A5048503833- Metabolomics and Mass Spectrometry Studies
- Forensic Toxicology and Drug Analysis
- Advanced Chemical Sensor Technologies
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Alcohol Consumption and Health Effects
- Cannabis and Cannabinoid Research
- Data Mining Algorithms and Applications
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Effects and risks of endocrine disrupting chemicals
- Nanoparticle-Based Drug Delivery
- Consumer Attitudes and Food Labeling
- Tryptophan and brain disorders
- Biomedical Text Mining and Ontologies
- Inflammatory mediators and NSAID effects
- Nanoparticles: synthesis and applications
- Climate Change and Health Impacts
- Gene expression and cancer classification
- Pharmacological Receptor Mechanisms and Effects
- Global Health Care Issues
Universidade do Porto
2016-2025
Rede de Química e Tecnologia
2016-2025
Hospital Vila Franca de Xira
2024
Institute for Health Metrics and Evaluation
2024
University of Washington
2024
Universidade Federal do Ceará
2018-2024
University of Aveiro
2023
Fundação Oswaldo Cruz
2014-2015
Gold nanoparticles (AuNPs) are highly attractive for biomedical applications. Therefore, several in vitro and vivo studies have addressed their safety evaluation. Nevertheless, there is a lack of knowledge regarding potential detrimental effect on human kidney. To evaluate this effect, AuNPs with different sizes (13 nm 60 nm), shapes (spheres stars), coated 11-mercaptoundecanoic acid (MUA) or sodium citrate, were synthesized, characterized, toxicological effects evaluated 24 h after...
Serum prostate-specific antigen (PSA) is currently the most used biomarker in clinical practice for prostate cancer (PCa) detection. However, this has several drawbacks. In work, an untargeted gas chromatography-mass spectrometry (GC-MS)-based metabolomic profiling of PCa cells was performed to prove concept that metabolic alterations might differentiate cell lines from normal line. For that, we assessed differences volatile organic compounds (VOCs) profile extracellular medium...
The use of cathinone designer drugs in recreational settings has been associated with severe toxic effects, including liver damage. precise mechanisms by which cathinones induce hepatotoxicity and whether they act common pathways remain to be elucidated. Herein, we assessed the toxicity methylone, pentedrone, 3,4-methylenedioxypyrovalerone (MDPV) 4-methylethcathinone (4-MEC) primary rat hepatocytes (PRH) HepaRG cells, compared that 3,4-methylenedioxymethamphetamine (MDMA). MDPV pentedrone...
Prostate cancer (PCa) is an important health problem worldwide. Diagnosis and management of PCa very complex because the detection serum prostate specific antigen (PSA) has several drawbacks. Metabolomics brings promise for biomarker discovery better understanding biochemistry. In this study, a gas chromatography-mass spectrometry (GC-MS) based metabolomic profiling cell lines was performed. The include 22RV1 LNCaP from with androgen receptor (AR) expression, DU145 PC3 (which lack AR...
Previous studies have shown that metabolomics can be a useful tool to better understand the mechanisms of carcinogenesis; however, alterations in biochemical pathways lead bladder cancer (BC) development hitherto not been fully investigated. In this study, gas chromatography-mass spectrometry (GC-MS)-based was applied unveil metabolic between low-grade and high-grade BC cultured cell lines. Multivariable analysis revealed panel metabolites responsible for separation two tumorigenic...
Consumers are regularly exposed to well-known food contaminants (FCs), which typically assessed for risk on an individual basis. However, there is limited knowledge about the overall levels and combinations of these compounds depending dietary choices. The goal this study was estimate real-life mixtures FCs in different models by integrating extensive data from scientific literature concerning reliable quantification foods. A FAIR database detailing occurrence 73 16 foods commonly consumed...
The widespread recreational use of synthetic cannabinoids (SCBs) represents a major public health issue, as reports intoxications and deaths following SCB rapidly mount up. Specifically, direct link between acute kidney injury (AKI) has been established, although the pathophysiologic mechanisms remain undefined. Here we assessed in vitro nephrotoxicity 3 commonly detected structurally distinct SCBs—AB-FUBINACA, JWH-122, THJ-2201—in human proximal tubule cells (HK-2), to ascertain potential...
Gold nanoparticles (AuNPs) are promising nanoplatforms for drug therapy, diagnostic and imaging. However, biological comparison studies different types of AuNPs fail in consistency due to the lack sensitive methods detect subtle differences expression toxicity. Therefore, innovative approaches such as metabolomics much needed discriminate toxicity, specially at low doses. The current work aims compare vivo toxicological effects gold nanospheres versus nanostars (of similar ~40 nm diameter...