine receptors and signaling
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
Amsterdam University Medical Centers
2018-2020
University of Amsterdam
2014-2020
Amsterdam UMC Location University of Amsterdam
2014-2017
Yonsei University
2016
Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi
2016
Crohn's disease (CD) is a chronic inflammatory disorder belonging to the bowel diseases (IBD). CD affects distinct parts of gastrointestinal tract, leading symptoms including diarrhea, fever, abdominal pain, weight loss, and anemia. The aim this study was assess whether DNA methylome peripheral blood cells can be associated with in women. Samples were obtained from 18 female patients histologically confirmed ileal or ileocolic 25 healthy age- gender-matched controls (mean age standard...
Cyclosporine and infliximab (IFX) seem equally effective as rescue therapy in hospitalized patients with severe ulcerative colitis (UC), although associated hospital stay costs may differ.The aim of this study was to compare the duration from initiation time discharge corticosteroid-refractory UC receiving cyclosporine or IFX. Colectomy rates after 6 months were used outcome parameter for treatment success.Hospital records admitted between November 2003 August 2012 at a tertiary referral...
The expression of interleukin (IL)-17 is upregulated in inflammatory bowel disease (IBD). Since fibroblasts are known to be responsive IL-17, they may play a role the modulation responses IBD. Here, effects IL-17 on ileum and colon from Crohn's (CD) ulcerative colitis (UC) patients investigated, as compared controls.Fibroblasts were isolated surgical specimens taken tissue 21 CD patients, 5 UC 14 undergoing surgery for colorectal carcinoma (control). cultured with without IL-17. We performed...
Ciclosporin A [CsA] and infliximab [IFX] are similarly effective in preventing short-term colectomy ulcerative colitis [UC] patients, but long-term data scarce. We aimed to compare short- efficacy of CsA IFX by analysing rates failure remission-induction treatment as outcome parameters for success. retrospectively studied hospitalised UC patients who received or moderate-to-severe UC, between January 2000 April 2014. The primary endpoint was time colectomy, [defined another with...
Crohn’s disease (CD) is a multifactorial incurable chronic disorder. Current medical treatment seeks to induce and maintain state of remission. During episodes inflammation, monocytes infiltrate the inflamed mucosa whereupon they differentiate into macrophages with pro-inflammatory phenotype. Here, we sought characterize circulating by profiling their DNA methylome relate it level CD activity. We gathered an all-female age-matched cohort 16 patients 7 non-CD volunteers. were further...
MicroRNAs (miRNAs) are epigenetically involved in regulating gene expression. They may be of importance the pathogenesis inflammatory bowel disease (IBD). The aim this study was to determine role miRNAs by their specific blocking CD4+CB45RBhi T-cell transfer model chronic experimental colitis.Colitis caused WT CD4+CD45RBhi T cells severe combined immunodeficiency (SCID) mice shares many features with human IBD. Colonic miRNA expression levels were measured at three time points colitic mice,...
Background The chronic remitting and relapsing intestinal inflammation characteristic of Crohn's disease frequently leads to fibrosis subsequent stenosis the inflamed region. Approximately a third all patients require resection at some stage in their course. As pathogenesis associated is largely unknown, strong necessity exists better understand pathophysiology thereof. Methods In this study, we investigated changes DNA methylome transcriptome ileum-derived fibroblasts occurrence fibrosis....
Abstract Crohn’s disease (CD) is a multifactorial incurable chronic disorder. Current medical treatment seeks to induce and maintain state of remission. During episodes inflammation, monocytes infiltrate inflamed mucosa whereupon they differentiate into macrophages with pro-inflammatory phenotype. Here, we sought characterize the circulating by profiling their DNA methylome relate it level CD activity. We gathered an all-female age-matched cohort 16 patients 7 non-CD volunteers. were further...
displayed near perfect accuracy, as well sensitivity accompanied by high specificity.IL9 performance was expressed overall accuracy (area under ROC curve, AUC) independent from a threshold selection, and specificity at optimal yielding the highest Youden index.IL9 exhibited strongest association with active IBD.As its marker, IL9 were equally high.Conclusions: Our results demonstrate elevation in IBD that might be used for diagnostic purposes, assist noninvasive evaluation of mucosal healing IBD.
Background: More than one-third of Crohn's disease (CD) patients develop a fibrostenotic phenotype that can ultimately result in intestinal obstruction. The current available anti-inflammatory therapies are not sufficient to revert or treat fibrosis. Timely intervention focused on reducing fibrosis is still an unmet need CD. Continuous activation by microbial-associated molecular signatures and/or cytokines may lead altered gene expression and modulation signaling pathways via epigenetic...