A5022511974- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Cancer Immunotherapy and Biomarkers
- Heat shock proteins research
- Angiogenesis and VEGF in Cancer
- Single-cell and spatial transcriptomics
- Parathyroid Disorders and Treatments
- Lung Cancer Treatments and Mutations
- FOXO transcription factor regulation
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Brain Metastases and Treatment
- Plant and Fungal Interactions Research
- Nuclear Receptors and Signaling
- Cancer Mechanisms and Therapy
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Bone health and treatments
New York University
2018-2024
Memorial Sloan Kettering Cancer Center
2024
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2018-2024
NYU Langone Health
2017
Vanderbilt University
2013-2015
VA Tennessee Valley Healthcare System
2014
United States Department of Veterans Affairs
2014
Highly coordinated changes in gene expression underlie T cell activation and exhaustion. However, the mechanisms by which such programs are regulated how these may be targeted for therapeutic benefit remain poorly understood. Here, we comprehensively profile genomic occupancy of mSWI/SNF chromatin remodeling complexes throughout acute chronic stimulation, finding that stepwise localization over transcription factor binding sites direct site-specific accessibility leading to distinct...
Stromal cells in the tumor microenvironment play a key role metastatic properties of tumor. It is recognized that cancer-associated fibroblasts (CAFs) and endothelial secrete factors capable influencing cell migration into blood or lymphatic vessels. We developed microfluidic device can be used to image interactions between stromal spheroids three dimensional (3D) while enabling external control interstitial flow at an interface, which supports cells. The apparatus couples 200-μm channel...
Abstract Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells inhibited, up to complete rejection, in Siah2 −/− mice. Growth-inhibited tumors exhibit increased numbers intra-tumoral activated T and decreased expression Ccl17, Ccl22 , Foxp3 . Marked reduction Treg proliferation tumor infiltration coincide with G1 arrest infiltrated Tregs vivo or following cell stimulation...
Abstract Melanoma being one of the most common and deadliest skin cancers, has been rising since past decade. Patients at advanced stages disease have very poor prognoses, as opposed to earlier stages. Nowadays standard-of-care melanoma is resection followed by immune checkpoint inhibition based immunotherapy. However, a substantial proportion patients either do not respond or develop resistances. This underscores need for novel approaches therapeutic targets well better understanding...
The incidence of melanoma, being one the most commonly occurring cancers, has been rising since past decade. Patients at advanced stages disease have very poor prognoses, as opposed to earlier stages. conventional targeted therapy is well defined and effective for advanced-stage melanomas patients not responding standard-of-care immunotherapy. However, therapies do prove be inevitably develop V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF)-inhibitor resistance respective drugs. Factors...
Abstract T cell activation and exhaustion are associated with highly coordinated changes in gene expression chromatin accessibility. While the contribution of key, state-specific transcription factors to these processes has been extensively explored, role for regulatory complexes remains less clear. The mammalian SWI/SNF (mSWI/SNF) a diverse family ATP-dependent remodeling that regulate DNA accessibility hence facilitate timely appropriate expression. Recent genome-scale CRISPR screens have...
Abstract As recent decades have seen extensive resources dedicated to exploring tumor metastasis, discoveries exposed a need for understanding the intricacies of microenvironment (TME) in an ex vivo model. Much heterogeneity disease stems from complexity interactions between cells that comprise TME, placing its investigation at heart developing effective treatment. A number findings implicate chemokines and their receptors, expressed early cancer progression, promoting metastasis. These...