A5042415509- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Proteoglycans and glycosaminoglycans research
- Immunotherapy and Immune Responses
- Nerve injury and regeneration
- Cytokine Signaling Pathways and Interactions
- HIV/AIDS drug development and treatment
- Chronic Lymphocytic Leukemia Research
- Gut microbiota and health
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
- Signaling Pathways in Disease
- Nosocomial Infections in ICU
- HIV/AIDS Research and Interventions
- Systemic Lupus Erythematosus Research
- Infectious Encephalopathies and Encephalitis
- Multiple Sclerosis Research Studies
- Protease and Inhibitor Mechanisms
- RNA regulation and disease
University of Calgary
2011-2023
Bionomics (Australia)
2023
University of Manitoba
2019
Toronto Liver Centre
2019
Janssen (Belgium)
2019
University of Toronto
2019
McGill University
2019
Public Health Agency of Canada
2019
Vancouver Infectious Diseases Centre
2019
Conway School of Landscape Design
2019
Abstract Objective: Failure of remyelination is a critical impediment to recovery in multiple sclerosis (MS). Chondroitin sulfate proteoglycans (CSPGs) have been reported accumulate MS lesions, and we thus examined the functional roles CSPGs on oligodendrocyte precursor cells (OPCs), oligodendrocytes, remyelination. Methods: We evaluated expression lysolecithin‐injected mouse spinal cord, an animal model demyelination spontaneous The impact OPCs was investigated using cultured adult murine...
Chemokines are essential for homeostasis and activation of the immune system. The chemokine ligand/receptor pairing CCL20/CCR6 is interesting because these molecules display characteristics both homeostatic functions. These dual suggest a role CCR6 in priming effector phases response. However, while has been implicated phase several models, less clear. Herein we analyze two important arms response during experimental autoimmune encephalomyelitis (EAE). Both its ligand CCL20 were up-regulated...
Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In this study, we have investigated the role of CXCR3 CXCR4 in activation T lymphocytes their migration to central nervous system (CNS) using novel mutant chemokines antagonize specifically. A series truncation mutants CXCL11, which has highest affinity for CXCR3, were synthesized, an antagonist, CXCL11((4-79)), was obtained. CXCL11((4-79)) strongly inhibited activated mouse cells response all three...
<title>Abstract</title> There is growing evidence that differences exist in the gut microbiota of patients with Parkinson’s Disease (PD) compared health controls, and so treatment Faecal Microbiota Transplantation (FMT) may provide a novel approach towards altering disease progression response to treatment. We performed pilot study looking at safety tolerability FMT, its effect on microbiome, improvement symptoms PD. This was an open label wherein 12 mild moderate PD were administered FMT...
Abstract Background The composition of the gut microbiota both prior to and after haematopoietic stem cell transplantation (HSCT) is increasingly implicated in outcomes HSCT, including infections, poor immune reconstitution disease relapse. Faecal (FMT) offers a potential strategy supporting improve HSCT outcomes. Although FMT has been investigated recipients, it largely evaluated therapeutically for indications such as infection, or once immunocompetency regained. Methods Peri-HSCT (i.e....
Susceptibility-weighted imaging (SWI) is an iron-sensitive magnetic resonance (MRI) method that has shown iron-related lesions in multiple sclerosis (MS) patients. The contribution of deoxyhemoglobin to the signals seen SWI not been well characterized MS.To determine if (seen as focal hypointensities) exist experimental autoimmune encephalomyelitis (EAE) animal model MS, and whether relate iron deposits, inflammation, demyelination, and/or vasculature.We performed on lumbar spinal cord...
Tenofovir alafenamide fumarate (TAF) has high plasma stability resulting in fewer renal adverse events compared to tenofovir disoproxil (TDF) chronic hepatitis B (CHB) patients. We aimed study the effectiveness and safety of TAF a real-world setting, patients with or without compromised kidney function. CHB (Nucleos(t)ide Analogue [NA]-naïve experienced) who received >1 year from 11 academic institutions as part Canadian Hepatitis Network (CanHepB) were included. Kidney function was measured...
