A5026288210- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Magnetism in coordination complexes
- Metal complexes synthesis and properties
- Metal-Organic Frameworks: Synthesis and Applications
- Crystallography and molecular interactions
- Lanthanide and Transition Metal Complexes
- Organometallic Complex Synthesis and Catalysis
- Molecular spectroscopy and chirality
- thermodynamics and calorimetric analyses
- Advanced NMR Techniques and Applications
- Analytical Chemistry and Chromatography
- Lipid Membrane Structure and Behavior
- Protein Structure and Dynamics
- Free Radicals and Antioxidants
- Synthesis and Characterization of Heterocyclic Compounds
- Enzyme Structure and Function
- Biopolymer Synthesis and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Advanced MRI Techniques and Applications
- Ferrocene Chemistry and Applications
- Hemoglobin structure and function
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Amino Acid Enzymes and Metabolism
Universidad Complutense de Madrid
1996-2024
Institut de Chimie de la Matière Condensée de Bordeaux
2017-2024
Université de Bordeaux
2017-2021
Centre National de la Recherche Scientifique
2017-2021
Paul Pascal Research Center
2017-2021
Center for Research in Psychopathology and Clinical Psychology
2018-2021
Institut Polytechnique de Bordeaux
2017-2020
Centre d’Élaboration de Matériaux et d’Études Structurales
2017-2019
European Synchrotron Radiation Facility
2018
Université de Toulouse
2017
Hyperpolarised gases have been most recently used in magnetic resonance imaging to demonstrate new image-derived pulmonary function parameters. One of these parameters is the apparent diffusion coefficient, which reflects sizes structures that compartmentalise gas within lung ( i.e. alveolar space). In present study, noninvasive were compared microscopic measurements (mean linear intercept and mean internal area). Nonselective helium‐3 density coronal ex vivo images maps acquired control...
We report the preparation of a helical complex and its study in molecular junctions. show that SAMs this racemic compound present an electrically robust behaviour which will...
Abstract— The fluorescent probe Prodan (6‐propionyl‐2‐dimethyl‐aminonaphthalene) binds with high affinity to human serum albumin (HSA). spectral characteristics of the bound protein are very different from free in solution. These differences allowed spectra be deconvoluted into log‐normal bands order quantify and unbound ligand calculate binding constant at temperatures. From such temperature dependence, we found exothermic a van't Hoff enthalpy ‐22.8 kJ mol ‐1 . Thermodynamic analysis...
Chromium(II)-based extended metal atom chains have been the focus of considerable discussion regarding their symmetric versus unsymmetric structure and magnetism. We now investigated four complexes this class, namely, [Cr
The circular dichroism of a series disulphide‐free proteins in 6 M guanidine hydrochloride was measured. Despite qualitative similarity, the quantitative spread molar residue ellipticities considerable, and not explicable terms side chain chromophore contributions. It seems likely that composition‐dependence distribution backbone dihedral angles is responsible for variation. Chains with intact disulphide bonds have larger negative ellipticities. In case insulin, evidence given to suggest...
Drug resistance, one of the main drawbacks in cancer chemotherapy, can be tackled by employing a combination drugs that target different biological processes cell, enhancing therapeutic efficacy. Herein, we report synthesis and characterization new paddlewheel diruthenium complex includes 5-fluorouracil (5-FU), commonly used anticancer drug. This drug was functionalized with carboxylate group to take advantage previously demonstrated release capacity ligands from core. The resulting...
The union between magnetism and chirality is finally validated.
The study of the release carboxylate ligands from diruthenium compounds is crucial for designing drug delivery systems based on such complexes. influence different key parameters process was evaluated through in vivo assays.
The thermal denaturation of bovine β‐lactoglobulin B was investigated by high‐sensitivity differential scanning microcalorimetry between pH 1.5 and 3.0 in 2OmM phosphate buffer. process found to be a reversible, two‐state transition. Progressive addition guanidine hydrochloride at leads the appearance low‐temperature calorimetric endotherm, corresponding cold renaturation protein. Circular dichroism experiments have confirmed low high temperature processes, shown some structural differences...
