Our previous study demonstrated that a 5% ethanol extract of unripe Rubus coreanus (5-uRCK) has hypo-cholesterolemic and anti-obesity activity. However, the molecular mechanisms its effects are poorly characterized. We hypothesized 5-uRCK one major bioactive compounds, ellagic acid, decrease cellular plasma cholesterol levels. Thus, we investigated hypocholesterolemic activity mechanism in both hepatocytes high-cholesterol diet (HCD)-induced rat model. Cholesterol liver serum was...

(<i>R</i>)-4-(3,4-Dihydro-8,8-dimethyl)-2<i>H</i>,8<i>H</i>-benzo[1,2-<i>b</i>:3,4-<i>b</i>′] dipyran-3yl)-1,3-benzenediol (glabridin) is known to have anti-inflammatory, antimicrobial, and cardiovascular protective activities. In the present study, we report inhibitory effect of glabridin on intercellular adhesion molecule-1 (ICAM-1) expression in tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs). Glabridin inhibited THP-1 cell HUVECs stimulated by...

Glabridin, a flavonoid present in licorice root, is known to have antiinflammatory and cardiovascular protective activities. The study reports an inhibitory effect of glabridin on microglial activation. Glabridin dose-dependently attenuated lipopolysaccharide (LPS)-induced production inflammatory mediators, including nitric oxide, tumor necrosis factor-alpha interleukin-1beta, BV-2 cells, murine microglia cell line. Moreover, mRNA expression these mediators was also suppressed by...

We investigated the time-dependent deleterious ocular changes induced by urban particulate matter (UPM) in vitro and vivo. UPM treatment decreased human corneal epithelial cell migration survival. Fluorescein scores were consistently increased application for 16 weeks. One week of rest at 2 or 4 weeks led to a recovery trend, whereas two 8 no change. tear film break-up time weeks, which was thereafter maintained until No found after periods rest. UPM-treated eyes exhibited greater epithelium...

Previously, we demonstrated that a 5% ethanol extract of unripe Rubus coreanus (5-uRCK) and ellagic acid has hypocholesterolemic antiobesity activity, at least partially mediated by the downregulation adipogenic lipogenic gene expression in high-fat diet (HFD)-fed animals. The present study investigated thermogenic lipolytic effects 5-uRCK HFD-induced obese C57BL/6 mice explored its mechanism action. Mice fed an HFD received or as post-treatment pretreatment. Both post-treated pretreated...

Blue light is reported to be harmful eyes by inducing reactive oxygen species (ROS). Herein, the roles of Peucedanum japonicum Thunb. leaf extract (PJE) in corneal wound healing under blue irradiation are investigated. Blue-light-irradiated human epithelial cells (HCECs) show increased intracellular ROS levels and delayed without a change survival, these effects reversed PJE treatment. In acute toxicity tests, single oral administration (5000 mg/kg) does not induce any signs clinical or body...

In this study, we carried out a comparative evaluation of antiaging and anti-melanogenesis activities raspberry extracts (Rubus occidentalis L.) according to their stage ripening (uRo: unripe raspberry, Ro: ripe raspberry), analyzed the active component (ellagic acid) present in these extracts. Our results showed higher inhibitory effects uRo extract terms elastase collagenase than Ro extract. CCD-986sk cells, significantly inhibited MMP-1 activity by 18% increased rate type 1 pro-collagen...

We previously demonstrated that urban particulate matter (UPM) exposure decreases the migration activity and survival of human corneal epithelial cells (HCECs). Herein, we investigated potential to improve wound-healing ability

Recently, many studies have reported the properties and functionality of okra pectin. However, these are about green pods, pectin in red stems, roots has not been reported. Therefore, this study aimed to optimize extraction method using response surface methodology (RSM) analysis evaluate effects time, temperature, solvent ratio, pH on extract yield crude content. Based RSM analysis, 4.35 h, 98.04 °C, 23.34 3.36 optimal parameters for extracting from okra, content was predicted be 40.83%....

