A5078821560- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Pharmacological Effects of Natural Compounds
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Heat shock proteins research
- Erythrocyte Function and Pathophysiology
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Nerve injury and regeneration
- Stress Responses and Cortisol
- Endoplasmic Reticulum Stress and Disease
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
New York University
2021-2024
Columbia University Irving Medical Center
2023
Allen Institute for Brain Science
2017-2020
Icahn School of Medicine at Mount Sinai
2017-2020
University of Crete
2019
Neuropathic pain is a complex chronic condition characterized by various sensory, cognitive, and affective symptoms. A large percentage of patients with neuropathic are also afflicted depression anxiety disorders, pattern that seen in animal models. Furthermore, clinical preclinical studies indicate corresponds adaptations several brain networks involved mood, motivation, reward. Chronic stress major risk factor for depression. We investigated whether affect similar molecular mechanisms can...
Regulator of G-protein signaling 4 (RGS4) is a potent modulator G-protein-coupled receptor signal transduction that expressed throughout the pain matrix. Here, we use genetic mouse models to demonstrate role RGS4 in maintenance chronic states male and female mice. Using paradigms peripheral inflammation nerve injury, show prevention action leads recovery from mechanical cold allodynia increases motivation for wheel running. Similarly, RGS4KO eliminates duration nocifensive behavior second...