A5082468551- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Neuroblastoma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Cancer, Hypoxia, and Metabolism
- Childhood Cancer Survivors' Quality of Life
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Prenatal Screening and Diagnostics
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Gestational Trophoblastic Disease Studies
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Genomic variations and chromosomal abnormalities
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Moscow City Oncology Hospital №62
2016
Institute of Medical Cell Technologies
2007-2015
Regional Children's Hospital No1
2014
Regional Children's Clinical Hospital No. 1
2007-2014
Thomas Keating Ltd
2007
The aim of this study was to present the diagnostic and outcome characteristics infants with germline status KMT2A gene (KMT2A-g) B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treated consistently according MLL-Baby protocol, a moderate-intensity protocol. Of 139 patients enrolled in study, 100 (71.9%) carried different types rearranged (KMT2A-r), while remaining 39 (28.1%) had KMT2A-g. KMT2A-g were generally older (77% than 6 months), less likely have very high white blood cell...
Abstract Background Detection of bone marrow (BM) involvement in patients with neuroblastoma is crucial for staging and defining prognosis. Furthermore, the persistence residual tumor cells BM associated an unfavorable outcome. Methods Expression PHOX2B , TH ELAVL4 B4GALNT1 (GD2‐synthase) was analyzed by quantitative polymerase chain reaction cell lines, control samples, samples from patients. The threshold level expression each gene established through receiver operator characteristic...
Summary The prognostic value of minimal residual disease (MRD) measured by fusion‐gene transcript (FGT) detection was investigated in 76 infants (aged ≤1 year) with acute lymphoblastic leukaemia (ALL) lysine methyltransferase 2A ( KMT2A ) rearrangements. Either at the end induction or later time‐points, FGT‐MRD‐positivity associated poor outcome. after first consolidation high‐risk block detected 46·5% extremely outcome [disease‐free survival (SE) 0·06 (0·06), cumulative incidence relapse...
Summary This study aimed to evaluate the concordance between minimal residual disease (MRD) results obtained by multicolour flow cytometry (MFC) and polymerase chain reaction for fusion gene transcripts (FGTs) in infants with acute lymphoblastic leukaemia (ALL) associated rearrangement of KMT2A ( ‐r). A total 942 bone marrow (BM) samples from 123 were studied MFC‐MRD FGT‐MRD. In total, 383 (40.7%) concordantly MRD‐negative. MRD was detected two methods 441 cases (46.8%); 99 (10.5%) only...
191 consecutive unselected children with acute lymphoblastic leukemia aged from 1 to 16 years were enrolled in the study. Bone marrow samples obtained at time of initial diagnostics as well days 15 (n = 188), 36 191), and 85 187) remission induction. Minimal residual disease (MRD) was assessed by 6–10-color flow cytometry. Flow cytometry data day allowed distinguishing three patients groups significantly different outcome (p ˂ 0.0001): 35.64 % MRD < 0.1 represented 5-year event-free...
The aim of the study was to evaluate incidence and prognostic impact central nervous system (CNS) involvement in infants with B-cell precursor acute lymphoblastic leukemia (BCP-ALL), as well its relation minimal residual disease (MRD) data.A total 139 consecutive BCP-ALL from MLL-Baby trial were studied. Cerebrospinal fluid (CSF) samples investigated by microscopy cytospin slides. MRD evaluated according protocol schedule flow cytometry PCR for fusion gene transcripts (FGT).Involvement CNS...
The purpose of this work was evaluation prognostic significance 11q23/KMT2A rearrangements in infants (aged under 365 days) with B-cell precursor acute lymphoblastic leukemia (ALL) enrolled Russian-Belarus multicenter trial MLLBaby. This study is supported by the Independent Ethics Committee and approved Academic Council Research Institute Medical Cell Technologies (Ekaterinburg). Various were revealed 100 (72%) 139 patients. Event-free survival (EFS) intermediate risk group MLL-Baby 35.1%...
BACKGROUND: Molecular and clinical diversity of neuroblastomas is notorious. The activating TERT rearrangements have been associated with dismal prognosis. Suppression miR-128-3p may complement enhance the adverse effects overexpression. OBJECTIVE: study aimed at evaluation prognostic significance miR-128-3p/TERT expression in patients primary neuroblastoma. METHODS: RNA samples isolated from fresh-frozen tumor specimens (n= 103) were reverse transcribed for by qPCR. normalized levels tested...
We assessed the prognostic significance of IKZF1 gene deletions in 141 pediatric patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) on Russian multicenter trial clinics Ekaterinburg and Orenburg. were estimated by multiplex ligation-dependent probe amplification. revealed 15 (10.6 %) patients. associated age older than 10 years (p = 0.007), initial white blood cell count higher 30 × 109/l 0.003), t(9;22)(q34.q11) 0.003) delayed blast clearance: М3 status bone marrow at...