The goal of this study was to investigate the extracts ellagic acid in Korean and Chinese black raspberries according harvest time extraction solvent. This also performed establish a simple reliable high-performance liquid chromatography-ultraviolet (HPLC/UV) analytical method for determination quality control baseline data Rubus occidentalis (uRo) chingii (uRc) fruits as healthy functional food ingredients. uRo uRc were each extracted with 0%, 5%, 30%, 70% ethanol. Among these two...

Abstract Background Many clinical trials on antihypertensive drugs have confirmed the usefulness of these in regulating blood pressure effectively. However, all usually require long-term use; thus, economic burdens as well some adverse effects, including headache, diarrhea, skin rash, edema, fever, and liver kidney dysfunction, accompany their use. Therefore, we attempted to identify natural medications for treating hypertension. We investigated effects Dendropanax morbiferus H. Lév. extract...

Dendropanax morbifera Lev. (DP) leaves have the potential for use as a functional food ingredient. In this study, D. were subjected to enzymatic hydrolysis by proteinase, peptidase, trypsin, bromelain, and papain increase L-arginine γ-aminobutyric acid (GABA) levels. Hydrolysis time, temperature, pH, vacuum conditions, enzyme type, concentration, order of administration optimized GABA concentrations. recoveries higher when treatment was performed prior extraction process. No significant...

Background and Objectives: This study aimed at investigating the laxative effects of a standardized aqueous extract Dendropanax morbiferus H. Lév. on two different constipation rat models. Materials Methods: Animal studies were conducted with low-fiber diet-induced loperamide-induced animal models, isolated colons used in ex vivo analysis to determine changes colonic motility caused by D. leaf (DPL). Results: The results showed that DPL administration significantly improved certain reduced...

Dendropanax morbifera Leveille (Araliaceae) is an endemic species growing in the south-western part of South Korea that has been used folk medicine and health functional food. In this study, we investigated extract quercetin Jeju D. by varying different parts (fruit, sprouts, leaves, sprigs, branches), harvest times, extraction solvents. addition, aimed to establish a simple reliable HPLC/UV analytical method determination for quality control base line data as food ingredient. The...

In this study, we focused on reducing the molecular weight of purified red okra pectin using various hydrolytic enzymes and evaluating its physicochemical properties or characterization. The enzyme treatments targeted both main chain side-chain sugars, resulting in a reduction by approximately 10% (from 647 kDa) to 60% (down 252 kDa). Both enzyme-treated pectins exhibited homogalacturonan (HG)-type backbone. Fourier transform infrared (FT-IR) spectroscopy revealed decrease absorbance peak...

This study investigates traditional knowledge of plants used for river fishing in local communities North Jeolla Province, Korea. Data were collected using the participatory rural appraisal method based on interviews, informal meetings, open and group discussions, overt observations with semi-structured questionnaires. Field investigations conducted at 19 sites from July 2008 to April 2010. Interviews included 37 key informants (16 men 21 women) who lived more than 50 years area. The average...

Previously, we demonstrated that the specific ratio of Korean multi-herbal formula (SR-5) exhibits hepatoprotective properties against ethanol-induced hepatic damage in rats. Chronic and excessive alcohol consumption is a major etiological factor involved gastric disease ulcer development induced by inflammatory response oxidative stress.The present study evaluated gastroprotective effects SR-5 (100, 150, 200 mg/kg) hydrochloride acid/ethanol (HCl/EtOH)-induced indomethacin/hydrochloride...

Abstract Glabridin, a flavonoid present in licorice root, is known to have anti-inflammatory and cardiovascular protective activities. In the study, we report an inhibitory effect of glabridin on microglial activation. Glabridin dose-dependently attenuated lipopolysaccharide (LPS)-induced production inflammatory mediators, including nitric oxide, tumor necrosis factor-α interleukin-1β, BV-2 cells, murine microglia cell line. Moreover, mRNA expression these mediators was also suppressed by...