A5110129641- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Biliary and Gastrointestinal Fistulas
- Leptospirosis research and findings
- Pediatric Hepatobiliary Diseases and Treatments
- Antifungal resistance and susceptibility
- Case Reports on Hematomas
- Synthesis and Characterization of Pyrroles
- Cancer therapeutics and mechanisms
- Chemical Synthesis and Analysis
- Congenital Diaphragmatic Hernia Studies
- Marine Sponges and Natural Products
- Bacterial Identification and Susceptibility Testing
- Gallbladder and Bile Duct Disorders
- Synthetic Organic Chemistry Methods
- Respiratory Support and Mechanisms
- Streptococcal Infections and Treatments
- Vasculitis and related conditions
- Yeasts and Rust Fungi Studies
- Peripheral Nerve Disorders
- Proteoglycans and glycosaminoglycans research
- Liver Disease and Transplantation
- Cell Adhesion Molecules Research
- Fungal and yeast genetics research
- Nitrogen and Sulfur Effects on Brassica
Instituto Canario de Ciencias Marinas
2006
Hospital Universitario Nuestra Señora de Candelaria
2002-2006
Centro de Investigaciones Biológicas Margarita Salas
2006
Canary Institute of Cancer Research
2003
Hospital San Pedro de Alcántara
2000
Background: Mixed trial results suggest that some ventilated patients with acute respiratory distress syndrome (ARDS) benefit from high PEEP while others may be harmed, indicating heterogeneity of treatment effect (HTE). This study applies data-driven predictive approaches to uncover HTE and re-examines previously hypothesized HTE. manuscript serves as a pre-registration planned external validation our trained models. Methods: We identified eight randomized trials, obtained individual...
Abstract A series of functionalized tetrahydropyran and dihydropyran derivatives was synthesized by means a Prins‐type cyclization between unsaturated alcohols several aldehydes. An unprecedented dimer bearing two 4‐chloro‐5,6‐dihydro‐2 H ‐pyran scaffolds obtained in high yield. panel three representative human solid tumor cells from diverse origin used to assess the cytotoxicity compounds. Overall, results show relevance chlorovinyl group biological activity, 2‐alkyl‐4‐chloro‐5,6‐dihydro‐2...
Abstract Interleukin‐1β (IL‐1β) mediates destruction of matrix collagens in diverse inflammatory diseases including arthritis, periodontitis, and pulmonary fibrosis by activating fibroblasts, cells that interact with proteins through integrin‐based adhesions. In vitro, IL‐1β signaling is modulated focal adhesions, supramolecular protein complexes are enriched tyrosine kinases phosphatases. We assessed the importance phosphatases regulating cell–matrix interactions signaling. human gingival...
Abstract A short and efficient enantiomeric synthesis of fused tetrahydrofuran derivatives is reported. The methodology based on a regio‐ stereoselective double exo ‐cyclization bis‐epoxy‐diols. six stereocenters the bis‐epoxy diols were introduced by application Katsuki–Sharpless asymmetric epoxidation Sharpless dihydroxylation reactions. In vitro cytotoxicities HL60 human promyelocytic leukemia cells determined for bicyclic products. Active products showed exceptionally steep dose–response...
A series of tetrasubstituted pyrrole derivatives, structurally related to tyrosine kinase inhibitors, has been synthesized one-pot by irradiation a silica gel absorbed mixture conjugated alkynoate and primary amine. The compounds were evaluated for their anticancer activities using the human breast cancer cell lines, T-47D MCF7. Keywords: Pyrroles, diversity-oriented synthesis, privileged structure, cancer, SU11248, inhibitors