A5008150044- Inflammatory Bowel Disease
- Restless Legs Syndrome Research
- Gut microbiota and health
- Microscopic Colitis
- Whipple's Disease and Interleukins
- Obstructive Sleep Apnea Research
- Eosinophilic Esophagitis
- Hepatitis B Virus Studies
- Workplace Health and Well-being
- Employment and Welfare Studies
- Thermal Radiation and Cooling Technologies
- Clinical Nutrition and Gastroenterology
- Sympathectomy and Hyperhidrosis Treatments
- Virus-based gene therapy research
- Cardiac Fibrosis and Remodeling
- Thermal properties of materials
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Probiotics and Fermented Foods
- Retirement, Disability, and Employment
- Psoriasis: Treatment and Pathogenesis
- Gastrointestinal motility and disorders
- Advanced Thermoelectric Materials and Devices
- Urticaria and Related Conditions
- Ubiquitin and proteasome pathways
Yonsei University
2010-2025
Severance Hospital
2018
Gangnam Severance Hospital
2017-2018
Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi
2016
Manganese (Mn) is widely used in many industries but also biologically harmful when abundant the environment. While there are several commercially available methods for manganese removal from water, efficient and cost-effective solutions addressing contamination diverse environmental matrices remain limited. In this study, we developed a new method removing Mn contaminated lakes using an aptamer. The Seo-Gok Reservoir was selected as study area due to its significant levels of contamination....
Enterotoxigenic Bacteroides fragilis (ETBF) is an intestinal bacterium that secretes the metalloprotease toxin (BFT), which induces E-cadherin cleavage and interleukin-8 secretion in human epithelial cell lines. ETBF-induced proposed to be underlying reason for promotion of colitis ETBF-infected mice. However, a BFT-responsive murine line has not yet been reported. In current study, we report mouse colonic CMT93 undergoes ectodomain cleavage, rounding, proliferation response BFT treatment....
Postmenopausal hyperhidrosis is a form of secondary hyperhidrosis, and hormone-replacement therapy commonly used therapeutic option. However, some women do not benefit from this treatment, oral anticholinergics are logical alternative for reducing generalized sweating in these patients. Twenty-one patients were medicated with 5 or 10 mg oxybutynin per day. After 3-month follow-up period, efficacy was assessed the Hyperhidrosis Disease Severity Scale (HDSS) Dermatology Life Quality Index...
In many countries, including South Korea, labour market changes have led to an increase in unstable, temporary jobs. There is evidence that workers such jobs may experience poorer mental health than those more stable employment.To investigate the association between employment and depressive symptoms Korean workers.We analysed data from 2010-2014 Welfare Panel Study (KOWEPS). Employment type was categorized into paid per day of (day labourers), on short-term contracts (fixed-term workers)...
The human colonic commensal enterotoxigenic Bacteroides fragilis (ETBF) is associated with chronic colitis and colon cancer. ETBF colonization induces via the toxin (BFT). BFT secreted by cause inflammation E-cadherin cleavage/NF-κB signaling. promotes tumorigenesis interleukin 17A (IL-17A)/CXCL-dependent inflammation, but its bioactive therapeutics in ETBF-promoted remain unexplored. In current study, we investigated caffeic acid phenethyl ester (CAPE) murine model of tumorigenesis. this...
displayed near perfect accuracy, as well sensitivity accompanied by high specificity.IL9 performance was expressed overall accuracy (area under ROC curve, AUC) independent from a threshold selection, and specificity at optimal yielding the highest Youden index.IL9 exhibited strongest association with active IBD.As its marker, IL9 were equally high.Conclusions: Our results demonstrate elevation in IBD that might be used for diagnostic purposes, assist noninvasive evaluation of mucosal healing IBD.
Predictors for subsequent 5-year disabling course are an age below 40 years, the initial requirement corticosteroids, and jejunal involvement in Korean patients with CD.Further prospective validation of these parameters is warranted.
100 nM (both p = 0.000).JAK3i to inhibited T-cell proliferation at 2000 (p 0.022).Conclusions: In vitro, JAK1i and tofacitinib, but not JAK3i, inhibit CXCL10 secretion produced by IFNγ/LPS triggered human monocyte-derived macrophages of T-cells in a dose-dependent manner.JAK3i inhibits higher dose, without affecting viability.
100 nM (both p = 0.000).JAK3i to inhibited T-cell proliferation at 2000 (p 0.022).Conclusions: In vitro, JAK1i and tofacitinib, but not JAK3i, inhibit CXCL10 secretion produced by IFNγ/LPS triggered human monocyte-derived macrophages of T-cells in a dose-dependent manner.JAK3i inhibits higher dose, without affecting viability.
UC: High intake of total fats, PUFA, omega-6 fatty acids, and meat were consistently associated with an increased risk developing UC.High vegetable was a decreased UC.CONCLUSIONS: dietary are CD UC, whereas high fiber fruit is UC risk.These observations suggest ' 'western' diet may increase the IBD.
Restless legs syndrome (RLS) is regarded as a common sleep disorder with significant impact on quality of life and genetic background, more frequently occurring in Caucasian than Asian population. RLS prevalence Korean adult population 3.9 - 14.3%, higher those reported other countries. A wide range derives from the differences characteristics methods to define RLS. We aimed provide estimate adults, compared previous reports Korea, western In this study, we included two independent samples...
An association between restless legs syndrome (RLS) and hypertension remains controversial. Therefore, we investigated the relationship leg in a nationwide sample of Korean adult population. This is cross-sectional questionnaire-based study including 2740 adults aged 19 years or more. A diagnosis RLS was based on International Study Group criteria those who meet four essential were categorized to have RLS. We further with into two groups according symptom frequency: frequent (≥ 2/week)...
Clinical questionnaires can be a convenient and efficient means of screening individuals at high risk obstructive sleep apnea (OSA). The Berlin questionnaire is the most widely used for OSA in clinical practice its properties have been validated several population-based studies. We determined prevalence, associated factors, health consequences Korean adult population. analyzed data from 2,740 subjects who responded to nationwide survey characteristics. Those qualified under two or more...