A5000018308- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Electrochemical sensors and biosensors
- Diamond and Carbon-based Materials Research
- Laser-Ablation Synthesis of Nanoparticles
- Neuroscience and Neuropharmacology Research
- Education and Work Dynamics
- Nanoplatforms for cancer theranostics
- Nonlinear Optical Materials Studies
- HIV/AIDS Research and Interventions
- Advanced Biosensing Techniques and Applications
- Ion channel regulation and function
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Coordination Chemistry and Organometallics
- MXene and MAX Phase Materials
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Crystallization and Solubility Studies
- Molecular Sensors and Ion Detection
- Treatment of Major Depression
- Synthesis and properties of polymers
- HIV Research and Treatment
- GABA and Rice Research
Sun Yat-sen University
2017-2020
Ningxia Academy of Social Sciences
2012
AstraZeneca (United States)
2008-2011
Wilmington University
1998-2000
Experimental Station
2000
DuPont (United States)
1998-2000
The enzymatic antioxidant system (EAS) protects aerobic cells from oxidative stress. However, it is brittle and susceptible of inactivation reactive oxygen species (ROS) immoderate production. Here, we demonstrated that MoS2 nanosheets (few-layer MoS2), as a multifunctional nanozyme, possess intrinsic activity mimicking enzymes superoxide dismutases (SODs), catalases (CATs), peroxidases (PODs) under physiological conditions (pH 7.4, 25 °C). Further, showed POD-like by transferring electrons...
Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate maintain intracellular levels at an appropriate low level. The deficiency SuOx would cause severe neurological damage and infant diseases, which makes tremendous biomedical importance. Herein, mimic nanozyme PEGylated (polyethylene glycol)-MoO3-x nanoparticles (P-MoO3-x NPs) with abundant oxygen vacancies created by vacancy-engineering reported. Their level -like activity 12 times...
Ti<sub>3</sub>C<sub>2</sub> nanosheets possess intrinsic peroxidase-like activity and are applied to colorimetric detection immunoassay.
MoSe<sub>2</sub> nanosheets possess intrinsic peroxidase-like activity and are applied to H<sub>2</sub>O<sub>2</sub> xanthine detection with high sensitivity selectivity.
Intraarticular injection of hyaluronic acid (HA) for viscosupplementation is a nonsurgical therapy osteoarthritis (OA). However, HA fails to lubricate under significant load and tends be depolymerized by the overproduction reactive oxygen species (ROS) in inflammation. Here, we first time reported that fullerene-like MoS2 (F-MoS2) nanoparticles are efficient lubricants antioxidants artificial synovial fluid. A model arthrosis was built, evaluate tribological behavior F-MoS2 nanoparticles....
Combinatorial chemistry has opened a new realm of chemical entities in the search for novel therapeutics. is currently adding hundreds thousands compounds to similar numbers available from years synthesis by medicinal chemistry. It not unreasonable expect that over next several years, nearly million will be screening against each therapeutic target. The number potential targets also increasing with advances genomics. With screened an targets, it becoming increasingly difficult and costly...
Local surface plasmon resonance (LSPR)-enhanced catalysis has brought a substantial amount of opportunities across various disciplines such as photocatalysis, photodetection, and photothermal therapeutics. Plasmon-induced hot carriers effects have also been utilized to activate the enzyme-like reactions. Compared with natural enzymes, relatively low catalytic performance nanozymes severely hampered potential applications in field biomedicine. For these issues mentioned above, herein, we...
The ionotropic γ-aminobutyric acid (GABA)A receptors are an important family of drug targets for a variety neurological and psychiatric disorders. Selective modulation certain subtypes the receptor could lead to novel or improved therapies. However, discovery subtype-selective compounds has been hampered by lack high-throughput functional assay difficulty in establishing stable cell lines expressing GABAA proper subunit composition. To meet need we developed fluorescent imaging plate reader...
Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception. By random screening of our corporate compound collection with a ligand binding assay, we discovered (<i>R</i>)-5′-(phenylaminocarbonylamino)spiro[1-azabicyclo[2.2.2]octane-3,2′(3′<i>H</i>)-furo[2,3-<i>b</i>]pyridine] (R-PSOP), highly potent selective antagonist. R-PSOP is nonpeptidic...
The fabrication of inorganic fullerene-like nanoparticles (IFNPs) is an attractive idea due to their unique structures and various potential applications. To date, IFNPs have been made from numerous compounds with layered two-dimensional structures, based on synthetic methods. Here we demonstrated for the first time that molybdenum selenide (MoSe2 IFNPs) can be synthesized by laser ablating a target in 30 vol % ethanol/water mixture at ambient temperature pressure. formation mechanism was...
A mass spectrometric strategy for the direct determination of structures compounds on active beads selected from combinatorial mixtures by ultrahigh throughput screening is presented. Complementary data (exact and MS/MS spectra) were obtained in a single acquisition using automatic function switching. Analyses these produced unequivocal identifications structure 70% cases. The computer analyses generated definitve solutions 80% analyses. remainder contained components or not enumerated...
A variety of techniques exist for synthesizing nanodiamonds. However, it is challenging to produce nanoparticles with a size smaller than 4 nm without aggregation and large volumes colloidal solutions containing single-digit In this study, we demonstrate facile top-down strategy the fabrication monodisperse fluorescent nanodiamonds mean 3.6 from suspension commercial high-pressure high-temperature diamond microcrystals (raw industrial materials) in an ambient environment using laser ablation...
We for the first time reported that tantalum carbide nanoparticles (TCNPs) synthesized by a one-step laser ablation method are suitable probes CT imaging.