The dependence of nonlinear optical properties upon the spin state in molecular switches is still an unexplored area. Chiral [Fe( phen)3]2+ complexes are excellent candidates for those studies because they expected to show interest and at same time photoconversion a short-lived metastable high-Spin by ultrafast pumping. Herein, we present synthesis, crystallographic, spectroscopic comparison chiral obtained with anions, new lipophilic derivative D2-symmetric (As2(tartrate)2)2-, D3-symmetric...
Abstract The macroscopic deprotonation constants of phenol, pyridine, p-nitrophenol, salicylaldehyde, 4-pyridinaldehyde, pyridoxine, 3-hydroxypyridine, 5-deoxypyridoxal, pyridoxal, and pyridoxal 5'-phosphate have been determined at 25 degrees C in water/dioxane mixtures. Many the hydration tautomeric microscopic pK values these compounds also measured under same conditions. These are discussed with reference to Hammett's Marshall's equations a general equation that predicts equilibrium media...
Five tris(β-diketonato) complexes of ruthenium(III), chromium(III), and cobalt(III) [Ru(Buacac)3 (1), Ru(Oacac)3 (2), Cr(Buacac)3 (3), Cr(Oacac)3 (4), Co(Buacac)3 (5), where Buacac = 3-butylpentane-2,4-dionato Oacac 3-octylpentane-2,4-dionato] with a chiral propeller-like structure have been prepared. Ligands syntheses are presented together characterization the compounds by 1H 13C NMR spectroscopy, mass spectrometry, IR, UV-vis, electronic circular dichroism (ECD) electrochemistry studies,...
Abstract Several metal–organic frameworks of nickel(II) were obtained starting from the molecular complex 1 , [Ni(OH 2 ) 4 (4‐pyc) ] (4‐pyc = 4‐pyridinecarboxylate or isonicotinate). By using different reaction conditions, two polymorphs anhydrous [Ni(4‐pyc) n ( 2a and 2b polynuclear compound [Ni 5 (OH 3 10 in very high yield. All compounds characterized by elemental analysis spectroscopic data. The crystal structure determination was also carried out. Structural topological these new...
Reaction microcalorimetry and equilibrium dialysis have been used to study the binding of AMP IMP glycogen phosphorylase b (EC 2.4.1.1)at 25 "C pH 6.9.The combination both techniques has enabled us obtain some thermodynamic parameters for these processes.Four sites were found be present in dimeric active enzyme IMP.The two high-affinity sites, which, our opinion, correspond activator seems co- operative.The low-affinity which would then inhibitor appear independent when nucleotides bind...
Abstract In this paper two points are considered: the methods of evaluating helical content θ and calculation parameters transition from experimental data its interpretation. The parameter Δ H obtained is in good agreement with calorimetric one v found to be independent temperature solvent ordinarily accepted value for poly(γ‐benzyl‐ L ‐glutamate). different estimating discussed both polypeptides.
A series of 2-D nickel compounds with the stoichiometry [NiCl2(N–N)] has been prepared, [N–N = pyrazine (1), 4,4′-bipyridine (2), trans-4,4′-azopyridine (3), trans-1,2-bis(4-pyridyl)ethylene (4), and 1,2-bis(4-pyridyl)ethane (5)]. The complex [NiBr2(4,4′-bpy)] (6) was also obtained for comparative reasons. Compound 2 is β phase previously reported [NiCl2(4,4′-bpy)]. syntheses complexes 1–6 were carried out using solvothermal microwave techniques. have characterized by elemental analysis,...
Enantiopure single crystals of extended metal atom chains display exceptionally large optical X-ray dichroisms at the Co K-edge.
The complete series of [Ru2Cl(Dp-FPhF)x(O2CCH3)4-x] (x = 1-4; Dp-FPhF- N,N'-bis(4-fluorophenyl)formamidinate) compounds, has been prepared and characterized by a multi-technique approach, including single crystal X-ray diffraction. A careful study the different methodologies allowed us to prepare four compounds with good yields without an inert atmosphere or further purification. Specifically, [Ru2Cl(Dp-FPhF)(O2CCH3)3] (1) was obtained using ultrasound-assisted (USS) method, while...