•There was ∼5% HDV seroprevalence in Canadian HBsAg-positive referred patients.•HDV genotypes 1, 2, and 5–7 were observed patients.•HDV+ patients more likely to be born Canada, White or Black/African/Caribbean.•HDV highly associated with high-risk activities (sexual intravenous drug use).•HDV+ diagnosed cirrhosis liver cancer. Background & AimsHDV affects 4.5–13% of chronic hepatitis B (CHB) globally, yet the prevalence infection Canada is unknown. To investigate prevalence, genotype,...
Published Canadian epidemiologic data on hepatitis B virus (HBV) infection include single-centre studies or are focused Indigenous populations. We performed a study to characterize the demographic and clinical features, liver disease status treatment of people with chronic in Canada.In this descriptive, opportunistic, cross-sectional study, available for known be monoinfected HBV were collected by Network from existing databases, support National Microbiology Laboratory, Public Health Agency...
This study evaluates whether a stool donor program to supply fecal microbiota transplantation (FMT) product is feasible in the Australian regulatory environment. The primary outcome was capacity FMT product. secondary outcomes were eligibility, retention, and output.Prospective observational cohort using data collected from production records BiomeBank, South Australia. Participants people who engaged with BiomeBank's screening manufacturing process between 01 January 2021 31 December...
Tenofovir alafenamide (TAF) achieves increased renal safety and improved alanine aminotransferase (ALT) normalization but lipid profile in hepatitis B virus (HBV)-monoinfected patients switched from tenofovir disoproxil fumarate (TDF). It is unclear whether HIV coinfection perturbs these biochemical changes. To this end, we assessed parameters HIV/HBV-coinfected TDF to TAF.Retrospective, multicenter, observational study.HIV/HBV-coinfected TAF-based antiretroviral therapy (ART) at 6 Canadian...
Abstract Due to shared modes of exposure, HIV‐HBV co‐infection is common worldwide. Increased knowledge the demographic and clinical characteristics co‐infected population will allow us optimize our approach management both infections in practice. The Canadian Hepatitis B Network Cohort was utilized conduct a cross‐sectional evaluation demographic, biochemical, fibrotic treatment patients comparator HBV group. From total 5996 HBV‐infected patients, 335 were identified. characterized by older...
Pegylated interferon (Peg-IFN) is recommended as first-line therapy for chronic hepatitis B (CHB) but has significant side effects and rarely used compared to oral nucleos(t)ide analogues (NA). There are limited recent clinical efficacy or economic analysis data comparing approved CHB in North America.
Background and AimsThe obesity epidemic has increased the risk of nonalcoholic fatty liver disease (NAFLD) in both general chronic hepatitis B (CHB) populations. Our study aims to determine prevalence NAFLD patients with CHB based on controlled attenuation parameter (CAP) epidemiological, clinical, virological factors associated severe hepatic steatosis.MethodsThe Canadian Hepatitis Network cohort was utilized provide a cross-sectional description demographics, comorbidities, antiviral...
Hepatitis B virus (HBV) nucleos(t)ide analog (NA) therapy reduces liver disease but requires prolonged to achieve hepatitis surface antigen (HBsAg) loss. There is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine (LAM) tenofovir disoproxil fumarate (TDF).To assess impact of on virological response regression stiffness measurement (LSM) (i.e., FibroScan®).Retrospective, observational cohort study from...
Background: Hepatitis B surface antigen (HBsAg) loss is associated with improved clinical outcomes for individuals chronic hepatitis (CHB); however, the effects of varying HBsAg levels on in diverse cohorts are understudied. Methods: In this cross-sectional, multicentre, retrospective study, data adult subjects enrolled Canadian HBV Network CHB seen from 1 January 2012 to 30 2021 treatment and virologic within year testing were analyzed. Patients tested using qualitative (for HBsAg-negative...
Abstract Background The Hepatitis B virus (HBV) affects over 250 million people worldwide and can lead to cirrhosis hepatocellular carcinoma. HBV surface antigen (HBsAg) quantification is increasingly used predict disease activity treatment response. As there no virologic cure, clinicians are seeking a “functional cure”, or HBsAg loss, as guide safely stopping nucleos(t)ide analogue therapy. Tenofovir Disoproxil Fumarate (TDF) Entecavir (ETV) first line therapy but require prolonged achieve...